Influenza: A Century of Research

Influenza: A Century of Research
Author: Irina Kiseleva
Publisher: Bentham Science Publishers
Total Pages: 214
Release: 2021-07-07
Genre: Science
ISBN: 1681088452

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Influenza is one of the most ancient and intriguing diseases that has been accompanying our civilization for millennia. While mankind has successfully defeated many dangerous influenza infections in the last couple of centuries, influenza control remains a serious problem for public health. A number of influenza vaccines and antiviral compounds have been licensed in recent times. However, the influenza virus is still ahead of us, as it continues to persistently infect humans to this day. Influenza: A Century of Research shows how influenza virology has developed historically and the tremendous knowledge that has been uncovered in the study of influenza. In this monograph, the authors present a historical perspective on influenza, chronologically, with an emphasis on its virology. Chapters cover information about the isolation of the first influenza viruses, substrates, and models for studying influenza, structure, and life cycle of the influenza virus, mechanisms of attenuation and virulence. Chapters progress into the multidisciplinary aspects of influenza research such as influenza virus ecology and the evolutionary origin of epidemic and pandemic influenza viruses. A significant part of the book also covers the description of the prevention and treatment of influenza and reasons that have contributed to insufficient control for influenza. The questions of how the COVID-19 pandemic affects the circulation of seasonal respiratory viruses, and if we can eliminate this virus are also addressed. Influenza: A Century of Research is an informative source of information for a broad range of readers, academic or otherwise, who are interested in knowing more about the disease.

Influenza

Influenza
Author: Irina Kiseleva; Natalie
Publisher:
Total Pages: 210
Release: 2021-07-07
Genre:
ISBN: 9781681088464

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Influenza is one of the most ancient and intriguing diseases that has been accompanying our civilization for millennia. While mankind has successfully defeated many dangerous influenza infections in the last couple of centuries, influenza control remains a serious problem for public health. A number of influenza vaccines and antiviral compounds have been licensed in recent times. However, the influenza virus is still ahead of us, as it continues to persistently infect humans to this day. Influenza: A Century of Research shows how influenza virology has developed historically and the tremendous knowledge that has been uncovered in the study of influenza. In this monograph, the authors present a historical perspective on influenza, chronologically, with an emphasis on its virology. Chapters cover information about the isolation of the first influenza viruses, substrates, and models for studying influenza, structure, and life cycle of the influenza virus, mechanisms of attenuation and virulence. Chapters progress into the multidisciplinary aspects of influenza research such as influenza virus ecology and the evolutionary origin of epidemic and pandemic influenza viruses. A significant part of the book also covers the description of the prevention and treatment of influenza and reasons that have contributed to insufficient control for influenza. The questions of how the COVID-19 pandemic affects the circulation of seasonal respiratory viruses, and if we can eliminate this virus are also addressed. Influenza: A Century of Research is an informative source of information for a broad range of readers, academic or otherwise, who are interested in knowing more about the disease.

Influenza

Influenza
Author: George J. Dehner
Publisher: University of Pittsburgh Pre
Total Pages: 296
Release: 2012-04-15
Genre: Medical
ISBN: 0822977850

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In 1976, the outbreak of a new strain of swine flu at the Fort Dix, New Jersey, army base prompted an unprecedented inoculation campaign. Some forty-two million Americans were vaccinated as the National Influenza Immunization Program hastened to prevent a pandemic, while the World Health Organization (WHO) took a wait-and-see approach. Fortunately, the virus did not spread, and only one death occurred. But instead of being lauded, American actions were subsequently denounced as a "fiasco" and instigator of mass panic. In Influenza, George Dehner examines the wide disparity in national and international responses to influenza pandemics, from the Russian flu of 1889 to the swine flu outbreak in 2009. He chronicles the technological and institutional progress made along the way and shows how these developments can shape an effective future policy. Early pandemic response relied on methods of quarantine and individual scientific research. In the aftermath of World War II, a consensus for cooperation and shared resources led to the creation of the WHO, under the auspices of the United Nations. Today, the WHO maintains a large and proactive role in responding to influenza outbreaks. International pandemic response, however, is only as strong as its weakest national link—most recently evidenced in the failed early detection of the 2009 swine flu in Mexico and the delayed reporting of the 2002 SARS outbreak in China. As Dehner's study contends, the hard lessons of the past highlight the need for a coordinated early warning system with full disclosure, shared technologies, and robust manufacturing capabilities. Until the "national" aspect can be removed from the international equation, responses will be hampered, and a threat to an individual remains a threat to all.

The Threat of Pandemic Influenza

The Threat of Pandemic Influenza
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 431
Release: 2005-04-09
Genre: Medical
ISBN: 0309095042

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Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.

