Laser Ablation Ambient Ionization Mass Spectrometry And Micro X Ray Fluorescence Imaging As Orthogonal Techniques For The Analysis Of Pharmaceuticals
Download Laser Ablation Ambient Ionization Mass Spectrometry And Micro X Ray Fluorescence Imaging As Orthogonal Techniques For The Analysis Of Pharmaceuticals full books in PDF, epub, and Kindle. Read online free Laser Ablation Ambient Ionization Mass Spectrometry And Micro X Ray Fluorescence Imaging As Orthogonal Techniques For The Analysis Of Pharmaceuticals ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author | : Tim Elseberg |
Publisher | : |
Total Pages | : |
Release | : 2017 |
Genre | : |
ISBN | : |
Download Laser Ablation-ambient Ionization-mass Spectrometry and Micro X-ray Fluorescence Imaging as Orthogonal Techniques for the Analysis of Pharmaceuticals Book in PDF, Epub and Kindle
Author | : Kei Zaitsu |
Publisher | : Elsevier |
Total Pages | : 292 |
Release | : 2019-11-06 |
Genre | : Science |
ISBN | : 0128172215 |
Download Ambient Ionization Mass Spectrometry in Life Sciences Book in PDF, Epub and Kindle
Ambient Ionization Mass Spectrometry in Life Sciences: Principles and Applications is a systematic introduction to this rapidly expanding area of study. Underlying principles of each technique are explained in detail, along with discussions on their applications across life science disciplines. Ambient ionization has recently emerged as one of the hottest and fastest growing topics in mass spectrometry, hence this book is not just for analysts and researchers who use and study mass spectrometry. This volume would be of interest to anyone who works in or studies analytical chemistry, omics sciences (including metabolomics), pharmacokinetics, forensic science or drug analysis. Covers the most up-to-date techniques, including DART, DCBI, DESI, PESI, PSI, REIMS and laser-based ambient ionization Includes easy-to-understand pros and cons of each ionization technique to aid in decision-making Provides plentiful examples of life science applications
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2001 |
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Download Laser Ablation Electrospray Ionization for Ambient Analysis and Molecular Imaging with Mass Spectrometry Book in PDF, Epub and Kindle
Laser ablation electrospray ionization for ambient analysis and molecular imaging with mass spectrometry.
Author | : David M. Lubman |
Publisher | : Oxford University Press, USA |
Total Pages | : 560 |
Release | : 1990 |
Genre | : Science |
ISBN | : 0195059298 |
Download Lasers and Mass Spectrometry Book in PDF, Epub and Kindle
Contributors to this volume focus on the fundamentals of the technique of analyzing material based on the atomic weight of the species, using the power and definition of lasers to enable measurement of smaller quantities and more finely localized particles. Each chapter deals with a particular application area and should be sufficient to form an entry point for the utilization of mass spectrometry by graduate students and researchers. The book provides the first full discussion of the new techniques of laser applications in the field.
Author | : Rainer Cramer |
Publisher | : Springer |
Total Pages | : 287 |
Release | : 2015-11-09 |
Genre | : Science |
ISBN | : 3319048198 |
Download Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry Book in PDF, Epub and Kindle
This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: • Showcases new techniques and applications in MALDI MS • Demonstrates how MALDI is preferable to ESI (electrospray ionization) • Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics
Author | : |
Publisher | : |
Total Pages | : 164 |
Release | : 2019 |
Genre | : |
ISBN | : 9789463439220 |
Download Ambient Laser Ablation Electrospray Ionization Mass Spectrometry Imaging Book in PDF, Epub and Kindle
Identification and confirmation of (bio)chemical entities in ambient MS mostly involves accurate mass determination, often in combination with MS/MS work flows. However, an accurate mass only provides the elemental composition of the (bio)molecule, still resulting in numerous possible structures. MS/MS procedures are often insufficient in differentiating between the hundreds possible candidate substances in database searches. Obtaining additional information and thereby improving structural assignment as well as reducing the vast number of possible candidates is thus of high importance in any ambient MS(I) study. In Chapter 5 we present an ambient hydrogen/deuterium exchange (HDX) LAESI-MS method for structure elucidation and confirmation of (bio)molecules. The concept was demonstrated with small molecules, peptides, and proteins. Moreover, the same approach could be applied to MSI as shown by the ambient MSI of arginine and oligosaccharides on an orange slice. Eventually, this approach will allow spatially resolved MSI of different protein conformers and may have a major impact in the life sciences.
