Handbook of Systems Biology

Handbook of Systems Biology
Author: Marian Walhout
Publisher: Academic Press
Total Pages: 553
Release: 2012-12-31
Genre: Science
ISBN: 012385945X
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This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines Includes the latest research developments in human and animal models to assist with translational research Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Handbook of Computational Molecular Biology

Handbook of Computational Molecular Biology
Author: Srinivas Aluru
Publisher: CRC Press
Total Pages: 1108
Release: 2005-12-21
Genre: Computers
ISBN: 1420036270
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The enormous complexity of biological systems at the molecular level must be answered with powerful computational methods. Computational biology is a young field, but has seen rapid growth and advancement over the past few decades. Surveying the progress made in this multidisciplinary field, the Handbook of Computational Molecular Biology of

Handbook of Statistical Systems Biology

Handbook of Statistical Systems Biology
Author: Michael Stumpf
Publisher: John Wiley & Sons
Total Pages: 624
Release: 2011-09-09
Genre: Science
ISBN: 1119952042
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Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.

Handbook of Research on Systems Biology Applications in Medicine

Handbook of Research on Systems Biology Applications in Medicine
Author: Daskalaki, Andriani
Publisher: IGI Global
Total Pages: 982
Release: 2008-11-30
Genre: Technology & Engineering
ISBN: 1605660779
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"This book highlights the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatics, molecular, and biochemical, to address fundamental questions in complex diseases like cancer diabetes but also in ageing"--Provided by publisher.

Compact Handbook of Computational Biology

Compact Handbook of Computational Biology
Author: A.K. Konopka
Publisher: CRC Press
Total Pages: 572
Release: 2004-08-30
Genre: Mathematics
ISBN: 020302141X
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The assimilation of computational methods into the life sciences has played an important role in advancing biological research. From sequencing genomes to discovering motifs in large collections of functionally equivalent sequences of nucleic acids and proteins, the value of powerful computational tools has become abundantly clear. The Compact Hand

Handbook of Research on Computational and Systems Biology

Handbook of Research on Computational and Systems Biology
Author: Limin Angela Liu
Publisher: IGI Global
Total Pages: 0
Release: 2011
Genre: Computers
ISBN: 9781609604912
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"This book offers information on the state-of-the-art development in the fields of computational biology and systems biology, presenting methods, tools, and applications of these fields by many leading experts around the globe"--Provided by publisher.

Handbook of the Biology of Aging

Handbook of the Biology of Aging
Author: Nicolas Musi
Publisher: Academic Press
Total Pages: 576
Release: 2015-08-20
Genre: Medical
ISBN: 0124116205
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Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Cancer Systems Biology

Cancer Systems Biology
Author: Edwin Wang
Publisher: CRC Press
Total Pages: 456
Release: 2010-05-04
Genre: Computers
ISBN: 9781439811863
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The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation methods to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorigenesis, cancer researchers can uncover a series of new discov

Handbook of Systems Biology

Handbook of Systems Biology
Author: Alexis White
Publisher:
Total Pages: 207
Release: 2019-06-20
Genre:
ISBN: 9781641161435
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Systems biology is an interdisciplinary field of science that is concerned with the computational and mathematical modeling of biological systems which are complex in nature. The field strives to model and discover properties of cells, tissues and organisms functioning as a system. These involve metabolic networks and cell signaling networks. Some associated disciplines of system biology are phenomics, genomics, epigenetics, proteomics, biomics, etc. Systems biology is an upcoming field of science that has undergone rapid development over the past few decades. This book covers in detail some existing theories and innovative concepts revolving around systems biology. It consists of contributions made by international experts. It is a vital tool for all researching and studying this field.

Systematic

Systematic
Author: James R. Valcourt
Publisher: Bloomsbury Publishing USA
Total Pages: 289
Release: 2017-02-07
Genre: Science
ISBN: 1632860317
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A brilliant young scientist introduces us to the fascinating field that is changing our understanding of how the body works and the way we can approach healing. SYSTEMATIC is the first book to introduce general readers to systems biology, which is improving medical treatments and our understanding of living things. In traditional bottom-up biology, a biologist might spend years studying how a single protein works, but systems biology studies how networks of those proteins work together--how they promote health and how to remedy the situation when the system isn't functioning properly. Breakthroughs in systems biology became possible only when powerful computer technology enabled researchers to process massive amounts of data to study complete systems, and has led to progress in the study of gene regulation and inheritance, cancer drugs personalized to an individual's genetically unique tumor, insights into how the brain works, and the discovery that the bacteria and other microbes that live in the gut may drive malnutrition and obesity. Systems biology is allowing us to understand more complex phenomena than ever before. In accessible prose, SYSTEMATIC sheds light not only on how systems within the body work, but also on how research is yielding new kinds of remedies that enhance and harness the body's own defenses.