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| Author | : Gabriella Mazzotta |
| Publisher | : Frontiers Media SA |
| Total Pages | : 185 |
| Release | : 2021-04-01 |
| Genre | : Science |
| ISBN | : 2889666565 |
| Author | : Josh Dubnau |
| Publisher | : Cambridge University Press |
| Total Pages | : 309 |
| Release | : 2014-06-26 |
| Genre | : Science |
| ISBN | : 1139952196 |
The common fruit fly - Drosophila melanogaster - has been the subject of genetics research since the early twentieth century. The complete genomic sequence of Drosophila was published in 2000 and it is still the model organism par excellence for the experimental study of biological phenomena and processes. It is also by far the best model for studying gene function in mammals, including humans. Presenting state-of-the-art studies on the behaviour of Drosophila, this volume discusses normal and pathological models of neurobehavioral disorders and encompasses the specialised methods that have been used, from anatomical, histological, immunohistological and neurophysiological to genomic, genetic and behavioural assays. A comprehensive and thorough reference, this volume is a valuable resource for students and researchers alike across several disciplines of life sciences, including behavioral genetics, neurogenetics, behavioral neuroscience, molecular biology, evolutionary biology and population biology.
| Author | : R. J. Greenspan |
| Publisher | : |
| Total Pages | : 346 |
| Release | : 1994 |
| Genre | : Medical |
| ISBN | : |
Animal behaviors are among the most diverse and complex products of evolution. They represent a major source of variation both within and between populations. As with all aspects of evolution, there are boundaries that determine the freedom of behavioral characteristics to vary. To understand the causes and consequences of such variation, it is essential to define these boundaries. Defining them, in turn, requires that we understand the biological substrates of behavior and how they are subject to variation. In this unique volume, 58 international experts attempt to analyze and discuss the elements of behavior at many different levels and from many different disciplines. By focusing on the flexible and constrained aspects of behavior, they have been able to look for common themes in the biological strategies for organizing and producing behavior that exist at molecular, physiological, and evolutionary levels. They discuss the role of development and circuit modulation, as well as the versatile roles of individual genes and individual cells in them. Throughout, they have taken an integrative look at a subject that demands this kind of approach. This volume should be of interest to behaviorists, neuroscientists, behavioral ecologists, and psychologists. Goal of this Dahlem Workshop: to examine the factors contributing to flexibility and constraint in behavior (molecular, genetic, physiological, evolutionary) and to explore their contribution to a deeper understanding of the interplay between behavior and evolution.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 347 |
| Release | : 2000-11-21 |
| Genre | : Nature |
| ISBN | : 0309171806 |
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
| Author | : Dan L. Lindsley |
| Publisher | : Academic Press |
| Total Pages | : 1144 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0323139841 |
Dedicated to the memory of George Lefevre in recognition of his exhaustive cytogenetic analysis of the X chromosome, The Genome of Drosophila melanogaster is the complete compendium of what is known about the genes and chromosomes of this widely used model organism. The volume is an up-to-date revision of Lindsley and Grell's 1968 work, Genetic Variations of Drosophila melanogaster. The new edition contains complete descriptions of normal and mutant genes including phenotypic, cytological, molecular, and bibliographic information. In addition, it describes thousands of recorded chromosome rearrangements used in research on Drosophila. This handbook and its accompanying polytene chromosome maps, are sturdily bound into the book as foldouts and available as a separate set, are essential research tools for the Drosophila community. Describes phenotype, cytology, and molecular biology of all recorded genes of Drosophila melanogaster, plus references to the literature Describes normal chromosome complement, special chromosome constructs, transposable elements, departures from diploidy, satellite sequences, and nonchromosomal inheritance Describes all recorded chromosome rearrangements of Drosophila melanogaster as of the end of 1989 Contains the cytogenetic map of all genes as of mid-1991 Contains the original polytene maps of C.B. Bridges, plus G. Lefevre's photographic equivalents, and the detailed maps of the chromosome arms produced by C.B. and P.M. Bridges All maps are reprinted as high-quality foldouts sturdily bound into the volume Maps may also be purchased separately in an eight-map packet, for laboratory and student use
| Author | : Bruce Alberts |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2002 |
| Genre | : Cytology |
| ISBN | : 9780815332183 |
| Author | : Mikhail Soloviev |
| Publisher | : John Wiley & Sons |
| Total Pages | : 432 |
| Release | : 2007-12-21 |
| Genre | : Science |
| ISBN | : 0470196491 |
The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.
| Author | : Robert E. Kohler |
| Publisher | : University of Chicago Press |
| Total Pages | : 337 |
| Release | : 1994-05-02 |
| Genre | : Science |
| ISBN | : 0226450635 |
"One of the most productive of all laboratory animals, Drosophila has been a key tool in genetics research for nearly a century. At the center of Drosophila culture from 1910 to 1940 was the school of Thomas Hunt Morgan and his students Alfred Sturtevant and Calvin Bridges, who, by inbreeding fruit flies, created a model laboratory creature - the 'standard' fly. By examining the material culture and working customs of Morgan's research group, [the author] brings to light essential features of the practice of experimental science. [This book] takes a broad view of experimental work, ranging from how the fly was introducted into the laboratory and how it was physically redesigned for use in genetic mapping, to how the 'Drosophilists' organized an international network for exchanging fly stocks that spread their practices around the world"--Back cover.
| Author | : Wu-Min Deng |
| Publisher | : Springer Nature |
| Total Pages | : 251 |
| Release | : 2019-09-13 |
| Genre | : Medical |
| ISBN | : 3030236293 |
This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 507 |
| Release | : 2015-01-30 |
| Genre | : Science |
| ISBN | : 0128013419 |
Two new volumes of Methods in Enzymology continue the legacy of this premier serial with quality chapters authored by leaders in the field. Circadian Rhythms and Biological Clocks Part A and Part B is an exceptional resource for anybody interested in the general area of circadian rhythms. As key elements of timekeeping are conserved in organisms across the phylogenetic tree, and our understanding of circadian biology has benefited tremendously from work done in many species, the volume provides a wide range of assays for different biological systems. Protocols are provided to assess clock function, entrainment of the clock to stimuli such as light and food, and output rhythms of behavior and physiology. This volume also delves into the impact of circadian disruption on human health. Contributions are from leaders in the field who have made major discoveries using the methods presented here. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Keeping with the interdisciplinary nature of the circadian rhythm field, the volume includes diverse approaches towards the study of rhythms, from assays of biochemical reactions in unicellular organisms to monitoring of behavior in humans.
