Kinetics Of Enzyme Action
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Author | : Ross L. Stein |
Publisher | : John Wiley & Sons |
Total Pages | : 322 |
Release | : 2011-08-08 |
Genre | : Science |
ISBN | : 1118084403 |
Download Kinetics of Enzyme Action Book in PDF, Epub and Kindle
Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.
Author | : Ross L. Stein |
Publisher | : John Wiley & Sons |
Total Pages | : 322 |
Release | : 2011-08-23 |
Genre | : Science |
ISBN | : 0470414111 |
Download Kinetics of Enzyme Action Book in PDF, Epub and Kindle
Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.
Author | : Keith James Laidler |
Publisher | : Oxford : Clarendon Press |
Total Pages | : 482 |
Release | : 1973 |
Genre | : Science |
ISBN | : |
Download The Chemical Kinetics of Enzyme Action Book in PDF, Epub and Kindle
Author | : Daniel L. Purich |
Publisher | : Elsevier |
Total Pages | : 915 |
Release | : 2010-06-16 |
Genre | : Science |
ISBN | : 0123809258 |
Download Enzyme Kinetics: Catalysis and Control Book in PDF, Epub and Kindle
Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions
Author | : Antonio Baici |
Publisher | : Springer |
Total Pages | : 503 |
Release | : 2015-06-24 |
Genre | : Science |
ISBN | : 3709114020 |
Download Kinetics of Enzyme-Modifier Interactions Book in PDF, Epub and Kindle
The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.
Author | : Athel Cornish-Bowden |
Publisher | : Elsevier |
Total Pages | : 221 |
Release | : 2014-05-20 |
Genre | : Science |
ISBN | : 1483164675 |
Download Principles of Enzyme Kinetics Book in PDF, Epub and Kindle
Principles of Enzyme Kinetics discusses the principles of enzyme kinetics at an intermediate level. It is primarily written for first-year research students in enzyme kinetics. The book is composed of 10 chapters. Chapter 1 provides the basic principles of enzyme kinetics with a brief discussion of dimensional analysis. Subsequent chapters cover topics on the essential characteristics of steady-state kinetics, temperature dependence, methods for deriving steady-state rate equations, and control of enzyme activity. Integrated rate equations, and introductions to the study of fast reactions and the statistical aspects of enzyme kinetics are provided as well. Chemists and biochemists will find the book invaluable.
Author | : Hans Bisswanger |
Publisher | : John Wiley & Sons |
Total Pages | : 340 |
Release | : 2017-06-22 |
Genre | : Science |
ISBN | : 3527806474 |
Download Enzyme Kinetics Book in PDF, Epub and Kindle
Now in full color for a more intuitive learning experience, this new edition of the long-selling reference also features a number of new developments in methodology and the application of enzyme kinetics. Starting with a description of ligand binding equilibria, the experienced author goes on to discuss simple and complex enzyme reactions in kinetic terms. Special cases such as membrane-bound and immobilized enzymes are considered, as is the influence of external conditions, such as temperature and pH value. The final part of the book then covers a range of widely used measurement methods and compares their performance and scope of application. With its unique mix of theory and practical advice, this is an invaluable aid for teaching as well as for experimental work.
Author | : Raymond Chang |
Publisher | : University Science Books |
Total Pages | : 706 |
Release | : 2005-02-11 |
Genre | : Science |
ISBN | : 9781891389337 |
Download Physical Chemistry for the Biosciences Book in PDF, Epub and Kindle
This book is ideal for use in a one-semester introductory course in physical chemistry for students of life sciences. The author's aim is to emphasize the understanding of physical concepts rather than focus on precise mathematical development or on actual experimental details. Subsequently, only basic skills of differential and integral calculus are required for understanding the equations. The end-of-chapter problems have both physiochemical and biological applications.
Author | : Irwin H. Segel |
Publisher | : |
Total Pages | : 957 |
Release | : 2014 |
Genre | : Enzyme kinetics |
ISBN | : 9788126548156 |
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Author | : Swati Nagar |
Publisher | : Humana |
Total Pages | : 0 |
Release | : 2014-02-13 |
Genre | : Medical |
ISBN | : 9781627037570 |
Download Enzyme Kinetics in Drug Metabolism Book in PDF, Epub and Kindle
Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.