The Molecular Mechanisms of Chronic Inflammation Development

The Molecular Mechanisms of Chronic Inflammation Development
Author: Masaaki Murakami
Publisher: Frontiers E-books
Total Pages: 121
Release:
Genre:
ISBN: 2889190919

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Inflammation is critical for the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, cancers, and cardiovascular diseases. Inflammation comes as two types: chronic inflammation, which can be defined as a dysregulated form of inflammation, and acute inflammation, which can defined as a regulated form. Because of its special role in the aforementioned diseases, establishing methods to control chronic inflammation is important for developing cures and treatments. One challenge for this purpose has been the ability to distinguish chronic and acute inflammation based on molecular biology diagnostics. Thus, this Research Topic is focused on articles that can shed some new light on the molecular mechanisms responsible for the development of chronic inflammation and its related conditions.

Translational Inflammation

Translational Inflammation
Author:
Publisher: Academic Press
Total Pages: 294
Release: 2018-11-24
Genre: Medical
ISBN: 0128138335

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Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application

Translational Immunology

Translational Immunology
Author: Seng-Lai Tan
Publisher: Academic Press
Total Pages: 386
Release: 2015-11-18
Genre: Medical
ISBN: 0128017570

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Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings. Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field. Delivers comprehensive coverage of seminal human immunology discoveries and the resulting impact on therapeutic strategies Presents potential novel targets and approaches for clinical applications in organ specific and systemic autoimmunity, transplant rejection, cancer, and vaccine development Discusses lessons learned from successful and failed clinical trials with specific interventions, including pharmacological issues and limitations, and complications due to immunosuppression Provides information on new strategies and outstanding issues that should be addressed in future research

Inflammatory Processes:

Inflammatory Processes:
Author: L. Gordon Letts
Publisher: Springer
Total Pages: 146
Release: 2012-12-06
Genre: Medical
ISBN: 3034884680

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In November 1998 many of the key leaders of new drug discovery for inflammatory diseases gathered at Hershey, Pennsylvania for the 9th International Conference of the Inflammation Research Association. The Conference was held over a five day period and provided a stimulating environment for the open exchange of important advances in basic inflammation research as well as new drug discovery and development. This book encompasses some of the highlights of several presentations made at the Conference. It contains some of the latest and important developments in the field of inflammation research. Topics include the status of eotaxin and chemokines in asthma and allergy, signal transduction and regulation of diverse mediators such as the JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well as regulators of AP-1, macrophage metalloproteinases, lymphotoxin and further insights into the role of MCP-1 in disease. Also discussed are drug targets in rheumatoid and osteoarthritis, fibrotic diseases,...

Cell Migration in Inflammation and Immunity

Cell Migration in Inflammation and Immunity
Author: Daniele D'Ambrosio
Publisher:
Total Pages:
Release: 2003
Genre:
ISBN:

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Cell migration is now well recognized as a critical component of the inflammatory disease process, so that its proper understanding promises to generate both ground-breaking basic discoveries and the development of novel therapeutics. In Cell Migration in Inflammation and Immunity: Methods and Protocols, leading cell biologists and immunologists present their most widely useful and innovative techniques for studying the molecular and cellular basis of this phenomenon. Describing each method in step-by-step detail, the authors provide a series of focused, cutting-edge techniques proceeding from the in vitro analysis of cell migration and the molecular mechanisms underlying this process, to methodologies for the analysis of cell migration in vivo. Methods for the analysis of rapid leukocyte adhesion under flow conditions in vitro are described, which may prove especially fruitful for scientists exploring the molecular mechanisms underlying both vascular recognition and leukocyte-endothelium interaction. Experimental approaches useful in establishing the role of cell migration in the pathogenesis of both acute and chronic inflammatory diseases are emphasized. Each fully tested protocol includes an introduction explaining the principle behind the technique, equipment and reagent lists, and tips on troubleshooting and how to avoid known pitfalls. Comprehensive and cutting-edge, Cell Migration in Inflammation and Immunity: Methods and Protocols offers novice and experienced investigators alike a collection of powerful techniques for studying the molecular basis and pathophysiological significance of cell migration in inflammatory and immune diseases, as well as for the development of novel therapeutics.

Translational Studies on Inflammation

Translational Studies on Inflammation
Author: Ane C.F. Nunes
Publisher: BoD – Books on Demand
Total Pages: 249
Release: 2020-01-08
Genre: Medical
ISBN: 178984357X

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Inflammation is known worldwide, from the bench to the bedside, but it is a hard theme to approach with one single point of view.In this sense, a selection of translational studies would support the medical-scientific community to better understand the complex network of the inflammatory process, its maintenance, and potential treatment targets. The eleven chapters that compose this book present interesting insights into inflammation and its mechanisms, merging classic background with innovative approaches. From the molecular basis to experimental models, the chapters selected for this book bring to readers at different academic levels updated and practical data on inflammation. Find out what drives interdisciplinary medical research on inflammation and enjoy this informative collection.

Cellular and Molecular Aspects of Inflammation

Cellular and Molecular Aspects of Inflammation
Author: George Poste
Publisher: Springer
Total Pages: 496
Release: 2012-03-26
Genre: Medical
ISBN: 9781468454895

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The characterization of the cellular and molecular mechanisms that mediate inflammation provides a foundation that supports future studies that will de fine mechanisms more intimately. It encourages substantial optimism about the opportunities to understand the inflammatory process and to use that information to develop novel therapeutic approaches. Recent progress has defined the cells that mediate the inflammatory response, many of the inter cellular transmitters, the receptors, signal transduction processes and regula tory mechanisms. Thus, we now have the opportunity to understand inflammation in pharmacologic terms and to attack the key molecular targets to develop new therapeutics. Among the cells involved in the inflammatory response are the lympho cytes, neutrophils and endothelial cells. Maintenance of homeostasis, re sponse to proinflammatory stimuli and pathophysiologic responses are products of complex interactions between these and other elements of the immune systems. Each of these cells displays a variety of receptors to define the stimuli to which they respond. The receptors displayed that the signal transduction processes and cellular responses are regulated genetically and epigenetic ally . The critical role of membranes and particularly the phospho lipid components of the membranes is emphasized by recent studies.