Inside the Hot Zone is an insider’s account of one of the most dangerous workplaces on earth: the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) in Fort Detrick, Maryland. Retired U.S. Army Col. Mark G. Kortepeter, a leading biodefense expert, recounts his journey from the lecture hall to the role of department chief, to the battlefield, to the Biosafety Level-4 maximum containment lab, and finally, to the corner office. During Kortepeter’s seven and a half years in leadership at USAMRIID, the United States experienced some of the most serious threats in modern germ warfare, including the specter of biological weapons during the Iraq War, the anthrax letters sent after 9/11, and a little-known crisis involving a presumed botulism attack on the president of the United States. Inside the Hot Zone is a shocking, frightening eye-opener as Kortepeter describes in gripping detail how he and his USAMRIID colleagues navigated threats related to anthrax, botulism, smallpox, Lassa, and Ebola. Kortepeter crafts a rich and riveting narrative as he wrestles with life-and-death decisions managing biological weapon exposures. The stories are real, but they could just as easily serve as plotlines in popular fiction or Hollywood thrillers. He gives the reader a seat at the table as each crisis unfolds, with an unvarnished and personal perspective on the dangers, the drama, the fear, the frustrations, the irony, and the uncertainty he encountered as a physician in the role of “Biodefender.”