Clinical Pharmacology: Current Topics and Case Studies

Clinical Pharmacology: Current Topics and Case Studies
Author: Markus Müller
Publisher: Springer
Total Pages: 398
Release: 2016-03-15
Genre: Medical
ISBN: 3319273477

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This revised and extended second edition focuses on current and emerging topics in drug development, their molecular mechanisms of action as well as regulatory issues. In addition, in-depth insights into clinical drug research and trial methodology are presented on the basis of concrete case studies. This updated book makes a valuable contribution to the field of Clinical Pharmacology and serves as a must-have guide for professors, researchers and advanced students from academia and pharmaceutical industry.

Clinical Pharmacology: Current Topics and Case Studies

Clinical Pharmacology: Current Topics and Case Studies
Author: Markus Müller
Publisher: Springer Science & Business Media
Total Pages: 438
Release: 2011-02-04
Genre: Medical
ISBN: 3709101441

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Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.

Clinical Pharmacology - E-Book

Clinical Pharmacology - E-Book
Author: Morris J. Brown
Publisher: Elsevier Health Sciences
Total Pages: 688
Release: 2018-03-22
Genre: Medical
ISBN: 070207330X

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‘The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold’s Pilgrimage, ‘I awoke one morning and found myself famous.’ The twelfth edition of this long-established textbook of clinical pharmacology (first published in 1960) continues its fine tradition of balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy. Coverage of all major therapeutic topics by body system. Introductory sections give brief chapter synopses. Case studies where relevant. Covers the needs of the developing world with a focus on practical prescribing and health technology assessment. Definition, tips, brief explanation boxes throughout. Interesting histories, etymologies and provenances of terms throughout. Entertaining footnotes throughout. ‘The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold’s Pilgrimage, ‘I awoke one morning and found myself famous.’ Fully updated throughout. New co-editor: Fraz Mir, Addenbrooke’s Hospital and Department of Medicine, University of Cambridge, Royal College of Physicians Associate International Director for South Asia. Now with free e-book on StudentConsult.

Topics in Clinical Pharmacology and Therapeutics

Topics in Clinical Pharmacology and Therapeutics
Author: Robert F. Maronde
Publisher: Springer Science & Business Media
Total Pages: 528
Release: 2012-12-06
Genre: Medical
ISBN: 1461248647

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Dr. Maronde has performed a major service in bringing together a superb array of scholars and clinicians to discuss not only the basic principles in therapeutics and clinical pharmacology but also the application of those principles to a wide range of clinical problems. Inclusion of chapters on adverse drug reactions, drug overdose, nonmedical prescription drug use, physician prescribing patterns, and the pharmaceutical industry makes this a particularly valuable book for clinicians. It is increasingly important that clinicians be well grounded in the principles of pharmacodynamics and pharmacokinetics because more and more of our patients are aging and cannot be treated as young or middle-aged adults. Elderly patients are liable to either drug overdose or underdose if traditional dosage formulas are followed because of changes in drug metabolism, drug distribution within the body, drug excretion, or changes in receptor site sensitivity. Because the elderly often present with mUltiple chronic diseases and require a variety of medications, they are more prone to medication errors, drug-drug interactions, and adverse drug reactions. The inclusion of three excellent chapters relating to drug-drug interactions, adverse drug reactions, and drug overdose is most welcome and is a valuable addition to this outstanding text on therapeutics and clinical pharmacology. Adverse drug reactions present a potentially serious problem for any patient for whom drugs are prescribed and particularly for those who must take multiple prescriptions.

Clinical Pharmacology in Athletic Training

Clinical Pharmacology in Athletic Training
Author: Michelle Cleary
Publisher: Human Kinetics
Total Pages: 371
Release: 2021-10-12
Genre: Medical
ISBN: 1492594199

