Stress-Induced Mutagenesis

Stress-Induced Mutagenesis
Author: David Mittelman
Publisher: Springer Science & Business Media
Total Pages: 284
Release: 2013-03-12
Genre: Medical
ISBN: 1461462800

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The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.

Induced Mutagenesis

Induced Mutagenesis
Author: Christopher W. Lawrence
Publisher: Springer Science & Business Media
Total Pages: 433
Release: 2013-03-09
Genre: Medical
ISBN: 1468443828

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Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.

Somaclonal Variation and Induced Mutations in Crop Improvement

Somaclonal Variation and Induced Mutations in Crop Improvement
Author: S.M. Jain
Publisher: Springer Science & Business Media
Total Pages: 615
Release: 2013-03-14
Genre: Science
ISBN: 9401591253

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Genetic variability is an important parameter for plant breeders in any con ventional crop improvement programme. Very often the desired variation is un available in the right combination, or simply does not exist at all. However, plant breeders have successfully recombined the desired genes from cultivated crop gerrnplasm and related wild species by sexual hybridization, and have been able to develop new cultivars with desirable agronomie traits, such as high yield, disease, pest, and drought resistance. So far, conventional breeding methods have managed to feed the world's ever-growing population. Continued population growth, no further scope of expanding arable land, soil degradation, environ mental pollution and global warrning are causes of concern to plant biologists and planners. Plant breeders are under continuous pressure to improve and develop new cultivars for sustainable food production. However, it takes several years to develop a new cultivar. Therefore, they have to look for new technologies, which could be combined with conventional methods to create more genetic variability, and reduce the time in developing new cultivars, with early-maturity, and improved yield. The first report on induced mutation of a gene by HJ. Muller in 1927 was a major mi1estone in enhancing variation, and also indicated the potential applica tions of mutagenesis in plant improvement. Radiation sources, such as X-rays, gamma rays and fast neutrons, and chemical mutagens (e. g. , ethyl methane sulphonate) have been widely used to induce mutations.

Plant Mutagenesis and Crop Improvement

Plant Mutagenesis and Crop Improvement
Author: Nitish Kumar
Publisher: CRC Press
Total Pages: 302
Release: 2024-02-23
Genre: Science
ISBN: 1003834248

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Crop improvement using classically induced mutagenesis is now well standardized. Many new promising varieties of different crops have been successfully developed worldwide using both physical and chemical mutagens. Voluminous literature is now available on basic and applied aspects of mutagenesis. The mutation technique has been refined and holds the promise of generating much wider and more desirable variability than classical breeding. Recent advances in technology combined with classical mutation breeding offer new and exciting challenges for the development of new varieties. A global inventory of induced mutagenesis activities for crop improvement is requried. This book covers both basic and applied aspects of mutation and its impact on various crops: it is extremely well prepared and contains a huge volume of information accumulated using classically induced mutagenesis on different crops in different countries. Three key features: Describes the importance of induced mutation in crop plant research and its application to production Highlights new advances in the understanding of plant mutagenesis in crop improvement Contains contributions from major leaders in the field of plant mutation research This volume brings together all the important and relevant literature in the field. It provides a complete account of the mutation breeding of crops, presenting conclusions about the value of the method, its possibilities, limitations, and shortcomings, and the possible difficulties of further application in various crops. The initial chapters deal with the interactions between mutagenic treatment and plant material, such as aspects of mutagenic treatment, postirradiation behavior of shoot apices, and adventitious bud techniques. All available literature is then discussed crop by crop and critically evaluated. This will serve as an extremely comprehensive guide for researchers, teachers, students, and individuals who are interested in using induced mutagenesis as a tool for crop improvement.

C. Elegans II

C. Elegans II
Author: Donald L. Riddle
Publisher: Firefly Books
Total Pages: 1252
Release: 1997
Genre: Medical
ISBN: 9780879695323

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Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR

Induced Mutagenesis

Induced Mutagenesis
Author: Christopher W. Lawrence
Publisher: Springer
Total Pages: 0
Release: 1983-01-01
Genre: Medical
ISBN: 9780306411632

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Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.

Mutagenesis

Mutagenesis
Author: N. B. Tomlekova
Publisher: Brill Wageningen Academic
Total Pages: 0
Release: 2014
Genre: Biodiversity
ISBN: 9789086862443

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In the present era various international organizations, such as FAO, UNO, IAEA, FNCA, etc., have unanimously agreed that millions of people in both developing and developed countries are not only facing a shortage of food, but also non-availability of nutrients. The main reason put forward by these agencies is that there is less genetic diversity prevalent in the major crops, which has been further diminished since the inception of conventional plant breeding. Since the first decade of the last century the mutation breeding approach has been pivotal in enhancing the genetic diversity of crops, thereby enriching the genetic pool. `Mutagenesis: exploring genetic diversity of crops¿ describes the latest achievements in mutation breeding, with a particular focus on the development of novel mutant varieties and F1 hybrids of crops highly superior to the parental ones. The book details experimental as well as literary studies of induced mutagenesis and its role in developing the new potent varieties. The book will be useful for agricultural policy making authorities in countries of agricultural importance, scientific researchers, breeders, teachers and students keen to use mutation breeding and to explore its hidden potential to secure food and nutrient availability for the growing world population.

Chemically-Induced DNA Damage, Mutagenesis, and Cancer

Chemically-Induced DNA Damage, Mutagenesis, and Cancer
Author: Ashis K. Basu
Publisher: MDPI
Total Pages: 275
Release: 2018-08-27
Genre: Science
ISBN: 3038971294

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This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS

Biotechnologies for Plant Mutation Breeding

Biotechnologies for Plant Mutation Breeding
Author: Joanna Jankowicz-Cieslak
Publisher: Springer
Total Pages: 343
Release: 2016-12-08
Genre: Science
ISBN: 3319450212

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This book is open access under a CC BY-NC 2.5 license. This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.

Plant Mutation Breeding and Biotechnology

Plant Mutation Breeding and Biotechnology
Author: Q. Y. Shu
Publisher: CABI
Total Pages: 612
Release: 2012
Genre: Nature
ISBN: 1780640854

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Abstract: This book presents contemporary information on mutagenesis in plants and its applications in plant breeding and research. The topics are classified into sections focusing on the concepts, historical development and genetic basis of plant mutation breeding (chapters 1-6); mutagens and induced mutagenesis (chapters 7-13); mutation induction and mutant development (chapters 14-23); mutation breeding (chapters 24-34); or mutations in functional genomics (chapters 35-41). This book is an essential reference for those who are conducting research on mutagenesis as an approach to improving or modifying a trait, or achieving basic understanding of a pathway for a trait --.