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| Author | : Marina Talib |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2012 |
| Genre | : |
| ISBN | : |
| Author | : Gilson Khang |
| Publisher | : World Scientific Publishing Company |
| Total Pages | : 289 |
| Release | : 2007-07-03 |
| Genre | : Science |
| ISBN | : 9813101601 |
Tissue engineering has been recognized as offering an alternative technique to whole-organ and tissue transplantation for diseased, failed, or malfunctioned organs. To reconstruct a new tissue via tissue engineering, the following triad components are needed: (1) cells which are harvested and dissociated from the donor tissue; (2) biomaterials as scaffold substrates in which cells are attached and cultured, resulting in implantation at the desired site of the functioning tissue; and (3) growth factors which promote and/or prevent cell adhesion, proliferation, migration, and differentiation. Of these three key components, scaffolds play a critical role in tissue engineering. This timely book focuses on the preparation and characterization of scaffold biomaterials for the application of tissue-engineered scaffolds. More importantly, it serves as an experimental guidebook on the standardization of the fabrication process and characterization of scaffolding technology.
| Author | : Muhamad Faiz Md Din |
| Publisher | : Trans Tech Publications Ltd |
| Total Pages | : 710 |
| Release | : 2022-01-28 |
| Genre | : Science |
| ISBN | : 3035732744 |
Selected peer-reviewed full text papers from the 10th International Conference on X-Rays and Related Techniques in Research and Industry (ICXRI 2021)
| Author | : Daniel X. B. Chen |
| Publisher | : Springer |
| Total Pages | : 171 |
| Release | : 2018-12-13 |
| Genre | : Technology & Engineering |
| ISBN | : 3030034607 |
This book introduces readers to the theory and practice of extrusion bio-printing of scaffolds for tissue engineering applications. The author emphasizes the fundamentals and practical applications of extrusion bio-printing to scaffold fabrication, in a manner particularly suitable for those who wish to master the subject matter and apply it to real tissue engineering applications. Readers will learn to design, fabricate, and characterize tissue scaffolds to be created by means of extrusion bio-printing technology.
| Author | : Paul Tomlins |
| Publisher | : Elsevier |
| Total Pages | : 296 |
| Release | : 2015-10-30 |
| Genre | : Technology & Engineering |
| ISBN | : 1782420959 |
Characterisation and Design of Tissue Scaffolds offers scientists a useful guide on the characterization of tissue scaffolds, detailing what needs to be measured and why, how such measurements can be made, and addressing industrially important issues. Part one provides readers with information on the fundamental considerations in the characterization of tissue scaffolds, while other sections detail how to prepare tissue scaffolds, discuss techniques in characterization, and present practical considerations for manufacturers. Summarizes concepts and current practice in the characterization and design of tissue scaffolds Discusses design and preparation of scaffolds Details how to prepare tissue scaffolds, discusses techniques in characterization, and presents practical considerations for manufacturers
| Author | : Manisha Shah |
| Publisher | : |
| Total Pages | : 110 |
| Release | : 2008 |
| Genre | : Biomedical engineering |
| ISBN | : |
"In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions. Successful tissue engineering of soft tissue largely depends on synthetic scaffolds that support the survival, proliferation and differentiation of seeded cells. In this investigation of the use of L-tyrosine based polyurethane in soft tissue engineering, three dimensional and 90% porous biodegradable polyurethane scaffolds with highly interconnected pore structure were fabricated by solvent casting and particulate leaching technique. Scaffolds were fabricated using ground and sieved sodium chloride particles. The grinding and sieving of sodium chloride resulted in particulates of uniform particle sizes but irregular shapes. Biodegradable L-tyrosine polyurethane scaffolds fabricated from these particulates had highly interconnected channels and the pores size that could allow cellular infiltration and nutrient delivery. The scaffolds had anisotropic pore structure with pore diameter ranging from 144-250um in diameter. Studies were conducted to investigate the effect of sodium chloride particulates on scaffold porosity and mean pore diameter. The study showed that scaffolds made using solvent casting and particulate leaching techniques demonstrated independent control of porosity and mean pore diameter of scaffold. Compression testing demonstrated mechanical anisotropy concomitant with the direction of the macro-pores. The porous architecture of these scaffolds reflected the mechanical anisotropy which was congruent with the scanning electron microscopy investigation. The results of this study showed that solvent casting and particulate leached (SPCL) L-tyrosine polyurethane scaffolds have great potential for use as a biodegradable tissue culture support devices. It is believed that, the porous polyurethane scaffold developed in this study will facilitate the construction of an implantable tissue engineered skin."--Abstract.
