Fred Sanger - Double Nobel Laureate

Fred Sanger - Double Nobel Laureate
Author: George G. Brownlee
Publisher: Cambridge University Press
Total Pages: 315
Release: 2020-04-02
Genre: Science
ISBN: 1316124053

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Considered 'the father of genomics', Fred Sanger (1918–2013) paved the way for the modern revolution in our understanding of biology. His pioneering methods for sequencing proteins, RNA and, eventually, DNA earned him two Nobel Prizes. He remains one of only four scientists (and the only British scientist) ever to have achieved that distinction. In this, the first full biography of Fred Sanger to be published, Brownlee traces Sanger's life from his birth in rural Gloucestershire to his retirement in 1983 from the Medical Research Council's Laboratory of Molecular Biology in Cambridge. Along the way, he highlights the remarkable extent of Sanger's scientific achievements and provides a real portrait of the modest man behind them. Including an extensive transcript of a rare interview of Sanger by the author, this biography also considers the wider legacy of Sanger's work, including his impact on the Human Genome Project and beyond.

Frederick Sanger

Frederick Sanger
Author: Joe S. Jeffers
Publisher: Springer
Total Pages: 94
Release: 2017-03-14
Genre: Science
ISBN: 3319547097

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In this Brief, Joe Jeffers uncovers the life and works of two-time Nobel Laureate Frederick Sanger. Following Sanger’s early life to retirement, Jeffers describes how this celebrated British biochemist became the first person to determine the amino acid sequence of a protein for which he was awarded the Nobel Prize in 1958. Highlighting Sanger’s remarkable career, Jeffers describes Sanger’s later change in research direction to investigate deoxyribonucleic acids (DNA), work for which Sanger also received the Nobel Prize jointly with Paul Berg and Walter Gilbert in 1980. Joe Jeffers conducted twelve interviews with Sanger over the period of 1999-2009 and he has also spoken to more than 40 of Sanger’s colleagues and family members. This brief provides a rigorous yet concise view of Sanger on a personal and scientific level and is suitable for biochemists, historians or the interested layperson.

The Discovery of Insulin

The Discovery of Insulin
Author: Michael Bliss
Publisher: University of Toronto Press
Total Pages: 320
Release: 2017-06-22
Genre: Medical
ISBN: 1487516746

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The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine.

Selected Papers of Frederick Sanger

Selected Papers of Frederick Sanger
Author: Frederick Sanger
Publisher: World Scientific
Total Pages: 680
Release: 1996
Genre: Science
ISBN: 9789810224301

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This important volume is mainly concerned with the development of methods for ?sequencing? ? that is, determination of the order of the amino acids in proteins and of nucleotides in RNA and DNA. In 1943 the position of only one amino acid in a protein (insulin) was known, and Sanger's first paper resulted in finding a second amino acid. In his final paper in 1982 he describes the determination of a DNA sequence of 48,502 nucleotides. The papers describe the steady improvements in techniques, and exciting biological results revealed by the sequences.

Lives And Times Of Great Pioneers In Chemistry (Lavoisier To Sanger)

Lives And Times Of Great Pioneers In Chemistry (Lavoisier To Sanger)
Author: C N R Rao
Publisher: World Scientific
Total Pages: 323
Release: 2015-11-18
Genre: Science
ISBN: 9814689076

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Chemical science has made major advances in the last few decades and has gradually transformed in to a highly multidisciplinary subject that is exciting academically and at the same time beneficial to human kind. In this context, we owe much to the foundations laid by great pioneers of chemistry who contributed new knowledge and created new directions. This book presents the lives and times of 21 great chemists starting from Lavoisier (18th century) and ending with Sanger. Then, there are stories of the great Faraday (19th century) and of the 20th century geniuses G N Lewis and Linus Pauling. The material in the book is presented in the form of stories describing important aspects of the lives of these great personalities, besides highlighting their contributions to chemistry. It is hoped that the book will provide enjoyable reading and also inspiration to those who wish to understand the secret of the creativity of these great chemists.

Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology

Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology
Author: Andreas Hofmann
Publisher: Cambridge University Press
Total Pages: 962
Release: 2018-04-19
Genre: Science
ISBN: 1108365256

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Bringing this best-selling textbook right up to date, the new edition uniquely integrates the theories and methods that drive the fields of biology, biotechnology and medicine, comprehensively covering both the techniques students will encounter in lab classes and those that underpin current key advances and discoveries. The contents have been updated to include both traditional and cutting-edge techniques most commonly used in current life science research. Emphasis is placed on understanding the theory behind the techniques, as well as analysis of the resulting data. New chapters cover proteomics, genomics, metabolomics, bioinformatics, as well as data analysis and visualisation. Using accessible language to describe concepts and methods, and with a wealth of new in-text worked examples to challenge students' understanding, this textbook provides an essential guide to the key techniques used in current bioscience research.

Chemical Genomics

Chemical Genomics
Author: Haian Fu
Publisher: Cambridge University Press
Total Pages: 359
Release: 2012-02-13
Genre: Science
ISBN: 1107377587

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Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry.

The Telomere Effect

The Telomere Effect
Author: Dr. Elizabeth Blackburn
Publisher: Grand Central Publishing
Total Pages: 328
Release: 2017-01-03
Genre: Health & Fitness
ISBN: 1455587966

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The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free). The Telemere Effect reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. The Telemere Effect will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

Basic Biotechnology

Basic Biotechnology
Author: Colin Ratledge
Publisher: Cambridge University Press
Total Pages: 653
Release: 2006-05-25
Genre: Medical
ISBN: 0521840317

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Biotechnology is one of the major technologies of the twenty-first century. Its wide-ranging, multi-disciplinary activities include recombinant DNA techniques, cloning and the application of microbiology to the production of goods from bread to antibiotics. In this new edition of the textbook Basic Biotechnology, biology and bioprocessing topics are uniquely combined to provide a complete overview of biotechnology. The fundamental principles that underpin all biotechnology are explained and a full range of examples are discussed to show how these principles are applied; from starting substrate to final product. A distinctive feature of this text are the discussions of the public perception of biotechnology and the business of biotechnology, which set the science in a broader context. This comprehensive textbook is essential reading for all students of biotechnology and applied microbiology, and for researchers in biotechnology industries.

Wandering in the Gardens of the Mind

Wandering in the Gardens of the Mind
Author: John Prebble
Publisher: Oxford University Press
Total Pages: 368
Release: 2003-02-27
Genre: Science
ISBN: 9780195349559

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Peter Mitchell, winner of the 1978 Nobel Prize for chemistry for his chemiosmotic theory, was a highly original scientist who revolutionized our understanding of cellular metabolism and bioenergetics. This is the only full biography of Mitchell, and it should be of considerable interest to biophysicists, biochemists, and physicians and researchers focusing on metabolism, as well as historians of medicine and biology.