The pandemic has deepened existing trends in the international system, in particular the readjustment of alliances between nations and between regions. As spheres of influence disintegrate and reform, so national and regional security policies will change in unforeseen ways notwithstanding that individual state self-preservation will dominate policy choice. Three major dimensions are addressed. The first dimension is International Relations and Economy. The coronavirus has accelerated a global economic crisis comparable to those of 1929, 1987 and 2008. Are the major economic trading blocs moving to a war economy, and who might win or lose in this context? The second dimension of analysis is the growth of Information Communication. Hybrid and fragmented, especially in terms of the use of social media, the use of veiled threat and promoting discord in the form of providing provocative information on topics of the day can lead to conflict consequences and all its negative impacts. The third dimension is Geopolitical Reconfiguration. While world powers are always manoeuvring for an enhanced military and economic position, the pandemic offers new opportunities to capitalise on the changing power balance. The editors and contributors engage with the differing power polarities between China, the United States, India, Brazil, Russia, and the European Union. This book is one of the first to present research on the effects of COVID-19 on national public policy. Cross-cultural analysis of its effects, and the way in which different societies have addressed the fight against the virus, provides insight into the relations between states and possible solutions in the international arena. The work is essential reading for all those involved in international affairs and policy-making.