Endocrine Disruption in Fish

Endocrine Disruption in Fish
Author: David E. Kime
Publisher: Springer Science & Business Media
Total Pages: 402
Release: 2012-12-06
Genre: Science
ISBN: 1461549434

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The last half-century has shown a dramatic increase in the standard of living of millions of people in Europe, North America and many parts of the Third World. This has, in many ways been brought about by scientific and technical developments which were initiated in the 1940s and 1950s. Promises were then made that nuclear energy would provide electricity so cheap that it would not need metering, pesticides would end malnutrition throughout the world and plastics and other synthetic chemicals would revolutionise our manufacturing industry and our way of life. Whilst some of these promises have been fulfilled, the problems of long-term health risks to humans and wildlife arising from the use, production and disposal of these products were either unknown or deliberately understated. Nuclear power is rendered economically unviable when the real cost of decommissioning and storage of waste for several millenia is included, and the effects on health of both humans and wildlife of early pest eradication programmes with organochlorine pesticides were well documented in Rachel Carson's "Silent Spring". Evidence of the effects of aerosols and refrigerants on depletion of the ozone layer has led to restriction on the use of CFCs, and there is now increasing evidence of climate change resulting from our profligate use of fossil fuels.

Endocrine Disruption in Fish

Endocrine Disruption in Fish
Author: David E. Kime
Publisher: Springer Science & Business Media
Total Pages: 416
Release: 1998-10-31
Genre: Medical
ISBN: 9780792383284

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The last half-century has shown a dramatic increase in the standard of living of millions of people in Europe, North America and many parts of the Third World. This has, in many ways been brought about by scientific and technical developments which were initiated in the 1940s and 1950s. Promises were then made that nuclear energy would provide electricity so cheap that it would not need metering, pesticides would end malnutrition throughout the world and plastics and other synthetic chemicals would revolutionise our manufacturing industry and our way of life. Whilst some of these promises have been fulfilled, the problems of long-term health risks to humans and wildlife arising from the use, production and disposal of these products were either unknown or deliberately understated. Nuclear power is rendered economically unviable when the real cost of decommissioning and storage of waste for several millenia is included, and the effects on health of both humans and wildlife of early pest eradication programmes with organochlorine pesticides were well documented in Rachel Carson's "Silent Spring". Evidence of the effects of aerosols and refrigerants on depletion of the ozone layer has led to restriction on the use of CFCs, and there is now increasing evidence of climate change resulting from our profligate use of fossil fuels.

Transcriptomic Analysis of Endocrine Disruption in Californian Sentinel Fish Species

Transcriptomic Analysis of Endocrine Disruption in Californian Sentinel Fish Species
Author:
Publisher:
Total Pages: 88
Release: 2012
Genre:
ISBN:

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Endocrine disruptors are the substances which disrupt the normal functioning of the endocrine system by interfering with the variety of hormone-regulated physiological pathways and causing adverse health effects on the organism's physiology. They include plasticizers, pesticides, detergents and pharmaceuticals. These substances find their way into rivers and the ocean through sewage discharge and sediments at the bottom. Humans are also exposed to these toxic chemicals owing to water and fish consumption. The pelagic fish, which are bottom feeders, are at the highest risk of exposure to these harmful chemicals which settle in ocean sediments. As evidence of the threat of endocrine disrupting chemicals (EDCs) is mounting, there is a need to revise our research and improve our diagnostic efforts. With the advent of high-throughput sequencing technologies, we can now look at the complete transcriptional characterization of an organism. Sentinel fish, indicators of the environmental hazards, provide assessment for the endocrine disrupting chemicals present in the marine environment. For this thesis project, the RNA-Sequencing data of Sardine, Mackerel and Turbot were analyzed to obtain detailed snapshots of the transcriptome in both control (unpolluted) and impacted (polluted) fish. The RNA-Seq analysis of the altered expression patterns of the genes involved in important metabolic and physiological processes will provide a powerful tool for obtaining complete picture of the endocrine disruption in aquatic organisms.

