Free Radicals and Iron

Free Radicals and Iron
Author: Martyn C. R. Symons
Publisher:
Total Pages: 262
Release: 1998
Genre: Active oxygen in the body
ISBN:
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This concise monograph describes a variety of important reactions of iron in biological free-radical reactions. It presents both a chemical and a biochemical perspective of the topic, but at the same time unifies ideas where possible. Iron plays a key role in biological life processes, as acatalayst enabling us to use oxygen to generate the heat and chemical energy that drives life. When iron is not properly controlled within the body it can cause damage by making free radicals. The authors present a chemical and biomedical perspective of how reactions of iron complexes and freeradicals may contribute to human health and disease, especially in reactions of oxygen and hydrogen peroxide.

Techniques in Free Radical Research

Techniques in Free Radical Research
Author: A.T. Diplock
Publisher: Elsevier
Total Pages: 309
Release: 1991-12-11
Genre: Science
ISBN: 0080858910
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Free radical species are generally short-lived due to their high reactivity and thus direct measurement and identification are often impossible. ESR is the only technique which has the potential for direct detection of radicals but in biological systems even these must be trapped by a spin-trapping agent. Thus most investigations involve recognition of indicators of the presence of radicals in vivo or "FOOTPRINTS" of radical-mediated damage. Techniques in Free Radical Research assembles and critically assesses the most relevant and reliable experimental approaches used towards the measurement of radicals and radical-mediated damage in chemical systems, in cells and in tissues under the following six headings: a) Footprints of DNA damage, b) Footprints of protein damage, c) Footprints of lipid peroxidation, d) Footprints of antioxidant consumption, e) Footprints via indirect radical assays, and f) Footprints via the availability of transition metal complexes.

Iron Metabolism in Health and Disease

Iron Metabolism in Health and Disease
Author: Jeremy H. Brock
Publisher: Bailliere Tindall Limited
Total Pages: 512
Release: 1994
Genre: Medical
ISBN:
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An overview of human iron metabolism. This book reviews the metabolic importance of iron in evolution, the physiology and biochemistry of internal iron exchange, iron absorption and iron storage, the molecular regulation of cellular iron homeostasis and aspects of iron and disease.

Free Radicals, Oxidative Stress, and Antioxidants

Free Radicals, Oxidative Stress, and Antioxidants
Author: Tomris Özben
Publisher: Springer Science & Business Media
Total Pages: 416
Release: 1998-04-30
Genre: Science
ISBN: 9780306458132
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There has been an explosion of research related to free radicals and antioxidants in recent years, and hundreds of laboratories worldwide are actively involved in many as pects of free radicals, oxidative stress, and antioxidants. The literature on these topics in creases exponentially every year. Over the last few years, we have been fortunate to witness a widespread recognition of the important role of free radicals in a wide variety of pathological conditions including diseases such as atherosclerosis, cardiovascular and neurological diseases, ischemia, emphysema, diabetes, radiation injury, cancer, etc. In ad dition, many laboratories are studying the role of free radicals in the inexorable process of aging. Increased evidence involves free radicals with the etiology of various diseases, thereby suggesting the use of antioxidants as a viable therapeutic approach for the treat ment of free radical mediated pathologies. Despite these impressive developments, many important aspects of free radical and antioxidant research are open for investigation. It is important to understand the overall mechanisms involved in free radical mediated physiological and pathological conditions. This knowledge will undoubtedly lead to the development of new therapeutic approaches to prevent or control free radical related diseases. This book contains the proceedings of the NATO Advanced Study Institute (ASI) on "Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Sig nificance," which was held in Antalya, Turkey from May 24-June 4, 1997.

Free Radicals in Biology and Medicine

Free Radicals in Biology and Medicine
Author: Barry Halliwell
Publisher: Oxford University Press, USA
Total Pages: 568
Release: 1989
Genre: Biochemistry
ISBN:
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"This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet." "This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and medical sciences."--BOOK JACKET.

Oxygen Radicals in Biology and Medicine

Oxygen Radicals in Biology and Medicine
Author: Michael Simic
Publisher: Springer Science & Business Media
Total Pages: 1064
Release: 2013-03-09
Genre: Science
ISBN: 1468455680
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This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.

Free Radicals and Oxidation Phenomena in Biological Systems

Free Radicals and Oxidation Phenomena in Biological Systems
Author: Roberfroid
Publisher: CRC Press
Total Pages: 292
Release: 1994-12-14
Genre: Medical
ISBN: 9780824795870
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This work offers an analysis of the biological processes mediated by free radicals, from a toxicological point of view, providing easy access to information in an integrated, coherent presentation. The chemistry and biochemistry of all principal types of radical are explained, and the multiple forms in whch radicals participate in living organisms are investigated.;This work should be of use to biochemists, pharmacologists, pharmaceutical researchers, food scientists and technologists, nutritionists, toxicologists, chemists, biologists and graduate students in these disciplines.

Iron and Human Disease

Iron and Human Disease
Author: R.B. Lauffer
Publisher: CRC Press
Total Pages: 550
Release: 2018-01-18
Genre: Medical
ISBN: 1351082345
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Iron and Human Disease is the first book to cover the three key aspects of human iron metabolism: the accumulation of iron in adults, iron as a limiting factor for tumor and infectious cell growth, and iron as a catalyst for oxygen free radical production. The book describes the hypotheses and findings related to the role of iron in cardiovascular disease (including reperfusion injury), cancer, aging, and autoimmune and neurodegenerative diseases. Other topics covered include the molecular biology and biochemistry of iron, the general principles governing iron balance, iron in the immune system and acute phase response, and new preventive and therapeutic strategies. Iron and Human Disease will be a useful reference for biomedical investigators, physicians, nutritionists, and public health officials.

Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 798
Release: 2002-07-19
Genre: Medical
ISBN: 0309072905
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This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.