| Author | : Ying Deng |
| Publisher | : Woodhead Publishing |
| Total Pages | : 484 |
| Release | : 2017-10-17 |
| Genre | : Technology & Engineering |
| ISBN | : 0081009801 |
In order to grow replacement tissues, 3D scaffolds are widely used as a template for tissue engineering and regeneration. These scaffolds, which are typically ‘seeded’ with cells, support the growth of new tissues. However, in order to achieve successful tissue growth, the scaffold must meet specific requirements and are often ‘functionalized’ to accentuate particular properties. Functional 3D tissue engineering scaffolds: materials, technologies, and applications, is a comprehensive review of functional 3D scaffolds, providing information on the fundamentals, technologies, and applications. Part 1 focuses on the fundamentals of 3D tissue scaffolds, examining information on materials, properties, and trends. Part 2 discusses a wide range of conventional technologies for engineering functional 3D scaffolds, leading the way to a discussion on CAD and advanced technologies for functional 3D scaffold engineering. Chapters in part 3 study methods for functionalizing scaffolds to support a variety of in vivo functions whilst the final set of chapters provides an important review of the most significant applications of functional 3D scaffolds within tissue engineering. This book is a valuable resource for biomaterial scientists and biomedical engineers in academia and industry, with interests in tissue engineering and regenerative medicine. Provides a self-contained work for the field of biomaterials and tissue engineering Discusses all the requirements a scaffold must meet and a wide range of strategies to create them Highlights significant and successful applications of functional 3D scaffolds
| Author | : Mary Gazell Mapili Call |
| Publisher | : |
| Total Pages | : 402 |
| Release | : 2007 |
| Genre | : Microfabrication |
| ISBN | : |
Tissue engineering is a recently developed field that combines material science, cell biology, and engineering to create or improve functional tissues/organs. The field of tissue engineering has progressed from a fledgling science to an emerging technology, in large part due to parallel advances in the application of biomaterials and understanding stem cell behavior. Current studies have evaluated certain types of natural and synthetic biomaterials for feasibility of replicating the physio-chemical microenvironments of stem cells. Furthermore, technologies derived from micro-machining and solid free-form fabrication industries have utilized these biomaterials to create scaffolds that resemble tissue-like structures. Recent scaffold fabrication methods have attempted to overcome certain challenges in engineering tissues and organs. One of the fundamental limitations in current tissue engineering efforts has been the inability to develop multiple tissue types (i.e. bone, cartilage, muscles, ligaments) within a single scaffold structure in a predesigned manner. The differentiation of multiple cells within a three-dimensional (3D) scaffold using a single stem cell population has yet to be developed due to challenges in integrating various biochemical factors in a spatially-patterned method. This dissertation discusses scaffold micro-fabrication techniques that use layerby-layer, ultraviolet-based (UV) stereolithography systems. These approaches in microfabricating scaffolds provide an optimal, biomimetic environment for the pre-patterned differentiation of mesenchymal stem cells into skeletal-type tissues. We demonstrated both laser-based and digital micromirror device-based stereolithography systems for creating intricate scaffold architectures with multiple bio-factors encapsulated in predetermined regions. We showed that micro-stereolithography has the powerful capability of building 3D complex scaffolds with specific pore sizes and shapes in a layer-by-layer fashion using photo-crosslinkable monomers. These polymer-based scaffolds were functionalized with specific signaling proteins to create a biomimetic niche in which stem cells can respond, attach, and differentiate. The ultimate goal of this project is to integrate novel concepts of micro-manufacturing along with polymer-controlled release kinetics and stem cell biology to attain pre-designed architectures of tissue structures.
| Author | : Claudio Migliaresi |
| Publisher | : CRC Press |
| Total Pages | : 701 |
| Release | : 2014-06-10 |
| Genre | : Medical |
| ISBN | : 9814463205 |
Scaffolds for tissue engineering are devices that exploit specific and complex physical and biological functions, in vitro or in vivo, and communicate through biochemical and physical signals with cells and, when implanted, with the body environment. Scaffolds are produced mainly with synthetic materials, and their fabrication technologies are derived from already well-established industrial processes, with some new specific technologies having been developed in the last years to address required complexities. Often, a generalist approach is followed for the translation of materials and technologies designed for other applications, without considering the specific role of scaffolds from a physical and biological point of view. The book illustrates scaffold design principles, with particular relevance to the biological requirements needed to control and drive the biological cross talk, and reviews materials and fabrication and validation methods.
| Author | : Neeta Raj Sharma |
| Publisher | : Springer Nature |
| Total Pages | : 216 |
| Release | : 2021-04-21 |
| Genre | : Science |
| ISBN | : 9813368888 |
This book focuses on applications of three-dimensional (3D) printing in healthcare. It first describes a range of biomaterials, including their physicochemical and biological properties. It then reviews the current state of the art in bioprinting techniques and the potential application of bioprinting, computer-aided additive manufacturing of cells, tissues, and scaffolds to create organs in regenerative medicine. Further, it discusses the orthopedic applications of 3D printing in the design and fabrication of dental implants, and the use of 3D bioprinting in oral and maxillofacial surgery and in tissue and organ engineering. Lastly, the book examines the 3D printing technologies that are used for the fabrication of the drug delivery system. It also explores the current challenges and the future of 3D bioprinting in medical sciences, as well as the market demand.
