Apolipoprotein E and Alzheimer’s Disease

Apolipoprotein E and Alzheimer’s Disease
Author: A.D. Roses
Publisher: Springer Science & Business Media
Total Pages: 208
Release: 2012-12-06
Genre: Medical
ISBN: 3642801099

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There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

Dementia with Lewy Bodies

Dementia with Lewy Bodies
Author: John O'Brien
Publisher: CRC Press
Total Pages: 286
Release: 2005-11-29
Genre: Medical
ISBN: 0203313909

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Filling a noticeable gap in the market for a new text solely focused on Dementia with Lewy Bodies, this book discusses cutting-edge topics covering the condition from diagnosis to management, as well as what is known about the neurobiological changes involved. With huge progress having been made over the last decade in terms of the disorder

Diabetes, Insulin and Alzheimer's Disease

Diabetes, Insulin and Alzheimer's Disease
Author: Suzanne Craft
Publisher: Springer Science & Business Media
Total Pages: 359
Release: 2010-03-10
Genre: Medical
ISBN: 3642043003

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This text provides a broad survey of the role of insulin in the brain. And it discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease.

Diabetes Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment

Diabetes Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment
Author: Enzo Bonora
Publisher: Springer
Total Pages: 0
Release: 2018-10-23
Genre: Medical
ISBN: 9783319450148

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This book provides the reader with comprehensive information on the epidemiology, etiology, pathogenesis, pathophysiology, clinical features, prevention, and treatment of diabetes with the aim of empowering health care providers in their daily battle against the disease. Diabetes has been identified by WHO and the United Nations as a medical emergency because of the increase in its global prevalence, which may reach one billion in three to four decades if the trend remains unchanged. Despite improved care that is helping to prolong life, diabetes impacts substantially on the quality of life of those affected and kills or disables several million people each year. The disease is systemic because all organs, tissues, and cells suffer in the presence of hyperglycemia and are damaged by the diabetic milieu. Unfortunately, most patients with diabetes will consequently experience chronic diabetic complications. This book, combining basic science with a practical clinical orientation, will be of value for all physicians and nurses who care for patients with diabetes.

Encyclopedia of Signaling Molecules

Encyclopedia of Signaling Molecules
Author: Sangdun Choi
Publisher: Springer
Total Pages: 6330
Release: 2017-12-15
Genre: Medical
ISBN: 9781493968008

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The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.

Neurodegeneration and Alzheimer's Disease

Neurodegeneration and Alzheimer's Disease
Author: Ralph N. Martins
Publisher: John Wiley & Sons
Total Pages: 548
Release: 2019-07-10
Genre: Technology & Engineering
ISBN: 1119356784

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Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.

Hypoglycemia in Diabetes

Hypoglycemia in Diabetes
Author: Philip Cryer
Publisher: American Diabetes Association
Total Pages: 194
Release: 2016-07-12
Genre: Medical
ISBN: 1580406491

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Intended for diabetes researchers and medical professionals who work closely with patients with diabetes, this newly updated and expanded edition provides new perspectives and direct insight into the causes and consequences of this serious medical condition from one of the foremost experts in the field. Using the latest scientific and medical developments and trends, readers will learn how to identify, prevent, and treat this challenging phenomenon within the parameters of the diabetes care regimen.

Modulation of Neuronal Insulin Signaling Rescues Axonal Transport Defects in an Alzheimer's Disease Model

Modulation of Neuronal Insulin Signaling Rescues Axonal Transport Defects in an Alzheimer's Disease Model
Author: Oliver Peter Takach
Publisher:
Total Pages: 0
Release: 2013
Genre: Alzheimer's disease
ISBN:

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Defective brain insulin signaling contributes to the cognitive deficits in Alzheimer's disease (AD). Oligomeric amyloid-[beta] peptides (A[beta]Os), the neurotoxin implicated in AD, induce a variety of cellular insults, including dysregulation of intracellular signaling cascades and disruption of fast axonal transport. I show that modulation of insulin signaling prevents A[beta]O-induced defects of brain-derived neurotrophic factor (BDNF) transport in wild type (tau+/+) and tau knockout (tau-/- ) primary hippocampal mouse neurons. Tideglusib, an inhibitor of glycogen synthase kinase-3[beta] (GSK3[beta]), an insulin signaling intermediate implicated in AD, rescues BDNF transport in tau+/+ and tau-/- neurons. Furthermore, Exendin-4, an anti-diabetes agent, activates the insulin signaling pathway through glucagon like peptide-1 receptor stimulation to also rescue BDNF transport defects similarly to Tideglusib. These results indicate a protective link between insulin signaling and tau-independent transport regulation. By establishing links between insulin signaling and A[beta]O action, my results allow for establishing novel directions for AD therapeutics.

Alzheimer's Disease

Alzheimer's Disease
Author: Jolanta Dorszewska
Publisher: BoD – Books on Demand
Total Pages: 164
Release: 2018-07-18
Genre: Medical
ISBN: 178923462X

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Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.

Gut Hormones

Gut Hormones
Author: Stephen Robert Bloom
Publisher:
Total Pages: 640
Release: 1981
Genre: Gastrointestinal hormones
ISBN:

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