Control of Multiple Magnetic Microrobots for Biomedical Applications

Control of Multiple Magnetic Microrobots for Biomedical Applications
Author: Mohammad Salehizadeh
Publisher:
Total Pages: 0
Release: 2020
Genre:
ISBN:

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My PhD dissertation takes an innovative approach to using the fundamental tools of robotics and control to solve the underactuated control problem of multiple magnetic microrobots for biomedical applications. The ability to use a team of microrobots to run a task can offer many advantages. However, the integration of on-board powering and sensing circuitry has not yet become possible at the microscale. Therefore, all magnetic microrobots (micro-agents) of the team have to share a single driving signal, whereas the system has multiple states to be independently controlled. Another major challenge with magnetic team control is that when multiple magnetic microrobots work together in close proximity, the agents tend to irreversibly stick together due to strong magnetic inter-agent forces. Previous studies either ignored the inter-agent forces by simply assuming their robots were far apart or treated these forces as disturbances without verifying the stability in close proximity. I solved for the first time this problem for a pair of magnetic agents in close proximity in 2D (and later in 3D) by making full use of inter-agent forces to control the motion of agents. In my approach, the positions of microrobots were controlled independently. As a practical demonstration, I showed for the first time that the motion of two functional magnetic microrobots as microgrippers can be controlled in 3D to run a task. Subsequently, to generalize the inter-agent force control to more agents, I introduced two solutions: 1) via optimization-based control (as a control technique), and 2) via motion planning and tracking (as a robotics technique). My PhD research enabled for the first time the collision-free autonomous navigation of a team of magnetic microrobots in close proximity. This solution allows magnetic microrobots to potentially act in a cluttered environment, such as the human body or microfluidic channels. To this end, I employed rapidly-exploring random tree (RRT) motion planning. I further incorporated the idea to run two practical demos that could be applied to cell testing/manipulation. The results of this PhD work can be applied to actuation and sensing, especially in the design of field-activated medical devices and for localized targeted drug delivery.

Cooperative Control of Multiple Untethered Magnetic Microrobots for Precision Micromanipulation

Cooperative Control of Multiple Untethered Magnetic Microrobots for Precision Micromanipulation
Author: Nahum Arenas Torres
Publisher:
Total Pages: 138
Release: 2019
Genre: Manipulators (Mechanism)
ISBN:

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The field of untethered microrobotics has emerged within the last two decades for its applications potential in military surveillance, micro and nano manufacturing, as well as in health care for minimal invasive surgery and drug delivery. Microrobots need to be fast and precise in order to be useful as a tool for manufacturing applications. It is well understood that at this size scale numerous challenges prevail such as stiction between microrobot and environment, providing power, locomotion control, and intelligence to microrobots and motion measurement. In order to accelerate the research in this field, I participated in the Mobile Microrobotics Challenge (MMC). MMC is an annual event organized by the Institute of Electrical and Electronics Engineers Robotics and Automation Society (IEEE RAS) since 2013 and designed to encourage researchers around the world to solve pressing challenges in microrobotics. The challenge is composed of three events: 1) the autonomous mobility and accuracy challenge, 2) the microassembly challenge and 3) the MMC showcase and poster session. These challenges simulate common tasks that are found in medical applications, involving high speed closed-loop positioning, and in microassembly applications involving precision motion control and the later and the showcase and poster challenge tests your communication skills. This thesis investigates and provides methods to mitigate the problems of stiction, locomotion control, and motion measurement for microrobots. In addition, we discuss novel methods for providing cooperative behavior to multiple microrobots and to estimate and mitigate spatial uncertainty estimation for modular serial link robotic platforms. In this dissertation I describe novel methods to enhance the performance of magnetic microrobots, reduce environmental forces via inexpensive anti-friction coatings, and increase their velocities via novel mechanical amplifiers. Such methods generate swarming motions, with a leader and formation following behavior, and cooperative planar motions compatible with micromanipulation tasks such as grasping. Moreover, I provide a possible application scenario using such cooperative behavior to assemble optical elements.The cooperative grasping behavior is produced by the magnetic field gradient controlled by a modular multi-degree of freedom serial link robot used to position the conical permanent magnet with respect to the robots' workspace. In the course of this research it was necessary to precisely characterize and compensate for the spatial uncertainty of the robot. Spatial uncertainty is an inherent feature of multiple-link robots due to misalignment of joints, link length, resolution of the actuator, the type of joint, the path of motion and the atmosphere of operation. Such uncertainties can be detrimental for robots used in assembly tasks where precision is essential. In order to overcome this fundamental challenge with flexible or modular assembly and packaging systems, I presents a novel precision evaluation and control technique to estimate and track the end-effector position errors in a robotic manipulation system resulting from the kinematic configuration as well as the dynamic parameters for each specific task; thereby, allowing the automation application to compensate for these errors in run-time.