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Athletic trainers have a responsibility to provide high-quality pharmaceutical care while meeting both legal and ethical requirements. Clinical Pharmacology in Athletic Training empowers athletic trainers with a functional understanding of pharmacology that enables them to formulate a treatment plan intended to mitigate disease and improve the overall health of their patients. This text incorporates the most up-to-date content from the 2020 Commission on Accreditation of Athletic Training Education (CAATE) standards, and it emphasizes interprofessional practice to enable future and current athletic trainers to collaborate with other health professionals in a manner that optimizes the quality of care. Clinical Pharmacology in Athletic Training begins by addressing drug legislation and the legal aspects of the athletic trainer’s role in sport medication. The text provides an overview of pharmacokinetics and pharmacodynamics with an emphasis on concepts relevant to clinical practice. Students are introduced to the generic and brand names, general classifications, and appropriate administration of drugs and are guided toward appropriate online reference materials. Part II of this text describes common medications for pain, inflammation, and infections. Part III includes medications for specific conditions, including respiratory, cardiovascular, gastrointestinal, neurological, gynecological, and mental health conditions. The text also includes current information on opioid analgesics, cannabis, and cannabinoid-based medications. Clinical Pharmacology in Athletic Training teaches students to administer appropriate pharmacological agents for the management of the patient’s condition. The information includes indications, contraindications, dosing, interactions, and adverse reactions. The following features are included to aid in the learning process: Chapter objectives set the stage for the main topics covered in the chapter. Key terms are boldfaced to indicate terms of special importance, and a glossary of definitions is included at the back of the book. Red Flag sidebars highlight warnings and precautions for certain medications or medicolegal issues. Evidence in Pharmacology sidebars highlight recent research regarding medications. Clinical Application sidebars present real-life stories from the field of athletic training. Case studies highlight specific therapeutic medication applications and are accompanied by questions that prompt readers to think critically about the issues presented. Quick reference drug tables describe medication types, generic and brand names, pronunciations, common indications, and other special considerations for the athletic trainer. Over the past decade, there has been an increased emphasis on pharmacology in athletic training. Clinical Pharmacology in Athletic Training will equip students with appropriate skills and competencies, prepare them to meet patient needs, and enable them to work in interprofessional teams.

Case Studies in Clinical Pharmacology

Case Studies in Clinical Pharmacology
Author: Marcia Moeller Grant
Publisher:
Total Pages: 169
Release: 1977
Genre: Chemotherapy
ISBN: 9780803642805

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Pharmacokinetics and Pharmacodynamics of Biotech Drugs

Pharmacokinetics and Pharmacodynamics of Biotech Drugs
Author: Bernd Meibohm
Publisher: John Wiley & Sons
Total Pages: 426
Release: 2006-12-13
Genre: Science
ISBN: 3527609520

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This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim. The result is vital reading for all pharmaceutical researchers.

100 Cases in Clinical Pharmacology, Therapeutics and Prescribing

100 Cases in Clinical Pharmacology, Therapeutics and Prescribing
Author: Kerry Layne
Publisher: CRC Press
Total Pages: 249
Release: 2020-01-29
Genre: Medical
ISBN: 0429624972

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100 Cases in Clinical Pharmacology, Therapeutics and Prescribing explores scenarios commonly seen by medical students and junior doctors in the ward, emergency department, outpatient clinic or in general practice in which an understanding of pharmacology and sound prescribing practice is central to successful clinical management and safe patient care. A succinct summary of the patient’s history, examination and any initial investigations is followed by questions on the diagnosis and management of the case. The answer includes a detailed discussion on each topic, providing practical advice on how to deal with the challenges that occur when prescribing, including planning, drug calculations, prescription review and adverse drug reactions. The book will be invaluable during clinical placements and is an ideal companion during preparation for the Prescribing Safety Assessment examination. Making speedy and appropriate clinical decisions, and choosing the best course of action to take as a result, is one of the most important and challenging parts of training to become a doctor. These true-to-life cases will teach students and junior doctors to prescribe appropriately, and to hone their diagnostic and management skills.

Pharmacology Case Studies

Pharmacology Case Studies
Author: Al Rundio
Publisher:
Total Pages:
Release: 2015-11-15
Genre:
ISBN: 9781935213680

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Principles of Clinical Pharmacology

Principles of Clinical Pharmacology
Author: Shiew-Mei Huang
Publisher: Academic Press
Total Pages: 649
Release: 2012-09-18
Genre: Medical
ISBN: 0123854725

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Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science. The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions Offers an expanded regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III