Histological Analysis of Endocrine Disruptive Effects in Small Laboratory Fish

Histological Analysis of Endocrine Disruptive Effects in Small Laboratory Fish
Author: Daniel Dietrich
Publisher: John Wiley & Sons
Total Pages: 272
Release: 2009-07-31
Genre: Technology & Engineering
ISBN: 9780470431788

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Timely title assembling the combined knowledge of some of the leading authorities in the field of small fish reproduction - an important topic for risk assessment and registration of chemical, agricultural, and pharmaceutical compounds Provides guidance on the microscopic structure of living tissue and evaluation of the reproductive glands of small laboratory fish Includes state-of-the-art science along with sufficient anatomical and physiological background for understanding and interpreting test results Helps standardize the interpretation of results from aquatic bioassays and field observations, which will also clarify inconsistencies in the current scientific literature Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

Hormonally Active Agents in the Environment

Hormonally Active Agents in the Environment
Author: National Research Council
Publisher: National Academies Press
Total Pages: 453
Release: 2000-02-03
Genre: Science
ISBN: 0309064198

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Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Endocrine Disruption in Fish

Endocrine Disruption in Fish
Author: Joakim Larsson
Publisher:
Total Pages: 160
Release: 2000
Genre: Endocrine toxicology
ISBN:

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Endocrine Disruption

Endocrine Disruption
Author: David O. Norris
Publisher: Oxford University Press
Total Pages: 492
Release: 2006
Genre: Medical
ISBN: 0195137493

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Addresses the biological effects of the large number of compounds that have been recognized as endocrine disrupters. This book presents the relevant fundamentals of the endocrine systems of animals and humans, the toxicology, developmental toxicology, ecology, and risk assessment methods, and lays out the state of understanding for the field.

Endocrine Disruptors in the Environment

Endocrine Disruptors in the Environment
Author: Sushil K. Khetan
Publisher: John Wiley & Sons
Total Pages: 410
Release: 2014-05-23
Genre: Technology & Engineering
ISBN: 1118891155

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Endocrine Disruptors in the Environment A concise and engaging overview of endocrine disruption phenomena that brings complex concepts within the reach of non-specialists For most of the last decade, the science of endocrine disruption has evolved with more definitive evidence of its damaging potential to health and environment. This book lists the major environmental chemicals of concern and their mechanism of endocrine disruption including remedial measures for them. Divided into three parts, Endocrine Disruptors in the Environment begins with an overview of the endocrine system and endocrine disruptors, discussing their salient features and presenting a historical perspective of endocrine disruption phenomena. It then goes on to cover hormone- signaling mechanisms, followed by various broad classes of putative endocrine disruptors, before introducing readers to environmental epigenetic modifications. Part two of the book focuses on removal processes of various EDCs by biotic and abiotic transformation/degradation. The last section consists of four chapters embracing themes on finding solutions to environmental EDCs—including their detection, regulation, replacement, and remediation. Endocrine Disruptors in the Environment is the first book to detail the endocrine effects of several known environmental contaminants and their mechanism of endocrine disruption. Additionally, it: Covers both the chemistry and biology of endocrine disruption and compiles almost all the known endocrine disrupting environmental chemicals and their mechanisms of toxicity Addresses policy and regulatory issues relevant to EDCs including scientific uncertainty and precautionary policy Brings forth the use of Green Chemistry principles in avoiding endocrine disruption in the designing and screening for safer chemicals and remediation of the EDCs in aquatic environment Includes a useful glossary of technical terms, a list of acronyms, topical references, and a subject index Endocrine Disruptors in the Environment is an ideal book for environmental chemists and endocrine toxicologists, developmental biologists, endocrinologists, epidemiologists, environmental health scientists and advocates, and regulatory officials tasked with risk assessment in environment and health areas.