Drug Metabolism and Pharmacokinetics Quick Guide

Drug Metabolism and Pharmacokinetics Quick Guide
Author: Siamak Cyrus Khojasteh
Publisher: Springer Science & Business Media
Total Pages: 222
Release: 2011-04-07
Genre: Medical
ISBN: 1441956298

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Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Discovery DMPK Quick Guide

Discovery DMPK Quick Guide
Author: S. Cyrus Khojasteh
Publisher:
Total Pages: 0
Release: 2022
Genre:
ISBN: 9783031106927

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This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions.

Pharmacokinetics and Metabolism in Drug Design

Pharmacokinetics and Metabolism in Drug Design
Author: Dennis A. Smith
Publisher: John Wiley & Sons
Total Pages: 207
Release: 2006-08-21
Genre: Medical
ISBN: 3527608281

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In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Pharmacokinetics and Metabolism in Drug Design

Pharmacokinetics and Metabolism in Drug Design
Author: Dennis A. Smith
Publisher: John Wiley & Sons
Total Pages: 269
Release: 2012-09-13
Genre: Medical
ISBN: 3527645292

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In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

Pharmacokinetics in Drug Development

Pharmacokinetics in Drug Development
Author: Peter L. Bonate
Publisher: Springer Science & Business Media
Total Pages: 325
Release: 2011-02-21
Genre: Medical
ISBN: 1441979379

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The topics chosen for this volume were selected because they are some of the current development or technological issues facing drug development project teams. They regard the practical considerations for assessment of selected special development populations. For example, they include characterization of drug disposition in pregnant subjects, for measuring arrhythmic potential, for analysis tumor growth modeling, and for disease progression modeling. Practical considerations for metabolite safety testing, transporter assessments, Phase 0 testing, and development and execution of drug interaction programs reflect current regulatory topics meant to address enhancement of both safety assessment and early decision-making during new candidate selection. Important technologies like whole body autoradiography, digital imaging and dried blood spot sample collection methods are introduced, as both have begun to take a more visible role in pharmacokinetic departments throughout the industry.

Drug Metabolism Handbook

Drug Metabolism Handbook
Author: Ala F. Nassar
Publisher: John Wiley & Sons
Total Pages: 1059
Release: 2009-01-28
Genre: Medical
ISBN: 0470439254

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A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.

Discovery DMPK Quick Guide

Discovery DMPK Quick Guide
Author: S. Cyrus Khojasteh
Publisher: Springer Nature
Total Pages: 241
Release: 2022-12-12
Genre: Medical
ISBN: 3031106911

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This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions.

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists
Author: Younggil Kwon
Publisher: Springer Science & Business Media
Total Pages: 316
Release: 2001-12-31
Genre: Medical
ISBN: 0306462346

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This volume is a handbook primarily designed for scientists andtechnicians without formal pharmacokinetics/pharmacodynamics (PK/PD)training, who work in an industrial setting. The book is a primarydesktop reference and contains easy-to-understand guidance for PK/PDissues, study design, and data interpretation. PK/PD are integralaspects for investigating the disposition and pharmacological efficacyof drugs under various experimental and clinical conditions.

A Handbook of Bioanalysis and Drug Metabolism

A Handbook of Bioanalysis and Drug Metabolism
Author: Gary Evans
Publisher: CRC Press
Total Pages: 416
Release: 2004-05-15
Genre: Medical
ISBN: 9780415275200

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This stimulating new handbook examines the techniques, methodology and theory of bioanalysis and drug metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug-drug interactions. A Handbook of Bioanalysis and Drug Metabolism is an invaluable guide to senior undergraduates and postgraduates studying drug metabolism in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology - especially those considering industrial placements or a career in the biotechnology industry.