Tritium processing operations have been performed at the Savannah River Site (SRS) since 1955. It was determined in the early 1980's that new tritium facilities were required in order to meet increasingly stringent safety and environmental requirements while maintaining productivity. Construction of a new tritium handling facility, the Replacement Tritium Facility (RTF), began in 1987. This new facility incorporates the latest technology and design philosophy to mitigate accident consequences, enhance operational safety, minimize tritium losses to the environment, and ensure material safeguards and security. The RTF is currently completing startup operations. This report details key features addressed during the design and startup of this facility.