Modified Cyclodextrins for Chiral Separation

Modified Cyclodextrins for Chiral Separation
Author: Weihua Tang
Publisher: Springer Science & Business Media
Total Pages: 266
Release: 2013-05-24
Genre: Science
ISBN: 3642376487

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Modified Cyclodextrins for Chiral Separation offers a review of the latest advances in developing modified cyclodextrins as chiral selectors for various chromatographic and electromigration techniques. Over the years, many descriptions of chiral separation have appeared in academic journals and books, but most of them have been devoted to either the development of analytical methods and protocols or the summary of different chiral selectors, including cyclodextrins for chiral separation applications. This is in marked contrast to this volume which focuses on the research endeavors concerning the development of cyclodextrin derivatives specifically as either chiral mobile phases for capillary electrophoresis, or chiral stationary phases for various chromatographic techniques including gas chromatography, or high-performance liquid chromatography and supercritical fluid chromatography. The ongoing thread in this book is the synthesis of structurally-defined cyclodextrin derivatives and their applications in enantiomer separation by means of different analytical techniques. Modified Cyclodextrins for Chiral Separation is intended for those who are interested in expanding their knowledge of cyclodextrin chemistry and chiral separation, and in what cyclodextrin modification can be made to suit the needs of chiral selectors for different analytical techniques. It primarily focuses on the state-of-the-art cyclodextrin chemistry which is the basis for all chiral selectors used in these chiral separation techniques. Weihua Tang, PhD, is a professor at the Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, China. Siu-Choon Ng, PhD, is a professor at the Division of Chemical and Biomedical Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore. Dongping Sun, PhD, is a professor at the Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, China.

Enantiomeric Separation of Alcohols by Gas Chromatography Using Cyclodextrin Derivatives as Stationary Phases

Enantiomeric Separation of Alcohols by Gas Chromatography Using Cyclodextrin Derivatives as Stationary Phases
Author: Ornuma Konghuirob
Publisher:
Total Pages: 216
Release: 2004
Genre: Alcohol
ISBN: 9789745314641

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Enantiomeric separations of 70 alcohols were studied by means of capillary gas chromatography using heptakis(2,3-di-O-¬methyl-6-O-tert-butyldimethylsilyl)cyclomaltoheptasose (or BSiMe) and octakis(2,3-di-O-¬methyl-6-O-tert-butyldimethylsilyl)cyclomaltooctaose (or GSiMe) as chiral stationary phases. The influence of analyte structure, e.g. the type and position of substituent, alcohol chain length, the position of chiral center, and main-structure of alcohols, on retention and enantioselectivity was systematically investigated. Thermodynamic data were also calculated to clarify the strength of analyte-stationary phase interaction and enantioselectivity towards the selected group of alcohols. All of alcohols studied, except for 35F and 2oct, were successfully separated with either BSiMe or GSiMe, or both of them. Generally, BSiMe phase exhibited grater enantioseparation towards most analytes than GSiMe phase. On both columns, the structure of alcohol analytes plays an important role on separation. Changing the position of substituent or chiral center causes changes in the interaction and enantioselectivity. The type and size of substituent also significantly affect enantioselectivity. In addition to the analyte structure, the size of cyclodextrin molecules greatly affects enantioselectivity.

Chiral Liquid Chromatography

Chiral Liquid Chromatography
Author: w Lough
Publisher: Springer Science & Business Media
Total Pages: 278
Release: 2012-12-06
Genre: Science
ISBN: 940090861X

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While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC). This need arises from the fact that, whereas previously it was very difficult to determine enantiomers by direct means, there is now a wide choice of direct LC methods. At the same time, regulatory authorities have been changing their attitudes towards the administration of pharmaceuticals as racemates, partly because it is now possible to study the individual enantiomers. Clearly this abundance of new information needs to be rationalized. More importantly, the chiral LC systems which are commercially available or readily accessible to the practising chromatographer needed to be reviewed and, to a much greater extent than in existing reviews or books, discussed in terms of their practical application. Accordingly this book is very much orientated towards the practical aspects of these commercially available and readily accessible chiral LC systems. To this end, it is written for practising chromatographers by a team of practising, experienced chromatographers who have spent many years tackling the problems presented by resolving enantiomers by LC. The practical aspects of common chiral LC systems cannot be fully understood if discussed in isolation.

Cyclodextrins in Chromatography

Cyclodextrins in Chromatography
Author: Tibor Cserháti
Publisher: Royal Society of Chemistry
Total Pages: 168
Release: 2007-10-31
Genre: Science
ISBN: 1847550673

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Cyclodextrins can form complexes with a wide variety of organic and inorganic compounds, a property which can prove useful when trying to separate complex mixtures. This book provides an up-to-date and critical evaluation of the application of cyclodextrins in many fields of chromatography (including thin layer, gas-liquid, high performance liquid and supercritical fluid chromatography; capillary electrophoresis; and isotacophoresis). Whilst mainly practical in nature, the book also looks briefly at the theoretical background for the various techniques. Any professional working with chromatography will welcome this unique book as both a practical compilation of methods and a source of reference to the literature regarding the use and impact of cyclodextrins in chromatography.

Enantiomeric Separation of Esters by Gas Chromatography Using Derivatized Bata-cyclodextrins as Stationary Phases

Enantiomeric Separation of Esters by Gas Chromatography Using Derivatized Bata-cyclodextrins as Stationary Phases
Author: Pattama Changseeplag
Publisher:
Total Pages: 238
Release: 2002
Genre: Cyclodextrins
ISBN: 9789741718962

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Enantiomeric separations of some esters were studied by means of capillary gas chromatography using heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl) cyclomaltoheptaose (or BSiMe) and heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)cyclomaltoheptaose (or BSiAc) as stationary phases. The influence of analyte structure, e.g. the type and position of substituent together with ester chain length, on retention and enantioselectivity was systematically investigated. Thermodynamic data were also calculated in order to clarify the strength of analyte-stationary phase interaction and enantioselectivity towards these selected groups of esters. All esters with different substitution patterns were successfully separated with either BSiMe or BSiAc, or otherwise both of them. Generally, BSiAc phase exhibited greater enantioselectivity towards most analytes than BSiMe phase. From chromatographic and thermodynamic data obtained, it can be concluded that the structure of ester analytes plays an important role on separation. In most cases, the interaction of these two phases towards esters slightly increased with lengthening alkyl chain while enantioselectivity significantly decreased. Also, changing the position of substituent or chiral center caused changes in the interaction and enantioselectivity. Moreover, the degrees of interaction strength and sites as well as enantioselectivity of these esters depended upon the size and polarity of substituents.

The Separation of Enantiomers by Capillary Electrophoresis

The Separation of Enantiomers by Capillary Electrophoresis
Author: Stephen Wren
Publisher: Springer Science & Business Media
Total Pages: 96
Release: 2013-04-17
Genre: Technology & Engineering
ISBN: 3322831418

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This book gives a comprehensive overview on the principles of physical and mathematical modelling of enantiomer separation by CE. Method development strategies are shown and cyclodextrins as a popular group of chiral selectors as well as some other selectors used as buffer additives for enantiomer separation in free solution are described.