Breakpoint Analysis of Human Chromosome 3 Inversions During Hominoid Evolution

Breakpoint Analysis of Human Chromosome 3 Inversions During Hominoid Evolution
Author:
Publisher:
Total Pages:
Release: 2005
Genre:
ISBN:

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Comparative fluorescence in situ hybridization (FISH) mapping revealed four large DNA segments which have been conserved in their entirety between human chromosome 3 and Bornean orangutan chromosome 2 as well as three evolutionary breakpoints which distinguish between the human and Bornean orangutan chromosome forms. Examination of the structural and functional features of evolutionary breakpoints provides new insights into the possible effects of evolutionary rearrangements on genome function and the relationship between human chromosome pathology and evolution. FISH of human BAC clones which were assesssed in human genomic sequence to primate chromosomes, combined with precise breakpoint localizations by polymerase chain reaction (PCR) analysis of flow-sorted chromosomes and in silico analysis, were used to characterize the evolutionary breakpoints. None of the three breakpoints studied disrupts a validated gene(s), however they are all associated with segmental duplications. At least eleven DNA segments (& a.

Genomic Disorders

Genomic Disorders
Author: James R. Lupski
Publisher: Springer Science & Business Media
Total Pages: 419
Release: 2007-11-10
Genre: Medical
ISBN: 1597450391

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A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.

Index Medicus

Index Medicus
Author:
Publisher:
Total Pages: 1900
Release: 2002
Genre: Medicine
ISBN:

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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Mechanisms Driving Karyotype Evolution and Genomic Architecture

Mechanisms Driving Karyotype Evolution and Genomic Architecture
Author: Aurora Ruiz-Herrera
Publisher: MDPI
Total Pages: 248
Release: 2021-08-31
Genre: Science
ISBN: 3036501568

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Understanding of the origin of species and their adaptability to new environments is one of the main questions in biology. This is fueled by the ongoing debate on species concepts and facilitated by the availability of an unprecedented large number of genomic resources. Genomes are organized into chromosomes, where significant variations in number and morphology are observed among species due to large-scale structural variants such as inversions, translocations, fusions, and fissions. This genomic reshuffling provides, in the long term, new chromosomal forms on which natural selection can act upon, contributing to the origin of biodiversity. This book contains mainly articles, reviews, and an opinion piece that explore numerous aspects of genome plasticity among taxa that will help in understanding the dynamics of genome composition, the evolutionary relationships between species and, in the long run, speciation.

Genome Research

Genome Research
Author:
Publisher:
Total Pages: 910
Release: 2006
Genre: Genetics
ISBN:

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Atlas of Mammalian Chromosomes

Atlas of Mammalian Chromosomes
Author: Stephen J. O'Brien
Publisher: John Wiley & Sons
Total Pages: 544
Release: 2006-04-14
Genre: Science
ISBN: 0471779040

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A stunning visual collection of the banded metaphase chromosomekaryotypes from some 850 species of mammals, the Atlas of MammalianChromosomes represents an unabridged compendium of the state ofthis genomic art form. Bringing together information currentlyscattered throughout the cytogenetics literature for scores ofpublished and unpublished species, this atlas features high-qualitykaryotype images for nearly every mammal studied to date, making itthe most comprehensive assemblage of high-resolution chromosomephotographs available--a critically invaluable resource for today'scomparative genomics era. For every available species, the Atlas of Mammalian Chromosomespresents the best karyotype produced, the common and Latin name ofthe species, the published citation, and the contributing authors.Most karyotypes are G-banded, revealing the chromosomal bar codesof homologous segments among related species. Addressing the mandate of the Human Genome Project to annotate thegenomes of other organisms as well, the Atlas of MammalianChromosomes offers a step forward in our understanding of speciesformation, of genome organization, and of DNA script for naturalselection. It is an invaluable resource for geneticists,mammalogists, and biologists interested in comparative genomics,systematics, and chromosome structure.

C L

C L
Author:
Publisher:
Total Pages: 450
Release: 2004
Genre: Cells
ISBN:

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Signal Transduction and Communication in Cancer Cells

Signal Transduction and Communication in Cancer Cells
Author: H. Leon Bradlow
Publisher:
Total Pages: 532
Release: 2004
Genre: Medical
ISBN:

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In these proceedings for an October 2003 conference, contributors update topics and relevant issues in cancer research and clinical oncology, such as genetics, genomics, proteomics, signals and translational research in neuroectodermal timors, biomolecular surveying of cell signals, cell-to-cell communication, signals transduced by environmental and endogenous sex steroids, signals and molecular targets in human cancer tissues and cells, cell migration and adhesion, gene expression and silencing, and rational approaches to the design of therapeutics targeting molecular markers in hematologic malignancies. Topics of short papers include the induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors and a report from a registry comparing rates of breast cancer in the city and province of Palermo. Annotation ©2005 Book News, Inc., Portland, OR (booknews.com).

Cumulated Index Medicus

Cumulated Index Medicus
Author:
Publisher:
Total Pages: 1218
Release: 1986
Genre: Medicine
ISBN:

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