Although first reported in 1973, immune heparin-induced thrombocytopenia (HIT) remains one of the most potentially devastating and frequent adverse drug reactions encountered by physicians. This Fourth Edition reinforces its standing as the leading guide to the accurate diagnosis and management of HIT by identifying key signs and symptoms of this disorder and providing clear intervention strategies, including detailed information on the use of alternative anticoagulants to manage these critical circumstances. Intended for those requiring an expert source of guidance for the quick detection and control of HIT, this reference: contains new chapters on novel pharmacotherapies, recent drug approvals, current dosing guidelines, and the advantages and limitations of alternative anticoagulants reviews the immune basis and pathogenesis, clinical features, differential diagnosis, and laboratory testing for HIT antibodies, and provides evidence-based guidelines for the recognition, treatment, and prevention of this disorder details actions that should and should not be taken after the identification of HIT helps physicians select from a variety of new treatment options, and determines which of these agents are safe and effective for their patients provides a comprehensive overview of clinical and laboratory studies on HIT summarizes various myths and treatment paradoxes