Drug Metabolism Pharmacokinetics And Bioanalysis
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Author | : Hye Suk Lee |
Publisher | : MDPI |
Total Pages | : 230 |
Release | : 2019-06-12 |
Genre | : Medical |
ISBN | : 3038979163 |
Download Drug Metabolism, Pharmacokinetics and Bioanalysis Book in PDF, Epub and Kindle
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
Author | : Gary Evans |
Publisher | : CRC Press |
Total Pages | : 490 |
Release | : 2021-10-15 |
Genre | : Medical |
ISBN | : 1134477368 |
Download A Handbook of Bioanalysis and Drug Metabolism Book in PDF, Epub and Kindle
Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now. A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills. This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.
Author | : Siamak Cyrus Khojasteh |
Publisher | : Springer Science & Business Media |
Total Pages | : 222 |
Release | : 2011-04-07 |
Genre | : Medical |
ISBN | : 1441956298 |
Download Drug Metabolism and Pharmacokinetics Quick Guide Book in PDF, Epub and Kindle
Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
Author | : Hye Suk Lee |
Publisher | : |
Total Pages | : 230 |
Release | : 2019 |
Genre | : Medicine (General) |
ISBN | : 9783038979173 |
Download Drug Metabolism, Pharmacokinetics and Bioanalysis Book in PDF, Epub and Kindle
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug-drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
Author | : Joel Tärning |
Publisher | : |
Total Pages | : 61 |
Release | : 2007 |
Genre | : |
ISBN | : 9789162872335 |
Download Piperaquine Book in PDF, Epub and Kindle
Author | : Ragu Ramanathan |
Publisher | : John Wiley & Sons |
Total Pages | : 326 |
Release | : 2011-09-20 |
Genre | : Science |
ISBN | : 111821157X |
Download Mass Spectrometry in Drug Metabolism and Pharmacokinetics Book in PDF, Epub and Kindle
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Author | : Dennis A. Smith |
Publisher | : John Wiley & Sons |
Total Pages | : 207 |
Release | : 2006-08-21 |
Genre | : Medical |
ISBN | : 3527608281 |
Download Pharmacokinetics and Metabolism in Drug Design Book in PDF, Epub and Kindle
In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.
Author | : Peter L. Bonate |
Publisher | : Springer Science & Business Media |
Total Pages | : 648 |
Release | : 2005-12-05 |
Genre | : Medical |
ISBN | : 9780971176744 |
Download Pharmacokinetics in Drug Development Book in PDF, Epub and Kindle
These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. They fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.
Author | : Peter G. Welling |
Publisher | : Springer Science & Business Media |
Total Pages | : 546 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642786804 |
Download Pharmacokinetics of Drugs Book in PDF, Epub and Kindle
A compilation of researchers' experience in the areas of bioanalysis, pharmacokinetics, and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development, and clinical use. Contents cover descriptions of analytical methods, in vitro metabolism technology and membrane transport, reappraisal of classical pharmacokinetic problems, and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and pharmacokinetic software available for PCs.
Author | : Dennis A. Smith |
Publisher | : John Wiley & Sons |
Total Pages | : 269 |
Release | : 2012-05-14 |
Genre | : Medical |
ISBN | : 3527329544 |
Download Pharmacokinetics and Metabolism in Drug Design Book in PDF, Epub and Kindle
In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.