Developmental Toxicity Of Otto Fuel Ii In The Rat And Rabbit
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Total Pages | : 7 |
Release | : 1993 |
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Download Developmental Toxicity of OTTO Fuel II in the Rat and Rabbit Book in PDF, Epub and Kindle
OTTO Fuel II (OFII) is a propellent used by the United States Navy in its Mk 46 and Mk 48 torpedoes. Owing to the possibility of human exposure during fueling and defueling operations, studies were initiated to determine if OFII was a developmental toxin. Phase I of the investigation involved dosing four groups of time-mated Fischer-344 rats with OFII. The fuel was administered dermally at the rate of 0, 400, 2000 and 4000 mg/kg/day. A significant reduction in body weight was seen at necropsy in dams receiving 2000 and 4000 mg/kg/day of OFII. Fetuses from these dams also weighed significantly less than control fetuses. Phase II of the investigation involved dosing of artificially inseminated rabbits with OFII. The fuel was administered to the skin of the animal's back at the rate of 0, 100, 316 and 1000 mg/kg/day. Maternal toxicity was evidenced by a significant reduction in body weight of the dams in the 1000 mg/kg/day dose group on days 20 and 25 of gestation. There were no significant differences observed in maternal weight or fetal weight at necropsy. Morphological examination of both rat and rabbit fetuses faded to reveal significant evidence of fetal malformations. OTTO Fuel II, Teratology, Rat, Rabbit, Propylene Glycol Dinitrate (PGDN).
Author | : |
Publisher | : |
Total Pages | : 206 |
Release | : 1995 |
Genre | : Explosives industry |
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Download Toxicological Profile for Otto Fuel II and Its Components Book in PDF, Epub and Kindle
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 292 |
Release | : 2002-11-07 |
Genre | : Political Science |
ISBN | : 030908511X |
Download Acute Exposure Guideline Levels for Selected Airborne Chemicals Book in PDF, Epub and Kindle
This book reviews toxicity documents on five chemicals that can be released in the air from accidents at chemical plants, storage sites, or during transportation. The documents were prepared by the National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances and were evaluated for their scientific validity, comprehensives, internal consistency, and conformance to the 1993 guidelines report.
Author | : |
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Total Pages | : 1480 |
Release | : 1976 |
Genre | : Medicine |
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Download Cumulated Index Medicus Book in PDF, Epub and Kindle
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Total Pages | : 1496 |
Release | : 1994 |
Genre | : Science |
ISBN | : |
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Total Pages | : 1144 |
Release | : 1994 |
Genre | : Government reports announcements & index |
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Author | : |
Publisher | : Royal Society of Chemistry |
Total Pages | : 984 |
Release | : 1999 |
Genre | : Pollution |
ISBN | : 9780854048335 |
Download The Dictionary of Substances and Their Effects Book in PDF, Epub and Kindle
Author | : |
Publisher | : |
Total Pages | : 500 |
Release | : 1995 |
Genre | : Polycyclic aromatic hydrocarbons |
ISBN | : |
Download Toxicological Profile for Polycyclic Aromatic Hydrocarbons Book in PDF, Epub and Kindle
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 292 |
Release | : 2002-10-07 |
Genre | : Political Science |
ISBN | : 0309182700 |
Download Acute Exposure Guideline Levels for Selected Airborne Chemicals Book in PDF, Epub and Kindle
This book reviews toxicity documents on five chemicals that can be released in the air from accidents at chemical plants, storage sites, or during transportation. The documents were prepared by the National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances and were evaluated for their scientific validity, comprehensives, internal consistency, and conformance to the 1993 guidelines report.
Author | : Royal Society of Chemistry (Great Britain) |
Publisher | : |
Total Pages | : 1116 |
Release | : 1992 |
Genre | : Medical |
ISBN | : |
Download The Dictionary of Substances and Their Effects Book in PDF, Epub and Kindle
Dictionary of Substances and their Effects (DOSE) is a major reference work of specialist data on chemicals with environmental impact. DOSE includes data for the accurate assessment of the risks associated with the use of over 4,100 chemicals.