Guide To Cytochromes
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Author | : David F. V. Lewis |
Publisher | : CRC Press |
Total Pages | : 252 |
Release | : 2001-08-23 |
Genre | : Medical |
ISBN | : 9780748408979 |
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Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate level or in particular within the pharmaceutical industry. A Guide to Cytochrome P450 Structure and Function acts as an adjunct to the previous book Cytochromes P450: Structure, Function and Mechanism. It reviews the current status of the P450 field in terms of our present knowledge and understanding of the enzymes structure and function, including their multiplicity of forms, diversity of substrates, and selectivity. This is brought together with the latest research topics, including pharmacogenetics, regulation, human DMEs, toxicity screening and molecule modeling, to provide a fast-track approach for those new to the field.
Author | : David F. V. Lewis |
Publisher | : CRC Press |
Total Pages | : 223 |
Release | : 2001-04-12 |
Genre | : Medical |
ISBN | : 1420023047 |
Download Guide to Cytochromes P450 Book in PDF, Epub and Kindle
Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate level or in particular within the pharmaceutical industry. A Guide to Cytochrome P450 Structure and Function acts as an adjunct to the previous book Cytochromes P450: Structure, Function and Mechanism. It reviews the current status of the P450 field in terms of our present knowledge and understanding of the enzymes structure and function, including their multiplicity of forms, diversity of substrates, and selectivity. This is brought together with the latest research topics, including pharmacogenetics, regulation, human DMEs, toxicity screening and molecule modeling, to provide a fast-track approach for those new to the field.
Author | : David F.V. Lewis |
Publisher | : Taylor & Francis |
Total Pages | : 344 |
Release | : 2003-09 |
Genre | : Science |
ISBN | : 1135743282 |
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Author | : D. F. V. Lewis |
Publisher | : |
Total Pages | : 0 |
Release | : 2001 |
Genre | : Cytochrome P-450 |
ISBN | : |
Download Guide to Cytochrome P450 Structure and Function Book in PDF, Epub and Kindle
Reviews the current status of the P450 field in terms of our present knowledge and understanding of the enzymes structure and function along with the latest research topics to provide a fast-track approach for those new to the field.
Author | : D. F. V. Lewis |
Publisher | : |
Total Pages | : 215 |
Release | : 2001 |
Genre | : MEDICAL |
ISBN | : 9780367800956 |
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Author | : Eugene G. Hrycay |
Publisher | : Springer |
Total Pages | : 376 |
Release | : 2015-05-22 |
Genre | : Medical |
ISBN | : 3319160095 |
Download Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 Book in PDF, Epub and Kindle
This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.
Author | : Robert C. Smart |
Publisher | : John Wiley & Sons |
Total Pages | : 1060 |
Release | : 2017-11-03 |
Genre | : Science |
ISBN | : 1119042429 |
Download Molecular and Biochemical Toxicology Book in PDF, Epub and Kindle
Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition
Author | : Johannes Kirchmair |
Publisher | : John Wiley & Sons |
Total Pages | : 538 |
Release | : 2014-06-26 |
Genre | : Medical |
ISBN | : 3527673016 |
Download Drug Metabolism Prediction Book in PDF, Epub and Kindle
The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists. The authors provide more than a systematic overview of computational tools and knowledge bases for drug metabolism research and their underlying principles. They aim to convey their expert knowledge distilled from many years of experience in the field. In addition to the fundamentals, computational approaches and their applications, this volume provides expert accounts of the latest experimental methods for investigating drug metabolism in four dedicated chapters. The authors discuss the most important caveats and common errors to consider when working with experimental data. Collating the knowledge gained over the past decade, this practice-oriented guide presents methods not only used in drug development, but also in the development and toxicological assessment of cosmetics, functional foods, agrochemicals, and additives for consumer goods, making it an invaluable reference in a variety of disciplines.
Author | : |
Publisher | : Academic Press |
Total Pages | : 506 |
Release | : 2015-07-23 |
Genre | : Medical |
ISBN | : 0128031204 |
Download Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer Book in PDF, Epub and Kindle
Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer, the latest volume in the Advances in Pharmacology series, presents not only the function of cytochrome P450 but also its pharmacological roles in inflammation and cancer. Contains contributions from the best authors in the field Ideal reference for those conducting research in cancer, inflammation, cytochrome P450, metabolism, liver disease, and oxidative stress Provides an essential resource for pharmacologists, immunologists, and biochemists
Author | : Martin M. Zdanowicz |
Publisher | : ASHP |
Total Pages | : 425 |
Release | : 2010 |
Genre | : Medical |
ISBN | : 1585282340 |
Download Concepts in Pharmacogenomics Book in PDF, Epub and Kindle
The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time.If you are pharmacist, resident, or student curious about this new field, start withConcepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application and implementation.Features include: case studies in each chapter clinical pearls illustrations of key concepts figures, diagrams, and flow charts for visual learners key points summarized.