Principles of Translational Science in Medicine

Principles of Translational Science in Medicine
Author: Martin Wehling
Publisher: Academic Press
Total Pages: 365
Release: 2015-04-02
Genre: Science
ISBN: 0128007214
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Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Follow the Money: Funding Research in a Large Academic Health Center

Follow the Money: Funding Research in a Large Academic Health Center
Author: Henry R. Bourne
Publisher: Lulu.com
Total Pages: 233
Release: 2016
Genre: Business & Economics
ISBN: 0996324216
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Threatened by sharp cuts in state government support and stagnant federal research funding, US public research universities are becoming fragile ecosystems. By charting flows of research dollars through a leading public research university-the University of California, San Francisco (UCSF)-this book illuminates how such schools work to cope with these funding threats and how the challenges and coping strategies affect organization and direction of research. Academic leaders, faculty, administrators, and students will learn how a complex academic health center manages its revenues, expenses, and diverse academic cultures. For the first time, they can begin to understand arcane mysteries of indirect cost recovery, sponsored funds, capital investment, endowments, debt, and researchers' salaries.

From Bench to BedsideTrauma, Tumors, Spine, Functional Neurosurgery

From Bench to BedsideTrauma, Tumors, Spine, Functional Neurosurgery
Author: Francesco Signorelli
Publisher: BoD – Books on Demand
Total Pages: 170
Release: 2016-09-28
Genre: Medical
ISBN: 9535126288
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This book is written for graduate students, researchers, and practitioners who are interested in learning how the knowledge from research can be implemented in clinical competences. The first section is dedicated to deep brain stimulation, a surgical procedure which is the paramount example of how clinical practice can take advantage from fundamental research. The second section gathers four chapters on four different topics and illustrates how significant is the challenge to translate scientific advances into clinical practice because the route from evidence to action is not always obvious. It is hoped that this book will stimulate the interest in the process of translating research into practice for a broader range of neurosurgical topics than the one covered by this book, which could result in a forthcoming more comprehensive publication.

Sustainability in high performance sport

Sustainability in high performance sport
Author: Natalie Barker-Ruchti
Publisher: Routledge
Total Pages: 133
Release: 2017-10-02
Genre: Education
ISBN: 1317327926
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Success in high performance sport is highly valued in today’s world, with lucrative contracts, sponsorship deals, and opportunities for celebrity status balanced against substantial investments of time and energy, and high chances of failure. With pressure mounting on athletes and coaches to make the most of athletic investments, the temptation to make health-related or ethical compromises is growing. Sustainability in High Performance Sport examines the pressures faced by coaches and athletes, and considers how sustainable science can offer alternative pathways to sporting excellence. By applying principles relating to carrying capacities, complexity and uncertainty, production and consumption, and ethics, this unique book provides new ways of thinking about both enduring and emerging challenges. With a scope that includes themes such as coaching practices, coach-athlete relationships, over-training and injuries, the development of sporting expertise, and doping, Sustainability in High Performance Sport is the most comprehensive exploration of sustainability in elite sport available. It is an invaluable resource for anybody with an interest in achieving long-term success in high performance sport. This book was originally published as a special issue of Reflective Practice.

Bioethics, Genetics and Sport

Bioethics, Genetics and Sport
Author: Silvia Camporesi
Publisher: Routledge
Total Pages: 366
Release: 2018-04-09
Genre: Medical
ISBN: 1317485386
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Advances in genetics and related biotechnologies are having a profound effect on sport, raising important ethical questions about the limits and possibilities of the human body. Drawing on real case studies and grounded in rigorous scientific evidence, this book offers an ethical critique of current practices and explores the intersection of genetics, ethics and sport. Written by two of the world's leading authorities on the ethics of biotechnology in sport, the book addresses the philosophical implications of the latest scientific developments and technological data. Distinguishing fact from popular myth and science fiction, it covers key topics such as the genetic basis of sport performance and the role of genetic testing in talent identification and development. Its ten chapters discuss current debates surrounding issues such as the shifting relationship between genetics, sports medicine and sports science, gene enhancement, gene transfer technology, doping and disability sport. The first book to be published on this important subject in more than a decade, this is fascinating reading for anyone with an interest in the ethics of sport, bioethics or sport performance.

Bone Cancer

Bone Cancer
Author: Dominique Heymann
Publisher: Academic Press
Total Pages: 1080
Release: 2021-09-23
Genre: Medical
ISBN: 0323899900
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Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease. Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

Tangled Diagnoses

Tangled Diagnoses
Author: Ilana Löwy
Publisher: University of Chicago Press
Total Pages: 326
Release: 2018-04-19
Genre: History
ISBN: 022653426X
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Since the late nineteenth century, medicine has sought to foster the birth of healthy children by attending to the bodies of pregnant women, through what we have come to call prenatal care. Women, and not their unborn children, were the initial focus of that medical attention, but prenatal diagnosis in its present form, which couples scrutiny of the fetus with the option to terminate pregnancy, came into being in the early 1970s. Tangled Diagnoses examines the multiple consequences of the widespread diffusion of this medical innovation. Prenatal testing, Ilana Löwy argues, has become mainly a risk-management technology—the goal of which is to prevent inborn impairments, ideally through the development of efficient therapies but in practice mainly through the prevention of the birth of children with such impairments. Using scholarship, interviews, and direct observation in France and Brazil of two groups of professionals who play an especially important role in the production of knowledge about fetal development—fetopathologists and clinical geneticists—to expose the real-life dilemmas prenatal testing creates, this book will be of interest to anyone concerned with the sociopolitical conditions of biomedical innovation, the politics of women’s bodies, disability, and the ethics of modern medicine.

Imperfect Pregnancies

Imperfect Pregnancies
Author: Ilana Löwy
Publisher: JHU Press
Total Pages: 295
Release: 2017-12
Genre: Health & Fitness
ISBN: 1421423634
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Introduction : scrutinized fetuses -- Born imperfect : birth defects before prenatal diagnosis -- Karyotypes -- Human malformations -- From prenatal diagnosis to prenatal screening -- Sex chromosome aneuploidies -- PND and new genomics approaches -- Conclusion : PND's slippery slopes, imagined and real

Routledge Handbook of Genomics, Health and Society

Routledge Handbook of Genomics, Health and Society
Author: Sahra Gibbon
Publisher: Routledge
Total Pages: 474
Release: 2018-04-17
Genre: Science
ISBN: 1315451670
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The Handbook provides an essential resource at the interface of Genomics, Health and Society, and forms a crucial research tool for both new students and established scholars across biomedicine and social sciences. Building from and extending the first Routledge Handbook of Genetics and Society, the book offers a comprehensive introduction to pivotal themes within the field, an overview of the current state of the art knowledge on genomics, science and society, and an outline of emerging areas of research. Key themes addressed include the way genomic based DNA technologies have become incorporated into diverse arenas of clinical practice and research whilst also extending beyond the clinic; the role of genomics in contemporary ‘bioeconomies’; how challenges in the governance of medical genomics can both reconfigure and stabilise regulatory processes and jurisdictional boundaries; how questions of diversity and justice are situated across different national and transnational terrains of genomic research; and how genomics informs – and is shaped by – developments in fields such as epigenetics, synthetic biology, stem cell, microbial and animal model research. Chapters 13 and 28 of this book are freely available as downloadable Open Access PDFs at http://www.taylorfrancis.com, under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.