Engineering the Genetic Code

Engineering the Genetic Code
Author: Nediljko Budisa
Publisher: John Wiley & Sons
Total Pages: 312
Release: 2006-05-12
Genre: Science
ISBN: 3527607099
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The ability to introduce non-canonical amino acids in vivo has greatly expanded the repertoire of accessible proteins for basic research and biotechnological application. Here, the different methods and strategies to incorporate new or modified amino acids are explained in detail, including a lot of practical advice for first-time users of this powerful technique. Novel applications in protein biochemistry, genomics, biotechnology and biomedicine made possible by the expansion of the genetic code are discussed and numerous examples are given. Essential reading for all molecular life scientists who want to stay ahead in their research.

The Triplet Genetic Code

The Triplet Genetic Code
Author: Lynn E. H. Trainor
Publisher: World Scientific
Total Pages: 144
Release: 2001
Genre: Science
ISBN: 9789810244682
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The purpose of this book is to bring to interested readers (professionals and laypersons alike) an appreciation and a basic understanding of what the genetic code is and why it has come to revolutionize thinking about living systems as a whole. The consequences of this revolution in molecular biology are so vast as to be almost incomprehensible. It seems important in a democratic society to have a citizenry well informed about the crucial issues of the day, such as genetic engineering and molecular medicine, which impact the social order and the ethos of society in such a profound way.This book discusses concisely the genetic code ? what it is and how it provides the key to molecular biology. The structures of DNA (as revealed by Watson and Crick) and of the various forms of RNA are described in some detail, and it is shown how these structures are marvellously adapted to the twin problems of inheritance of traits and faithful development of individual organisms. In this latter respect, the role of proteins as the ?molecules of life? is described and the central dogma of molecular biology (information flows from DNA to RNA to protein) elaborated. In addition, theories of the origin and development of the universal genetic code are reviewed briefly, and a perspective concerning the impact of molecular biology on the social ethos is presented.

Triplet Genetic Code, The: Key To Living Organisms

Triplet Genetic Code, The: Key To Living Organisms
Author: Lynn E H Trainor
Publisher: World Scientific
Total Pages: 141
Release: 2001-06-25
Genre: Science
ISBN: 9814492078
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The purpose of this book is to bring to interested readers (professionals and laypersons alike) an appreciation and a basic understanding of what the genetic code is and why it has come to revolutionize thinking about living systems as a whole. The consequences of this revolution in molecular biology are so vast as to be almost incomprehensible. It seems important in a democratic society to have a citizenry well informed about the crucial issues of the day, such as genetic engineering and molecular medicine, which impact the social order and the ethos of society in such a profound way.This book discusses concisely the genetic code — what it is and how it provides the key to molecular biology. The structures of DNA (as revealed by Watson and Crick) and of the various forms of RNA are described in some detail, and it is shown how these structures are marvellously adapted to the twin problems of inheritance of traits and faithful development of individual organisms. In this latter respect, the role of proteins as the “molecules of life” is described and the central dogma of molecular biology (information flows from DNA to RNA to protein) elaborated. In addition, theories of the origin and development of the universal genetic code are reviewed briefly, and a perspective concerning the impact of molecular biology on the social ethos is presented.

The Origin and Evolution of the Genetic Code: 100th Anniversary Year of the Birth of Francis Crick

The Origin and Evolution of the Genetic Code: 100th Anniversary Year of the Birth of Francis Crick
Author: Koji Tamura
Publisher: MDPI
Total Pages: 203
Release: 2018-03-23
Genre: Science
ISBN: 3038427691
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This book is a printed edition of the Special Issue "The Origin and Evolution of the Genetic Code: 100th Anniversary Year of the Birth of Francis Crick" that was published in Life

DNA & Genetic Engineering

DNA & Genetic Engineering
Author: Robert Snedden
Publisher: Capstone Classroom
Total Pages: 52
Release: 2007-08-25
Genre: Juvenile Nonfiction
ISBN: 9781432900397
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Looks at cells as life's building blocks, focusing on DNA and genetic engineering, discussing DNA as a cell's instruction manual, explaining how DNA is put together, and exploring some of the controversies surrounding genetic engineering and gene therapy.

The Code of Life

The Code of Life
Author: Alvin Silverstein
Publisher: Courier Corporation
Total Pages: 98
Release: 2004-01-01
Genre: Juvenile Nonfiction
ISBN: 0486439445
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Discusses chemical codes found in cells, their effects on the genes, and the role genes play in heredity.