Author | : Laura M Cole |
Publisher | : Springer Nature |
Total Pages | : 217 |
Release | : 2023-07-06 |
Genre | : Science |
ISBN | : 1071633198 |
Download Imaging Mass Spectrometry Book in PDF, Epub and Kindle
This second edition details new and updated chapters on key methodologies and breakthroughs in the mass spectrometry imaging (MSI) field. Chapters guide readers through nano-Desorption Electrospray Ionisation (nDESI), Matrix Assisted Laser Desorption Ionisation-2 (MALDI-2), Laser Ablation - Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) ,Imaging Mass Cytometry (IMC) with a variety of diverse samples including eye tissue, crop analysis, 3D cell culture models, and counterfeit goods analysis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Imaging Mass Spectrometry: Methods and Protocols, Second Edition aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Author | : Ralf Zimmermann |
Publisher | : John Wiley & Sons |
Total Pages | : 448 |
Release | : 2021-07-06 |
Genre | : Science |
ISBN | : 3527335102 |
Download Photoionization and Photo-Induced Processes in Mass Spectrometry Book in PDF, Epub and Kindle
Provides comprehensive coverage of laser-induced ionization processes for mass spectrometry analysis Drawing on the expertise of the leading academic and industrial research groups involved in the development of photoionization methods for mass spectrometry, this reference for analytical scientists covers both the theory and current applications of photo-induced ionization processes. It places widely used techniques such as MALDI side by side with more specialist approaches such as REMPI and RIMS, and discusses leading edge developments in ultrashort laser pulse desorption, to give readers a complete picture of the state of the technology. Photoionization and Photo-Induced Processes in Mass Spectrometry: Fundamentals and Applications starts with a complete overview of the fundamentals of the technique, covering the basics of the gas phase ionization as well as those of laser desorption and ablation, pulse photoionization, and single particle ionization. Numerous application examples from different analytical fields are described that showcase the power and the wide scope of photo ionization in mass spectrometry. -The first general reference book on photoionization techniques for mass spectrometry -Examines technologies and applications of gas phase resonance-enhanced multiphoton ionization mass spectrometry (REMPI-MS) and gas phase resonance ionization mass spectrometry (RIMS) -Provides complete coverage of popular techniques like MALDI -Discusses the current and potential applications of each technology, focusing on process and environmental analysis Photoionization and Photo-Induced Processes in Mass Spectrometry: Fundamentals and Applications is an excellent book for spectroscopists, analytical chemists, photochemists, physical chemists, and laser specialists.
Author | : Leonard Nyadong |
Publisher | : |
Total Pages | : |
Release | : 2009 |
Genre | : Chemistry, Forensic |
ISBN | : |
Download Ambient Ionization Mass Spectrometry for the Forensic Screening of Pharmaceuticals and the Determination of Potential Drug Candidates Book in PDF, Epub and Kindle
Ambient mass spectrometry (MS) is a new and growing sub-field in MS which has opened new research avenues, particularly for applications relating to the analysis of solid samples. Results on the implementation and application of ambient MS techniques including: desorption electrospray ionization (DESI) and direct analysis in real time (DART) indicated that these techniques could serve as complementary tools for the rapid qualitative screening of pharmaceuticals, allowing up to two orders of magnitude improvement in throughput compared to traditional methods such as liquid chromatography MS. The selectivity of DESI could be enhanced by performing the experiment in the reactive mode. In this mode, complexation reactions between reagents added to the spray solvent and analytes on the sample surface resulted in analyte stabilization, inhibiting fragmentation. They also resulted in a concomitant enhancement in the analyte surface activity, facilitating their evaporation from secondary droplets culminating in an improvement in sensitivity. Also for drug tablets analysis, the analyte signal dependency on DESI geometrical set-up variables could be mitigated following the careful and controlled addition of an isotopically labeled internal standard (IS) to the sample or by spraying samples with a pair of reagents with different affinities for the analyte. Either of these approaches resulted in an analyte-to-IS signal ratio (in the former) or an analyte complex ratio (in the later), which was largely independent of DESI experimental variables allowing quantitative analysis using this technique. DESI MS was also observed to be a very powerful tool for determining the 2-D distribution of various pharmaceutically important compounds on tablet and tissue surfaces. The ability to map the distribution of molecules of interest by DESI MS has very great implications in drug tablet quality control and in determining the role of chemical signals presented on tissue surfaces. DESI was observed to be limited to ionizing molecules of medium to high polarities without much limitation in terms of mass range, whereas DART was better suited for the analysis of molecules within a broader range of polarities, but within a more limited mass range (up to 800 Da approximately). These limitations were circumvented by implementing a novel multimode ambient ion source, desorption electrospray/metastable-induced ionization (DEMI), which combines various aspects of DESI and DART. Initial experiments with the DEMI ion source demonstrated its ability to enable the simultaneous analysis of molecules within a broader range of polarities and masses than DESI and DART alone.
Author | : Alison E Ashcroft |
Publisher | : Royal Society of Chemistry |
Total Pages | : 188 |
Release | : 2007-10-31 |
Genre | : Science |
ISBN | : 184755119X |
Download Ionization Methods in Organic Mass Spectrometry Book in PDF, Epub and Kindle
Ionization Methods in Organic Mass Spectrometry is a basic practical guide for scientists of all disciplines who wish to analyse samples by organic mass spectrometry. Concentrating on instrumental operation, this book gives step-by-step instructions on how to set up, and how to achieve the best results, using a range of ionization methods, including atmospheric pressure chemical ionization, electrospray ionization and matrix assisted laser desorption ionization. Ionization Methods in Organic Mass Spectrometry will enable a beginner, or practitioner with limited experience, to choose the most appropriate ionization technique in application areas such as biomolecules, drugs and metabolites, pesticides, polymers and many other organic compounds. It will be a valuable practical guide for technicians, graduates, students or researchers - or indeed anyone new to practical organic mass spectrometry.