Experimentally Induced Immune Activation In Natural Hosts Of Siv Induces Significant Increases In Viral Replication And Cd4 T Cell Depletion
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Release | : 2008 |
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Download Experimentally-induced Immune Activation in Natural Hosts of SIV Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion Book in PDF, Epub and Kindle
Chronically SIVagm-infected African green monkeys (AGMs) have a remarkably stable non-pathogenic disease course, with levels of immune activation in chronic SIVagm infection similar to those observed in uninfected monkeys and stable viral loads (VLs) for long periods of time. In vivo administration of lipopolysaccharide (LPS) or an IL-2/diphtheria toxin fusion protein (Ontak) to chronically SIVagm-infected AGMs triggered increases in immune activation and subsequently of viral replication and depletion of intestinal CD4 T cells. Our study indicates that circulating microbial products can increase viral replication by inducing immune activation and increasing the number of viral target cells, thus demonstrating that immune activation and T cell prolifeation are key factors in AIDS pathogenesis.
Author | : Aftab A. Ansari |
Publisher | : Newnes |
Total Pages | : 415 |
Release | : 2014-07-04 |
Genre | : Medical |
ISBN | : 0124051677 |
Download Natural Hosts of SIV Book in PDF, Epub and Kindle
Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant. Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal models Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection
Author | : Gianfranco Pancino |
Publisher | : Academic Press |
Total Pages | : 362 |
Release | : 2011-12-02 |
Genre | : Medical |
ISBN | : 0123877156 |
Download Models of Protection Against HIV/SIV Book in PDF, Epub and Kindle
A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 200 |
Release | : 2011-12-05 |
Genre | : Science |
ISBN | : 0309220424 |
Download Chimpanzees in Biomedical and Behavioral Research Book in PDF, Epub and Kindle
For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.
Author | : Anthony S. Fauci |
Publisher | : Springer Science & Business Media |
Total Pages | : 159 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642608671 |
Download Immunopathogenesis of HIV Infection Book in PDF, Epub and Kindle
During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.
Author | : Martin Hoenigl |
Publisher | : Frontiers Media SA |
Total Pages | : 147 |
Release | : 2020-01-21 |
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ISBN | : 2889634388 |
Download HIV-Associated Immune Activation and Persistent Inflammation Book in PDF, Epub and Kindle
Author | : R. Ahmed |
Publisher | : Wiley-Blackwell |
Total Pages | : 754 |
Release | : 1999 |
Genre | : Medical |
ISBN | : |
Download Persistent Viral Infections Book in PDF, Epub and Kindle
Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.
Author | : Tamas Fulop |
Publisher | : Springer Science & Business Media |
Total Pages | : 1693 |
Release | : 2009-02-27 |
Genre | : Medical |
ISBN | : 1402090633 |
Download Handbook on Immunosenescence Book in PDF, Epub and Kindle
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Author | : Sunil Kannanganat Sidharthan |
Publisher | : Frontiers Media SA |
Total Pages | : 230 |
Release | : 2023-07-26 |
Genre | : Medical |
ISBN | : 2832530761 |
Download CD4 T cells in HIV: A friend or foe? Book in PDF, Epub and Kindle
Author | : |
Publisher | : Cambridge University Press |
Total Pages | : 361 |
Release | : |
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ISBN | : 0521782945 |
Download Savanna Monkeys Book in PDF, Epub and Kindle