DNA repair and immune response

DNA repair and immune response
Author: Niels Olsen Saraiva Camara
Publisher: Frontiers Media SA
Total Pages: 163
Release: 2023-01-27
Genre: Medical
ISBN: 2832505147

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Photoimmunology

Photoimmunology
Author: Jean Krutmann
Publisher: Wiley-Blackwell
Total Pages: 303
Release: 1995
Genre: Medical
ISBN: 9780865428263

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The skin immune response/photoallergy/photoimmunology of lupus/UV & infectious disease/therapeutic photoimmunology.

Dna Deamination And The Immune System: Aid In Health And Disease

Dna Deamination And The Immune System: Aid In Health And Disease
Author: Nina Papavasiliou
Publisher: World Scientific
Total Pages: 232
Release: 2010-10-27
Genre: Science
ISBN: 1908977949

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This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome? These questions, among others, will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued title summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments./a

Microbial Toxins

Microbial Toxins
Author: P. Gopalakrishnakone
Publisher: Springer
Total Pages: 502
Release: 2018-03-14
Genre: Medical
ISBN: 9789400764484

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In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Biological Responses to DNA Damage

Biological Responses to DNA Damage
Author:
Publisher: CSHL Press
Total Pages: 680
Release: 2000
Genre: DNA damage
ISBN: 9780879696061

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Living cells have evolved many ways of coping with metabolic events and environmental influences that damage DNA. These mechanisms, and the frequent progression to cancer that results when they go awry, are rev iewed in this volume by authors from over sixty of the world's leading laboratories. The topics discussed include DNA repair, mutagenesis and other damage-tolerance functions, checkpoint control, apoptosis, and adaptation. They draw from studies on human and yeast cells. Current, but with a valuable historical perspective, this volume has the depth and lasting value typical of this most prestigious series and is esse ntial reading for investigators of DNA replication, cell cycle control, and tumorigenesis.