Cyclic Nucleotide Phosphodiesterases
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Author | : Joseph A. Beavo |
Publisher | : CRC Press |
Total Pages | : 728 |
Release | : 2006-12-05 |
Genre | : Medical |
ISBN | : 1420020846 |
Download Cyclic Nucleotide Phosphodiesterases in Health and Disease Book in PDF, Epub and Kindle
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Author | : XiaoDong Cheng |
Publisher | : CRC Press |
Total Pages | : 288 |
Release | : 2021-03-30 |
Genre | : Cellular signal transduction |
ISBN | : 9780367658809 |
Download Cyclic Nucleotide Signaling Book in PDF, Epub and Kindle
Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.
Author | : Suresh C Sikka |
Publisher | : Academic Press |
Total Pages | : 638 |
Release | : 2017-11-14 |
Genre | : Medical |
ISBN | : 0128013133 |
Download Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health Book in PDF, Epub and Kindle
Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health is structured into two parts related to men’s reproductive and sexual health with eight sections designed to enable a logical flow of such knowledge. The book is focused on the biology of key organs involved in male reproduction and the environmental influences affecting their functions with particular emphasis on clinical aspects. Individual chapters within the book range from basic to translational aspects, but all hold clinical relevance. This is an essential reference for those working and learning in the field of human reproduction, reproductive toxicology and environmental influences on reproductive and sexual health. Brings together the leading authorities working in the field of male reproduction and sexual health and how the environment affects these issues Provides guidelines and reference values of various reproductive hormones, semen parameters, inclusion/exclusion criteria for clinical trials Discover the most efficient methods by which to design clinical protocols for sperm safety studies and reproductive toxicology trials
Author | : Nicholas J. Brandon |
Publisher | : John Wiley & Sons |
Total Pages | : 429 |
Release | : 2014-03-07 |
Genre | : Medical |
ISBN | : 1118836308 |
Download Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System Book in PDF, Epub and Kindle
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
Author | : J. Beavo |
Publisher | : |
Total Pages | : 0 |
Release | : 1990 |
Genre | : |
ISBN | : |
Download Cyclic Nucleotide Phosphodiesterases Book in PDF, Epub and Kindle
Author | : Joe Beavo |
Publisher | : |
Total Pages | : 368 |
Release | : 1990-11-30 |
Genre | : Medical |
ISBN | : |
Download Cyclic Nucleotide Phosphodiesterases Book in PDF, Epub and Kindle
Second volume in a series addressing topical areas important to the understanding of the control of biological processes. This volume focuses on the structure and molecular biology of isoenzymes and their role in signal transduction processes necessary for co-ordinating cellular functioning.
Author | : Bertil B. Fredholm |
Publisher | : Springer Science & Business Media |
Total Pages | : 566 |
Release | : 2010-09-22 |
Genre | : Medical |
ISBN | : 3642134432 |
Download Methylxanthines Book in PDF, Epub and Kindle
In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline. A special chapter is devoted to theobromine, an active component of chocolate, the actions of which are less well characterized. This book also presents the pharmacology of one xanthine derivative, propentofylline, as an example of a xanthine that has gone through extensive development for a novel therapeutic area.
Author | : |
Publisher | : Elsevier |
Total Pages | : 247 |
Release | : 1996-08-16 |
Genre | : Science |
ISBN | : 0080538819 |
Download Phosphodiesterase Inhibitors Book in PDF, Epub and Kindle
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Utilizes actual testing and research of new PDE inhibitors Valuable for researchers and students alike
Author | : Claire Lugnier |
Publisher | : Springer Science & Business Media |
Total Pages | : 327 |
Release | : 2008-02-04 |
Genre | : Science |
ISBN | : 1592598390 |
Download Phosphodiesterase Methods and Protocols Book in PDF, Epub and Kindle
Research leaders in the PDE field describe new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. Presented in step-by-step detail, these readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatio-temporal manner, the localization and characterization of their activities in tissues and living cells, and the assessment of targeted PDEs in creating specific tools and drugs.
Author | : Lena Josefine Daumann |
Publisher | : Springer |
Total Pages | : 253 |
Release | : 2014-05-28 |
Genre | : Technology & Engineering |
ISBN | : 3319066293 |
Download Spectroscopic and Mechanistic Studies of Dinuclear Metallohydrolases and Their Biomimetic Complexes Book in PDF, Epub and Kindle
Lena Daumanns's thesis describes structural and functional studies of the enzyme Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. It also examines the properties of small mimics of this enzyme and related binuclear metallohydrolases such as the metallo-ß-lactamases to enhance our understanding of hydrolytic cleavage of important substrates like phosphoesters and β-lactams. Overall, this project has led to a better understanding of the metal ion binding and active site structural features of the enzyme GpdQ. Daumann describes how she successfully immobilized phosphoesterase and related biomimetics on solid supports for potential applications in the area of bioremediation of organophosphate pesticides. Analysis shows that both the enzyme and biomimetics can be stored on the solid support without loss of activity. Furthermore, the author specroscopically and mechanistically characterized a number of Zn(II), Cd(II) and Co(II) complexes, some of which are among the most active biomimetics towards organophosphates reported to date. This thesis makes excellent reading for non-specialists because each chapter includes a short introduction section.