Intrinsic mutagenesis

Intrinsic mutagenesis
Author: Burnet MacFarlane
Publisher: Springer Science & Business Media
Total Pages: 245
Release: 2012-12-06
Genre: Medical
ISBN: 9401166064

Download Intrinsic mutagenesis Book in PDF, Epub and Kindle

This book is something which almost accidentally has developed very differently from how it was initially planned. The intention was to elaborate the part played by the immune system in ageing with the role of the thymus as central theme. It was to be essentially an expansion of a lecture I gave in 1970 and would inevitably have been concerned with much the same material as Walford's book, The Immunologic Theory of Aging, though from a different slant. What changed its character arose from a series of attempts to find logical connection between two findings that most gerontologists regard as axiomatic: that the lifespan of a mammal is genetically determined, and that the actual process of ageing is an accumulation of genetic error, of somatic mutations. It is possible that the connection is so indirect, circuitous and multiform that generations of detailed and unattractive research will be needed to elucidate it, or, more likely, the whole matter discarded as a non-problem. But a more inspiring approach does seem possible. The working hypothesis, which halfway through its writing became the new central theme of the book, arose when I was a member of a committee appointed by the Australian Academy of Science at the request of the Australian Government to advise on the danger from French nuclear tests in the South Pacific.

Intrinsic Mutagenesis

Intrinsic Mutagenesis
Author: Frank M. Burnet
Publisher:
Total Pages: 253
Release: 1974
Genre:
ISBN: 9780783734347

Download Intrinsic Mutagenesis Book in PDF, Epub and Kindle

Comparative Vs Ontogenetic Paradigms for Tests of the Intrinsic Mutagenesis Hypothesis of Aging

Comparative Vs Ontogenetic Paradigms for Tests of the Intrinsic Mutagenesis Hypothesis of Aging
Author:
Publisher:
Total Pages:
Release: 1979
Genre:
ISBN:

Download Comparative Vs Ontogenetic Paradigms for Tests of the Intrinsic Mutagenesis Hypothesis of Aging Book in PDF, Epub and Kindle

This paper examines certain aspects of the biology of longevity and aging that bear on the role of DNA in the ontogenetic aging process, and on the genetic basis for the differences of longevity among mammal species. (PCS).

Conditional Mutagenesis: An Approach to Disease Models

Conditional Mutagenesis: An Approach to Disease Models
Author: Robert Feil
Publisher: Springer Science & Business Media
Total Pages: 528
Release: 2007-02-01
Genre: Medical
ISBN: 3540351094

Download Conditional Mutagenesis: An Approach to Disease Models Book in PDF, Epub and Kindle

In this book, leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse and their application to model human physiology and pathophysiology. The book illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. In addition, it considers the development of new drugs to treat human diseases.

Mutagenesis

Mutagenesis
Author: Rajnikant Mishra
Publisher: BoD – Books on Demand
Total Pages: 260
Release: 2012-08-17
Genre: Science
ISBN: 9535107070

Download Mutagenesis Book in PDF, Epub and Kindle

The complexity of problem understanding biochemical and molecular basis of healthy life, and eagerness to find simple solution necessitate evolution of technology like mutagenesis. The chapters of this book contain experiences of scientists working in the area of mutagenesis. It describes suitable experimental models (microorganism, plants or animals) for testing spontaneous and induced mutations which are useful for basic and translational research. It includes methods towards gene targeting, developing disease and pest resistant plants, creating temperature sensitive molecular machines, understanding mitochondrial mutagenesis, detecting anti-mutagens, improving genetic insight into impaired immunity and disease. It also describes mutagenesis induced by DNA damage. It has also provided advantage of in vitro transcription and translation to yield proteins with point mutations, deletions or insertions for studying stability, DNA-protein or protein-protein interaction. Trust, it will serve readers as valuable integrated resources emphasizing methods of mutagenesis, and understanding mechanism of variable penetrance or expressivity of mutations.

