This paper presents a regional analysis of the answers reported in the Delphi study, titled “Some Elements of the Next Global Economic System over the Next 20 Years” and the goal of the study was: to identify new elements that might be included in a global economic system or affect its functioning over the next twenty years as a result of future developments. I participated as an economic expert in the Real Time Delphi organized by Dr. Jerome C. Glenn and Dr. Theodore Gordon of the annual “State of the Future” of the of the Millennium Project in Washington DC. Delphi methods are designed to evoke and assemble the general judgments and opinions of the particular group of experts engaged in a study. The Delphi study ended on May 3rd 2009 and covered 34 countries. The purpose of this paper is to present a regional analysis of the answers of the panel of experts that participated in the Real Time Delphi. I grouped the set of answers by country participation into 5 economic blocks based on the regional geographic definitions applied by the United Nations Organization. And then, I applied some basic comparative techniques and I quantified some basic aggregate relations among the answers of the panel of experts. I was interested in the regional perceptions about the needs and priorities for change in the next global economic system. I consider that some of my results could be of interest and they could contribute for the future Economic discussions and future international efforts that would be required to create “A New Global Economic System over the Next 20 years”. I do believe that the USA government leading the G7 and the G20 groups of nations and International Financial Institutions will have to define a long-term agenda in order to analyze, to define and to build the Next Global Economic and Financial Architecture (GEFA).