Mobile Microrobotics

Mobile Microrobotics
Author: Metin Sitti
Publisher: MIT Press
Total Pages: 305
Release: 2017-06-16
Genre: Technology & Engineering
ISBN: 0262341018

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The first textbook on micron-scale mobile robotics, introducing the fundamentals of design, analysis, fabrication, and control, and drawing on case studies of existing approaches. Progress in micro- and nano-scale science and technology has created a demand for new microsystems for high-impact applications in healthcare, biotechnology, manufacturing, and mobile sensor networks. The new robotics field of microrobotics has emerged to extend our interactions and explorations to sub-millimeter scales. This is the first textbook on micron-scale mobile robotics, introducing the fundamentals of design, analysis, fabrication, and control, and drawing on case studies of existing approaches. The book covers the scaling laws that can be used to determine the dominant forces and effects at the micron scale; models forces acting on microrobots, including surface forces, friction, and viscous drag; and describes such possible microfabrication techniques as photo-lithography, bulk micromachining, and deep reactive ion etching. It presents on-board and remote sensing methods, noting that remote sensors are currently more feasible; studies possible on-board microactuators; discusses self-propulsion methods that use self-generated local gradients and fields or biological cells in liquid environments; and describes remote microrobot actuation methods for use in limited spaces such as inside the human body. It covers possible on-board powering methods, indispensable in future medical and other applications; locomotion methods for robots on surfaces, in liquids, in air, and on fluid-air interfaces; and the challenges of microrobot localization and control, in particular multi-robot control methods for magnetic microrobots. Finally, the book addresses current and future applications, including noninvasive medical diagnosis and treatment, environmental remediation, and scientific tools.

Untethered Small-Scale Robots for Biomedical Applications

Untethered Small-Scale Robots for Biomedical Applications
Author: Haojian Lu
Publisher: Academic Press
Total Pages: 164
Release: 2023-06-12
Genre: Technology & Engineering
ISBN: 0128221623

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Untethered Small-Scale Robots for Biomedical Applications introduces the principle, design, fabrication and application of small-scale robots for biomedical applications. Robots in the scale of nanometer, micrometer and millimeter are described in detail, along with their impact on the field of biomedical engineering. The selected examples of robots across different scales are of the most essential and innovative designs in a small-scale robot with various application settings for biomechanics characterization, drug delivery and surgical procedure. The representative robots represented operate robustly and safely in complex physiological environments where they have a transformative impact in bioengineering and healthcare. This book will lead the audience to the field of small-scale robots through the description of the physics in the small scale, design and fabrication of small-scale robots, and how these robots may impact the future of biomedical studies and minimally-invasive surgical procedures. Provides a comprehensive review of the current advances in biomedical untethered mobile milli/microrobots Describes the most representative small-scale robots in detail, including design, fabrication, control and function aspects Presents the imminent potential impacts of biomedical microrobots Discusses the existing challenges and emerging concepts associated with designing such a miniaturized robot for operation inside a biological environment for biomedical applications

Collective Behavior of Magnetic Micro/Nanorobots

Collective Behavior of Magnetic Micro/Nanorobots
Author: Qianqian Wang
Publisher: CRC Press
Total Pages: 360
Release: 2024-01-26
Genre: Technology & Engineering
ISBN: 100383065X

