Carbon Black, Titanium Dioxide, and Talc

Carbon Black, Titanium Dioxide, and Talc
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher:
Total Pages: 468
Release: 2010
Genre: Air
ISBN:

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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Author: The International Agency for Research on Cancer
Publisher:
Total Pages: 0
Release: 2011-02-07
Genre: Medical
ISBN: 9789283212935

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This volume of the IARC Monographs provides a reassessment of the carcinogenicity of carbon black, titanium dioxide, and talc. All of these agents are poorly soluble particles that are weakly toxic, and were chosen for assessment because evidence suggests that they cause cancer in the respiratory tract of rats through mechanisms similar to those that are operative in people who work in dusty environments (eg. coal mines). An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard of these particles upon inhalation by humans.

Some Drugs and Herbal Products

Some Drugs and Herbal Products
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: World Health Organization
Total Pages: 440
Release: 2016
Genre: Health & Fitness
ISBN: 9789283201465

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This volume of the IARC Monographs provides an assessment of the carcinogenicity of 14 drugs and herbal products. The IARC Monographs Working Group relied mainly on epidemiological studies to evaluate the carcinogenic hazard to humans exposed to the drugs digoxin (widely prescribed for the treatment of chronic heart failure), pioglitazone (used for the treatment of type 2 diabetes mellitus), and hydrochlorothiazide (used to treat hypertension). Other agents evaluated included the drugs primidone, sulfasalazine, pentosan polysulfate sodium, and triamterene, and five herbal products (or their components): Aloe vera whole leaf extract, goldenseal root powder, Ginkgo biloba leaf extract, kava extract, and pulegone. In view of the limited agent-specific information available from epidemiological studies, assessments of these agents relied mainly on carcinogenicity bioassays to reach conclusions as to the carcinogenic hazard to exposed humans.

Some Industrial Chemicals

Some Industrial Chemicals
Author: International Agency for Research on Cancer
Publisher: International Agency for Research on Cancer
Total Pages: 0
Release: 2018-07-27
Genre: Medical
ISBN: 9789283201533

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This volume of the IARC Monographs provides evaluations of the carcinogenicity of: N,N-dimethylformamide, a solvent produced in high volumes and commonly used in many industrial processes; 2-mercaptobenzothiazole, a rubber accelerant and preservative; the rocket fuel hydrazine; the widely used fire retardant tetrabromobisphenol A; 1-bromopropane, a solvent used in dry cleaning, degreasing and adhesive resins; the seed fumigant 3-chloro-2-methylpropene; and N,N-dimethyl-p-toluidine, a hardening agent in dental and bone adhesives. Exposure to all seven agents considered may occur in the general population as well as in different occupational settings. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of environmental or occupational exposure to these agents.