With superior device performance consistently reported in extremely scaled dimensions, low dimensional materials (LDMs), including Carbon Nanotube Field Effect Transistor (CNFET) based technology, have shown the potential to outperform silicon for future transistors in advanced technology nodes. Studies have also demonstrated orders of magnitude improvement in energy efficiency possible with LDMs, in comparison to silicon at competing technology nodes. However, the current fabrication processes for these materials suffer from process imperfections and still appear to be inadequate to compete with silicon for the mainstream high volume manufacturing. Among the LDMs, CNFETs are the most widely studied and closest to high volume manufacturing. Recent works have shown a significant increase in the complexity of CNFET based systems, including demonstration of a 16-bit microprocessor. However, the design of such systems has involved significantly wider-than-usual transistors and avoidance of certain logic combinations. The resulting complexity of several thousand transistors in such systems is still far from the requirements of high-performance general-purpose computing systems having billions of transistors. With the current progress of the process to fabricate CNFETs, their introduction in mainstream manufacturing is expected to take several more years. For an earlier technology adoption, CNFETs appear to be suited for error-resilient computing systems where errors during computation can be tolerated to a certain degree. Such systems relax the need for precise circuits and a perfect process while leveraging the potential energy benefits of CNFET technology in comparison to conventional Si technology. In this thesis, we explore the potential applications using an imperfect CNFET process for error-resilient computing systems, including the impact of the process imperfections at the system level and methods to improve it. The current most widely adopted fabrication process for CNFETs (separation and placement of solution-based CNTs) still suffers from process imperfections, mainly from open CNTs due to missing of CNTs (in trenches connecting source and drain of CNFET). A fair evaluation of the performance of CNFET based circuits should thus take into consideration the effect of open CNTs, resulting in reduced drive currents. At the circuit level, this leads to failures in meeting 1) the minimum frequency requirement (due to an increase in critical path delay), and 2) the noise suppression requirement. We present a methodology to accurately capture the effect of open CNT imperfection in the state-of-the-art CNFET model, for circuit-level performance evaluation (both delay and glitch vulnerability) of CNFET based circuits using SPICE. A Monte Carlo simulation framework is also provided to investigate the statistical effect of open CNT imperfection on circuit-level performance. We introduce essential metrics to evaluate glitch vulnerability and also provide an effective link between glitch vulnerability and circuit topology. The past few years have observed significant growth of interest in approximate computing for a wide range of applications, including signal processing, data mining, machine learning, image, video processing, etc. In such applications, the result quality is not compromised appreciably, even in the presence of few errors during computation. The ability to tolerate few errors during computation relaxes the need to have precise circuits. Thus the approximate circuits can be designed, with lesser nodes, reduced stages, and reduced capacitance at few nodes. Consequently, the approximate circuits could reduce critical path delays and enhanced noise suppression in comparison to precise circuits. We present a systematic methodology utilizing Reduced Ordered Binary Decision Diagrams (ROBDD) for generating approximate circuits by taking an example of 16-bit parallel prefix CNFET adder. The approximate adder generated using the proposed algorithm has ~ 5x reduction in the average number of nodes failing glitch criteria (along paths to primary output) and 43.4% lesser Energy Delay Product (EDP) even at high open CNT imperfection, in comparison to the ideal case of no open CNT imperfection, at a mean relative error of 3.3%. The recent boom of deep learning has been made possible by VLSI technology advancement resulting in hardware systems, which can support deep learning algorithms. These hardware systems intend to satisfy the high-energy efficiency requirement of such algorithms. The hardware supporting such algorithms adopts neuromorphic-computing architectures with significantly less energy compared to traditional Von Neumann architectures. Deep Neural Networks (DNNs) belonging to deep learning domain find its use in a wide range of applications such as image classification, speech recognition, etc. Recent hardware systems have demonstrated the implementation of complex neural networks at significantly less power. However, the complexity of applications and depths of DNNs are expected to drastically increase in the future, imposing a demanding requirement in terms of scalability and energy efficiency of hardware technology. CNFET technology can be an excellent alternative to meet the aggressive energy efficiency requirement for future DNNs. However, degradation in circuit-level performance due to open CNT imperfection can result in timing failure, thus distorting the shape of non-linear activation function, leading to a significant degradation in classification accuracy. We present a framework to obtain sigmoid activation function considering the effect of open CNT imperfection. A digital neuron is explored to generate the sigmoid activation function, which deviates from the ideal case under imperfect process and reduced time period (increased clock frequency). The inherent error resilience of DNNs, on the other hand, can be utilized to mitigate the impact of imperfect process and maintain the shape of the activation function. We use pruning of synaptic weights, which, combined with the proposed approximate neuron, significantly reduces the chance of timing failures and helps to maintain the activation function shape even at high process imperfection and higher clock frequencies. We also provide a framework to obtain classification accuracy of Deep Belief Networks (class of DNNs based on unsupervised learning) using the activation functions obtained from SPICE simulations. By using both approximate neurons and pruning of synaptic weights, we achieve excellent system accuracy (only