Multi-Tiered Systems of Support (MTSS) is a framework that can be used for a range of intervention service delivery models, including those that seek to remediate maladaptive learning, behavioral, or social-emotional deficits before they lead to disability placement, office discipline referrals, significant social-emotional concerns, or self-harm/suicide. The three-tiered MTSS framework offers more intensive interventions and more frequent progress monitoring at each tier. Using MTSS for academics, behavior, social-emotional wellbeing, and suicide prevention promotes uniformity across schools, provides early intervention to students, abides by state guidelines, and recognizes that academic, behavioral, and social-emotional difficulties tend to be interconnected and often do not operate independently of one another. This quick-reference guide presents detailed MTSS flowcharts for academic RTI, behavior (school wide positive behavioral support/SWPBS), social emotional RTI, and suicide prevention. Each flowchart: identifies core curriculum, practices, and programs; suggests universal screening tools; lists criteria for determining whether to advance student to next tier; recommends interventions at each tier; identifies progress monitoring tools and frequency of use. Guidance counselors, teachers, and administrators will find this concise yet comprehensive guide to be an essential tool for supporting students across domains in an organized and coherent fashion.