Drug Dna Interactions
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Author | : Kazuo Nakamoto |
Publisher | : John Wiley & Sons |
Total Pages | : 475 |
Release | : 2008-09-08 |
Genre | : Science |
ISBN | : 0470369167 |
Download Drug-DNA Interactions Book in PDF, Epub and Kindle
Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
Author | : Keith R. Fox |
Publisher | : Springer Science & Business Media |
Total Pages | : 296 |
Release | : 1997-10-07 |
Genre | : Medical |
ISBN | : |
Download Drug'DNA Interaction Protocols Book in PDF, Epub and Kindle
A collection of useful molecular techniques to illuminate and explore the interaction of drugs and ligands with DNA. These easily reproducible methods involve sequence recognition properties, as well as the physical approaches for measuring both the strength of interaction and the mode of drug binding to DNA. The interactions are also examined from a cellular perspective and for their usefulness in the design of new therapeutic agents. The powerful techniques detailed here will be particularly useful in elucidating the action of existing therapeutic agents, as well as in the design of new anti-cancer drugs with improved action and reduced toxicity.
Author | : Stephen Neidle |
Publisher | : CRC Press |
Total Pages | : 386 |
Release | : 1994-05-03 |
Genre | : Medical |
ISBN | : 9780849377730 |
Download Molecular Aspects of Anticancer Drug DNA Interactions Book in PDF, Epub and Kindle
This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
Author | : Catherine Anna Butler |
Publisher | : |
Total Pages | : 452 |
Release | : 1993 |
Genre | : Antineoplastic agents |
ISBN | : |
Download Spectroscopic Studies of Drug-DNA Interactions Book in PDF, Epub and Kindle
Author | : |
Publisher | : Elsevier |
Total Pages | : 740 |
Release | : 2001-07-31 |
Genre | : Medical |
ISBN | : 0080496903 |
Download Drug-Nucleic Acid Interactions Book in PDF, Epub and Kindle
This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.
Author | : |
Publisher | : |
Total Pages | : |
Release | : 1990 |
Genre | : |
ISBN | : |
Download Drug-DNA Interactions Book in PDF, Epub and Kindle
Author | : Biman Bagchi |
Publisher | : Cambridge University Press |
Total Pages | : 383 |
Release | : 2013-11-14 |
Genre | : Medical |
ISBN | : 1107037298 |
Download Water in Biological and Chemical Processes Book in PDF, Epub and Kindle
A unified overview of the dynamical properties of water and its unique and diverse role in biological and chemical processes.
Author | : |
Publisher | : |
Total Pages | : 412 |
Release | : 1992 |
Genre | : |
ISBN | : |
Download Modelling Studies on Drug-DNA Interactions Book in PDF, Epub and Kindle
Author | : Neidle |
Publisher | : CRC Press |
Total Pages | : 394 |
Release | : 1993-08-16 |
Genre | : Medical |
ISBN | : 9780849377709 |
Download Molecular Aspects of Anticancer Drug DNA Interaction Book in PDF, Epub and Kindle
This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
Author | : Fadwa Dhafer Hamad |
Publisher | : |
Total Pages | : 114 |
Release | : 2017 |
Genre | : DNA-binding proteins |
ISBN | : |
Download Novel Spectroscopic Tools to Differentiate Drug-DNA Binding Interactions Book in PDF, Epub and Kindle
DNA-drug interactions play a major role in therapeutics, diagnostics, forensics and imaging. Drugs bind to DNA in several ways based on the mode of interaction and they alter protein-DNA interactions or breaks/cleaves DNA that can lead to the cure of the disease. The major goal of the research carried out in this thesis is to develop novel optical spectroscopic tools that can differentiate Drug-DNA binding interactions mode whether its intercalation or minor-groove binding. To achieve this goal, we developed two-photon absorption (2PA) cross-section based technique to differentiate between Drug-DNA binding modes. The investigations were carried out on two drug molecules, DAPI and Thiazole Orange (ThO) binding to Salmon Sperm-DNA and Calf Thymus-DNA. DAPI binds to the DNA via minor-groove while ThO intercalates with DNA. Relative 2PA cross-section studies have shown about 3-fold enhancement for DAPI whereas ThO has shown no enhancement. These results confirmed our hypothesis. To further establish this method, studies were carried out using two more drug molecules, Netropsin and Doxorubicin with Salmon Sperm-DNA. Netropsin is a non-fluorescent drug that required a marker to read its binding interaction with DNA. Two types of markers have been used, Hoechst-33258 was used as minor-groove marker and Thioflavine T as intercalator. Doxorubicin drug is fluorescent and the binding results via the 2PA cross-sections have shown a slight decrease in 2PA-fluorescence, suggesting the intercalation binding mode with DNA.