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| Author | : Siem van der Laan |
| Publisher | : |
| Total Pages | : 128 |
| Release | : 2008 |
| Genre | : |
| ISBN | : 9789064642944 |
| Author | : Rakesh Kumar |
| Publisher | : World Scientific |
| Total Pages | : 615 |
| Release | : 2008-03-14 |
| Genre | : Medical |
| ISBN | : 9814476056 |
This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the “classic” papers as well as perspectives on future directions for the field.
| Author | : Rakesh Kumar (Ph. D.) |
| Publisher | : World Scientific |
| Total Pages | : 615 |
| Release | : 2008 |
| Genre | : Medical |
| ISBN | : 9812819177 |
This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the OC classicOCO papers as well as perspectives on future directions for the field. Sample Chapter(s). Chapter 1: Nuclear Receptor Coregulators in Human Diseases (839 KB). Contents: Nuclear Receptor Coregulators in Human Diseases (R B Lanz et al.); p160 Coactivators: Critical Mediators of Transcriptional Activation by Nuclear Receptors (J H Kim & M R Stallcup); Regulation of Nuclear Hormone Receptor Functions by Ubiquitin-Proteasome Pathway (A Ismail et al.); Coregulators as Oncogenes and Tumor Suppressors (R Kumar & A E Gururaj); A Central Role of SRC-3/AIB1 in Tumorigenesis (J Yan et al.); Thyroid Hormone Receptors, Coregulators, and Disease (M L Privalsky); Androgen Receptor Coactivators in Prostate Cancer (N L Weigel & I U Agoulnik); PGC-1 and Metabolic Control in Skeletal and Cardiac Muscle (Z Arany & B M Spiegelman); Coregulators in Metabolic and Neurodegenerative Diseases (J N Feige et al.); Role of the RIP140 Corepressor in Metabolic Regulation (M G Parker et al.); Nuclear Receptor Corepressors and Metabolism (T Alenghat & M A Lazar); Coregulators in CNS Function and Disease (O C Meijer & E R de Kloet); Tissue Repair and Cancer Control Through PPARs and Their Coregulators (L Michalik & W Wahli); Coregulators and Inflammation (S Ghisletti & W Huang); Nuclear Receptor Coactivators in the Cardiovascular System (J-M Xu); Coregulators as Determinants of Selective Receptor Modulator (SRM) Activity (M C Pace & C L Smith); Coregulators in Toxicology (J Regg et al.); Nuclear Receptor Coactivators Co-ordinate Metabolic Responses to Hormonal and Environmental Stimuli (R M Evans et al.); Nuclear Receptor Cofactor Interactions as Targets for New Drug Discovery (L L Grasfeder & D P McDonnell). Readership: Academic, medical students, residents, fellow and biomedical research students."
| Author | : |
| Publisher | : |
| Total Pages | : 212 |
| Release | : 2012 |
| Genre | : |
| ISBN | : |
Sexual differentiation of the neonatal rat brain is regulated by a dynamic processes occurring at the level of DNA, resulting in sexually dimorphic gene expression. Steroid hormone receptors act partly in the developing brain by recruiting coregulatory proteins and other transcription factors that lead to altered gene expression. Recent data indicate that epigenetic processes play an important role in sexual differentiation of the brain. The dynamic interaction between epigenetic factors and chromatin leads to functional plasticity within the brain that may explain the diversity of responses to endogenous and exogenous signals. Subtle variations in these epigenetic factors may also partially explain individual differences in the development of neurological and mental health disorders. In this dissertation, I will explore the role of particular epigenetic factors during early postnatal brain development and their lasting impact on programming juvenile and adult behavior. We now show that both coactivators and corepressors are sexually dimorphic in the developing amygdala. Specifically, males express higher levels of Steroid Receptor Coactivator 1 (SRC-1) and CREB Binding Protein (CBP) than do females and females express higher levels of Nuclear Receptor Corepressor (NCoR) mRNA than do males. In addition, we have now shown that a transient, targeted disruption of NCoR within the developing amygdala has lasting consequences on juvenile social play, anxiety-like behaviors and social recognition. We also report that variations in the somatosensory stimuli associated with maternal grooming during the neonatal period alter expression levels of NCoR and Kaiso, but do not appear to affect expression levels of DISC1. Taken together, these data suggest a dynamic model of chromatin remodeling which may drive the organization of the developing rat brain.
| Author | : Malcolm G. Parker |
| Publisher | : |
| Total Pages | : 434 |
| Release | : 1991 |
| Genre | : Science |
| ISBN | : |
An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.
| Author | : Iain J. McEwan, PhD |
| Publisher | : Humana Press |
| Total Pages | : 0 |
| Release | : 2008-12-12 |
| Genre | : Science |
| ISBN | : 9781603275743 |
Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.
| Author | : Eric Shinnosuke Neff |
| Publisher | : |
| Total Pages | : 498 |
| Release | : 2007 |
| Genre | : |
| ISBN | : |
| Author | : Eckhard Ottow |
| Publisher | : Wiley-VCH |
| Total Pages | : 522 |
| Release | : 2008-10-13 |
| Genre | : Medical |
| ISBN | : 9783527318728 |
Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.
| Author | : Mostafa Z. Badr |
| Publisher | : Springer Nature |
| Total Pages | : 676 |
| Release | : 2021-09-28 |
| Genre | : Medical |
| ISBN | : 3030783154 |
Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 422 |
| Release | : 2017-05-17 |
| Genre | : Science |
| ISBN | : 0128021969 |
Nuclear Receptors in Development and Disease, Volume 125, the latest volume in the Current Topics in Developmental Biology series, covers nuclear receptors in development and disease, and includes contributions from an international board of authors. New chapters in this release cover the Evolution of Nuclear Receptors and Ligand Signaling: Towards a Soft Key–Lock Model?, The Function and Evolution of Nuclear Receptors in Insect Embryonic Development, Nuclear Receptors in Skeletal Homeostasis, Estrogen Hormone Biology, and the Mechanisms of Glucocorticoid Action During Development. The book's chapters provide a comprehensive set of reviews that cover such topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural development. Covers the area of nuclear receptors in development and disease Includes contributions from an International board of authors Provides a comprehensive set of reviews on topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural developments