Genetic Engineering of Plants

Genetic Engineering of Plants
Author: National Research Council
Publisher: National Academies Press
Total Pages: 97
Release: 1984-02-01
Genre: Science
ISBN: 0309034345
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"The book...is, in fact, a short text on the many practical problems...associated with translating the explosion in basic biotechnological research into the next Green Revolution," explains Economic Botany. The book is "a concise and accurate narrative, that also manages to be interesting and personal...a splendid little book." Biotechnology states, "Because of the clarity with which it is written, this thin volume makes a major contribution to improving public understanding of genetic engineering's potential for enlarging the world's food supply...and can be profitably read by practically anyone interested in application of molecular biology to improvement of productivity in agriculture."

Ctrl+Z Humanity: Rewriting the Genetic Code

Ctrl+Z Humanity: Rewriting the Genetic Code
Author: Shu Chen Hou
Publisher: Shu chen Hou
Total Pages: 100
Release:
Genre: Health & Fitness
ISBN:
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Embark on an extraordinary journey through the pages of "Ctrl+Z Humanity: Rewriting the Genetic Code" – a groundbreaking exploration that delves into the realms of genetic manipulation, synthetic organisms, and the profound possibilities of genetic medicine. This book is not just a collection of words; it's an odyssey of discovery, ethics, and inspiration that will reshape the way you perceive the power of genetics. 🧬 Unlock the Secrets: Dive into the fascinating world of genetics and unravel the mysteries that define life itself. From the intricacies of DNA to the frontiers of genetic manipulation, each page unveils a tapestry of knowledge that will leave you in awe. 🌱 Rewrite the Narrative: Explore the potential of synthetic organisms and de-extinction, where the boundaries of creation and conservation intertwine. Discover the ethical dilemmas that emerge when humans become architects of life, and contemplate the implications for biodiversity and ecosystems. 💉 Genetic Medicine Redefined: Immerse yourself in the revolution of personalized medicine, where genetic profiling leads to tailored treatments and disease prevention. Navigate the ethical considerations that guide the path to healing and wellbeing for individuals and societies alike. 🌌 Unveil the Future: Journey into the uncharted territories of genetic engineering and ponder the limitless horizons that beckon us. Contemplate the ethical complexities, technological limitations, and unforeseen consequences that shape the path ahead. 🌟 Be Part of the Conversation: "Ctrl+Z Humanity" isn't just a book; it's an invitation to join a global dialogue. Engage with the interplay of science, ethics, and policy-making that will determine the future of genetic innovation. Your voice matters in shaping the story of responsible genetic engineering. This book is more than an insight into genetics; it's an exploration of humanity's role as custodians of the genetic code. Whether you're a curious mind, a student of science, an advocate of ethics, or simply someone intrigued by the boundless possibilities of tomorrow, "Ctrl+Z Humanity" is your guide to understanding, contemplation, and inspiration. Embark on the Journey Today! Explore the book that has captivated minds and ignited conversations about the power and responsibility of genetic innovation. Order "Ctrl+Z Humanity: Rewriting the Genetic Code" and venture into the uncharted territories that define the future of life itself.

Pathway Engineering of the Expanding Genetic Code

Pathway Engineering of the Expanding Genetic Code
Author: John Christopher Anderson
Publisher:
Total Pages: 546
Release: 2003
Genre: Biochemistry
ISBN:
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Several projects focused on expanding the genetic code of Escherichia coli to include amino acids beyond the common twenty are described. These include the identification of extended codons, orthogonal pairs, and the engineering of amino acid metabolic pathways in E. coli . To incorporate multiple unnatural amino acids at distinct sites in a polypeptide, multiple noncoding codons are required. To this end efficiently-suppressed 4- and 5-base codons were identified using a selection strategy. To make use of these extended codons, three orthogonal aminoacyl-tRNA synthetase/suppressor tRNA pairs were engineered from archaebacteria. These systems do not cross-react with their E. coli homologs, but efficiently suppress UAG, AGGA, or UGA codons. Using a combination of saturation mutagenesis and genetic selection, several variants of the Pyrococcus horikoshii lysyl-tRNA synthetase were identified that permit the genetic encoding of homoglutamine in response to the codon AGGA in E. coli . In addition to adding new components to the translational machinery of E. coli , we have also added a biosynthetic pathways for p-aminophenylalanine providing the first example of an autonomous 21-amino acid organism that can biosynthesize an unnatural amino acid and incorporate it into protein with no media supplement. Finally, in an effort to incorporate [alpha]-hydroxy acids genetically into proteins we have identified strains deficient in their biotransformation to [alpha]-amino acids in E. coli . In combination with extended codons and orthogonal pairs, these strains set the stage for the evolution of a system that genetically encodes polyesters. The work described here not only allows us to generate proteins and possibly entire organisms with novel properties not restricted by the common twenty amino acids, it also provides an opportunity to explore basic mechanisms of translation.