The Great Influenza

The Great Influenza
Author: John M. Barry
Publisher: Penguin
Total Pages: 580
Release: 2005-10-04
Genre: History
ISBN: 9780143036494

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#1 New York Times bestseller “Barry will teach you almost everything you need to know about one of the deadliest outbreaks in human history.”—Bill Gates "Monumental... an authoritative and disturbing morality tale."—Chicago Tribune The strongest weapon against pandemic is the truth. Read why in the definitive account of the 1918 Flu Epidemic. Magisterial in its breadth of perspective and depth of research, The Great Influenza provides us with a precise and sobering model as we confront the epidemics looming on our own horizon. As Barry concludes, "The final lesson of 1918, a simple one yet one most difficult to execute, is that...those in authority must retain the public's trust. The way to do that is to distort nothing, to put the best face on nothing, to try to manipulate no one. Lincoln said that first, and best. A leader must make whatever horror exists concrete. Only then will people be able to break it apart." At the height of World War I, history’s most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease.

Flu

Flu
Author: Gina Kolata
Publisher: Farrar, Straus and Giroux
Total Pages: 378
Release: 2011-04-01
Genre: Social Science
ISBN: 1429979356

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Veteran journalist Gina Kolata's Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It presents a fascinating look at true story of the world's deadliest disease. In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out. Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

Exploring Lessons Learned from a Century of Outbreaks

Exploring Lessons Learned from a Century of Outbreaks
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 231
Release: 2019-06-05
Genre: Medical
ISBN: 0309490359

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In November 2018, an ad hoc planning committee at the National Academies of Sciences, Engineering, and Medicine planned two sister workshops held in Washington, DC, to examine the lessons from influenza pandemics and other major outbreaks, understand the extent to which the lessons have been learned, and discuss how they could be applied further to ensure that countries are sufficiently ready for future pandemics. This publication summarizes the presentations and discussions from both workshops.

Influenza

Influenza
Author: Jeremy Brown
Publisher: Atria Books
Total Pages: 272
Release: 2019-10-01
Genre: Social Science
ISBN: 1501181254

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“Highlights that influenza is still a real and present threat and demonstrates the power and limitations of modern medicine.” —The Wall Street Journal “A surprisingly compelling and accessible story of one of the world’s most deadly diseases. It is timely and interesting, engaging and sobering.” —David Gregort, CNN political analyst and former moderator for NBC’s Meet the Press A veteran ER doctor explores the troubling, terrifying, and complex history and present-day research of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure? While influenza is now often thought of as a common but mild disease, it still kills more than thirty thousand people in the United States each year. Dr. Jeremy Brown, a veteran ER doctor and director of the Office of Emergency Care Research at the National Institutes of Health, talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a road map to protect us from the next outbreak. Dr. Brown explores the terrifying and complex history of the flu virus and looks at the controversy over vaccinations and the federal government’s role in preparing for pandemic outbreaks. Though a hundred years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts.

Influenza

Influenza
Author: Jeremy Brown
Publisher: Thorndike Press Large Print
Total Pages: 0
Release: 2019-08-21
Genre: Medical
ISBN: 9781432865009

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On the 100th anniversary of the pandemic of 1918, Jeremy Brown, veteran ER doctor and Director of Emergency Care Research at the National Institutes of Health, explores the troubling and complex history of the flu virus. He breaks down the current dialogue about the disease, explaining the controversy over vaccinations, antiviral drugs, and the federal government's role in preparing for pandemic outbreaks. Influenza is an enlightening and unnerving look at a deadly virus that has been around longer than people and may be for many more years before we are able to conquer it for good.

Global Flu and You

Global Flu and You
Author: George Dehner
Publisher: Reaktion Books
Total Pages: 194
Release: 2013-02-15
Genre: Science
ISBN: 1780230575

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Winter brings snow, ice, and freezing temperatures, but these climatic conditions are also the harbingers of another time of year: flu season. We all know the signs—chills, fever, sore throat, muscle pains, coughing—and hope that this common illness will make us sick for only a few days. But though the flu may seem harmless, influenza results in between 250,000 and 500,000 deaths every year and can spread virulently around the world. In pandemic years, the flu can kill millions. The recurrence of the Spanish Flu virus, the appearance and spread of Bird Flu, and the 2009 Swine Flu have heightened concerns about the dangers posed by flu pandemics. Drawing on his extensive research into influenza pandemics, George Dehner refutes the idea that these are a new phenomenon. In Global Flu and You, he traces the origins of the disease and outlines the societal and cultural changes that enabled the virus to become an epidemic threat. He reveals that while medical and scientific breakthroughs in studying and protecting against the virus have made rapid progress, demographic, economic, and technical changes have served to speed up and amplify the potential impacts of an influenza pandemic. Accessibly written for any reader, Global Flu and You exposes the facts and fictions of an illness we could all succumb to and is a must-read for anyone concerned with their own—and the world’s—health.