In a knowledge-based economy, universities are vital institutions. This volume explores the roles that universities can play in peripheral regions, contributing to processes of regional economic development and innovative growth. Including a series of case studies drawn from Portugal, Norway, Finland, the Czech Republic, Estonia and the Dutch-German border region, this will be the first book to offer a comprehensive comparative overview of universities in European economically peripheral regions. These studies seek to explore the tensions that arise in peripheral regions where there may not be obvious matches between university activities and regional strengths. Aimed at academics, policy-makers and practitioners working on regional innovation strategies, this volume brings a much-needed sense of realism and ambition for all those concerned with building successful regional societies at the periphery of the knowledge economy.