This handbook is an essential resource which brings into focus key advances, challenges and lessons learned in strengthening human resources for health (HRH) data and evidence as a strategic objective of implementing the Global Strategy on Human Resources for Health: Workforce 2030, the recommendations of the United Nations Secretary-General High-level Commission on Health Employment and Economic Growth, and in the achievement of the WHO Thirteenth General Programme of Work (2019–2023 (GPW 13) targets, for a measurable impact on population health and development. Divided into three parts, the handbook presents the complementarity between WHO Health Labour Market Analysis Guidebook and WHO handbook on national health workforce accounts (NHWA) system strengthening approach to improving the availability, quality, analysis, dissemination and use of health workforce data and evidence to inform decision-making and planning in countries. It also features the committed country efforts, catalysed by networks and partner investments, in strengthening HRH information systems and their growing success in implementing NHWA and other WHO normative tools. Contributed by the six technical working groups of the Global Health Workforce Network (GHWN) Data and Evidence hub, the handbook is aimed at HRH policy-makers and planners, to provide contemporary insight on data sources and information needs to address policy questions around health workforce development, and as part of the broader intersectoral agenda to strengthening health systems resilience.