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Collective Behavior of Magnetic Micro/Nanorobots: Control, Imaging, and Applications reviews recent advances in the design and construction of magnetic collective micro/nanorobot systems, and promotes the bridging of the gap between their theoretical investigation and practical applications. By summarizing the recent progress in control, imaging, and biomedical applications of collective micro/nanorobots, the authors show the big picture of micro/nanorobotics and the roadmap of collective micro/nanorobots. They then discuss the control, imaging, and biomedical applications of collective micro/nanorobots, respectively, demonstrating the state-of-the-art techniques and ideas for designing systems of collective micro/nanorobots that can help researchers have a better understanding and further stimulate the development of such an exciting field. This book is suitable for scientists, engineers, and students involved in the study of robotics, control, materials, and mechanical/electrical engineering.

Micro-Scale Mobile Robotics

Micro-Scale Mobile Robotics
Author: Eric Diller
Publisher: Now Pub
Total Pages: 130
Release: 2013-09
Genre: Technology & Engineering
ISBN: 9781601987105

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Provides a tutorial on the physical phenomena governing the operation and design of microrobots and a survey of existing approaches to microrobot design and control. It also provides an overview of actuation and control methods commonly used to remotely power these designs, as well as a discussion of possible future research directions.

Microbiorobotics

Microbiorobotics
Author: Minjun Kim
Publisher: William Andrew
Total Pages: 329
Release: 2012-03-08
Genre: Science
ISBN: 145577894X

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Microbiorobotics is a new engineering discipline that inherently involves a multidisciplinary approach (mechanical engineering, cellular biology, mathematical modeling, control systems, synthetic biology, etc). Building robotics system in the micro scale is an engineering task that has resulted in many important applications, ranging from micromanufacturing techniques to cellular manipulation. However, it is also a very challenging engineering task. One of the reasons is because many engineering ideas and principles that are used in larger scales do not scale well to the micro-scale. For example, locomotion principles in a fluid do not function in the same way, and the use of rotational motors is impractical because of the difficulty of building of the required components. Microrobotics is an area that is acknowledged to have massive potential in applications from medicine to manufacturing. This book introduces an inter-disciplinary readership to the toolkit that micro-organisms offer to micro-engineering The design of robots, sensors and actuators faces a range of techology challenges at the micro-scale. This book shows how biological techniques and materials can be used to meet these challenges World-class multi-disciplanry editors and contributors leverage insights from engineering, mathematical modeling and the life sciences – creating a novel toolkit for microrobotics

Electromagnetic Actuation and Sensing in Medical Robotics

Electromagnetic Actuation and Sensing in Medical Robotics
Author: Hongliang Ren
Publisher: Springer
Total Pages: 221
Release: 2017-12-30
Genre: Technology & Engineering
ISBN: 9811060355

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This book highlights electromagnetic actuation (EMA) and sensing systems for a broad range of applications including targeted drug delivery, drug-release-rate control, catheterization, intravitreal needleless injections, wireless magnetic capsule endoscopy, and micromanipulations. It also reviews the state-of-the-art magnetic actuation and sensing technologies with remotely controlled targets used in biomedicine.

Field-Driven Micro and Nanorobots for Biology and Medicine

Field-Driven Micro and Nanorobots for Biology and Medicine
Author: Yu Sun
Publisher: Springer Nature
Total Pages: 422
Release: 2021-11-25
Genre: Technology & Engineering
ISBN: 3030801977

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This book describes the substantial progress recently made in the development of micro and nanorobotic systems, utilizing magnetic, optical, acoustic, electrical, and other actuation fields. It covers several areas of micro and nanorobotics including robotics, materials science, and biomedical engineering. Field-Driven Micro and Nanorobots for Biology and Medicine provides readers with fundamental physics at the micro and nano scales, state-of-the-art technical advances in field-driven micro and nanorobots, and applications in biological and biomedical disciplines.