The book takes a cursory look at the drivers and the directions of Africa’s developmental drive as a largely developing continent within the frameworks of the ever-dynamic global space, putting into perspective inherent challenges and opportunities of the 21st Century, and thereafter. Being the continent with most youthful population, Africa appears to still lack in requisite innovative interventions to transmute such demographic dividend into economic opportunities for the benefits of the larger population. Instead, there has been increasing trend in South-North migrations among both skilled and unskilled Africans across all age groups. Besides, impacts of climate change on the continent have also implied unstructured migratory trend within and beyond the bounds of the continent. Africa has continued to play a feeble role in various United Nations (UN)-enabled ‘Conference of Parties’ (COP) negotiations, such as the COP-26 in Glasgow, Scotland (2021). The management of recent Covid-19 epidemic across the world has presented a clear pointer to Africa that except development is internally-driven, no one is ready to exogenously drive sustainable good life for others. Ostensible ‘vaccine nationalism’ that has dotted the production and availability of various Covid-19 vaccine brands, which has ultimately left Africa as the ‘begging continent’ one more time calls for in-depth interrogation in contextualizing what the place of Africa has been, is and to be within the global interactive mode.