Advances in Mutagenesis Research 2

Advances in Mutagenesis Research 2
Author: Günter Obe
Publisher: Springer Science & Business Media
Total Pages: 333
Release: 2012-12-06
Genre: Science
ISBN: 3642755992

Download Advances in Mutagenesis Research 2 Book in PDF, Epub and Kindle

The new field of applied genetic research, genetic toxicology and mutation research investigates the muta- genicity and cancerogenicity of chemicals and other agents. Permanent changes in genes and chromosomes, or genome mutations, can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Mutagenesis research has two aims: (1) to understand the molecular mechanisms leading to mutations, and (2) to prevent a thoughtless introduction of mutagenic agents into our environment. Both aspects, namely, basic and applied, will be treated in the new series Advances in Mutagenesis Research.

Advances in Mutagenesis Research

Advances in Mutagenesis Research
Author: Günter Obe
Publisher: Springer Science & Business Media
Total Pages: 225
Release: 2012-12-06
Genre: Science
ISBN: 3642749550

Download Advances in Mutagenesis Research Book in PDF, Epub and Kindle

The new field of applied genetic research, genetic toxicology and mutation research investigates the mutagenicity and cancerogenicity of chemicals and other agents. Permanent changes in genes and chromosomes, or genome mutations, can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Mutagenesis research has two aims: (1) to understand the molecular mechanisms leading to mutations, and (2) to prevent a thoughtless introduction of mutagenic agents into our environment. Both aspects, namely, basic and applied, will be treated in the new series Advances in Mutagenesis Research.

In Vitro Mutagenesis Protocols

In Vitro Mutagenesis Protocols
Author: Jeff Braman
Publisher: Springer Science & Business Media
Total Pages: 284
Release: 2008-02-05
Genre: Science
ISBN: 1592591949

Download In Vitro Mutagenesis Protocols Book in PDF, Epub and Kindle

Hands-on researchers with proven track records describe in stepwise fashion their advanced mutagenesis techniques. The contributors focus on improvements to conventional site-directed mutagenesis, including a chapter on chemical site-directed mutagenesis, PCR-based mutagenesis and the modifications that allow high throughput mutagenesis experiments, and mutagenesis based on gene disruption (both in vitro- and in situ-based). Additional methods are provided for in vitro gene evolution; for gene disruption based on recombination, transposon, and casette mutagenesis; and for facilitating the introduction of multiple mutations. Time-tested and highly practical, the protocols in In Vitro Mutagenesis Protocols, 2nd Edition offer today's molecular biologists reliable and powerful techniques with which to illuminate the proteome.

Molecular and Cellular Mechanisms of Mutagenesis

Molecular and Cellular Mechanisms of Mutagenesis
Author: J. Lemontt
Publisher: Springer Science & Business Media
Total Pages: 391
Release: 2012-12-06
Genre: Science
ISBN: 1461334764

Download Molecular and Cellular Mechanisms of Mutagenesis Book in PDF, Epub and Kindle

It has been nearly 35 years since the peacetime Biology Division of Oak Ridge National Laboratory was started, born of rather inauspicious conditions. Virtually no facilities were available and most of the wartime scientists had left. So, when we started out, it was obvious to me that something had to be done to reestab lish research. Even more, because Oak Ridge was not known at that time for its biological work but rather for the separation of Uranium 235, nuclear reactor development, and radioisotope produc tion, a new tradition had to be promoted. Although good biological work had been done at Oak Ridge during the war to protect the workers and the results of this work were quite excellent, very few installations remained. When we started the work of the Biology Division, it became essential to make it part of the flow of mod~rn biology allover the world. As Director, I had to do more than just attract promising scientists. We created an atmosphere conducive to creative research and nurtured all of the other aspects of a productive laboratory. Of course, we carefully prepared the results of our work in publish able form. We made a sincere effort to invite seminar speakers and lecturers to come to Oak Ridge despite the sacrifices this presented to our early budget. We also had to do something more, and here I "cashed in" on my experience of the previous 15 years.

Mutagenicity: Assays and Applications

Mutagenicity: Assays and Applications
Author: Ashutosh Kumar
Publisher: Academic Press
Total Pages: 352
Release: 2017-09-26
Genre: Science
ISBN: 0128092602

Download Mutagenicity: Assays and Applications Book in PDF, Epub and Kindle

Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials