Expanding the Scope of DNA-templated Organic Synthesis and in Vitro Selection
Author | : Thomas Marshall Snyder |
Publisher | : |
Total Pages | : 278 |
Release | : 2007 |
Genre | : Biochemical templates |
ISBN | : 9780549278948 |
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First, we describe a strategy for performing ordered multistep synthesis in a single solution. This system makes use of temperature-sensitive variations in DNA secondary structure to orchestrate an ordered multistep synthesis of a triolefin and a tripeptide in a single solution. This methodology provides a faster, higher-yielding route to multistep DNA-templated products and represents a mode of controlling chemical reactivity that is not accessible in traditional flask-based reaction formats.