Classic and Pleiotropic Actions of Vitamin D

Classic and Pleiotropic Actions of Vitamin D
Author: Pawel Pludowski
Publisher: Frontiers Media SA
Total Pages: 169
Release: 2019-09-24
Genre:
ISBN: 2889630080
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The vitamin D is widely advertised as a solution for a large spectrum of diseases and health issues. Growing number of pharmaceuticals and supplements containing vitamin D, increasing availability of them in pharmacies, stores, online distribution and, sometimes, an intrusive commercial publicity campaigns have raised great interest, and have triggered reasonable controversies and fears. The self-administration of high doses of vitamin D has also appeared major concern in society. There is an increasing number of dilemmas regarding side effects including nephrocalcinosis, urinary stone disease, drug interactions and other adversity. On the other hand, it is recognized that vitamin D deficiency is a global health problem with potential negative consequences on health, welfare and morbidity during growth and adulthood, and therefore influencing health care services worldwide. According to current published reports, the vitamin D deficiency is regarded a significant risk factor for several civilization diseases including cancer, cardiovascular diseases, hypertension, autoimmune and metabolic disorders, infectious diseases and many other chronic conditions. Thus, it is essential to discuss vividly, and share scientific reports and evidence demonstrating both the safety issues and the significance of vitamin D for health of children, adolescents, middle-aged men and women, professionally active individuals, and seniors. This eBook is a collection of articles presented at the 3rd International Conference “Vitamin D - Minimum, Maximum, Optimum” (EVIDAS 2017) held in Warsaw (Poland) on September 22–23, 2017. EVIDAS (European Vitamin D Association) is a scientific society focused on vitamin D and its meaning for human health.

Vitamin D

Vitamin D
Author: Martin Hewison
Publisher: Academic Press
Total Pages: 1268
Release: 2017-12-14
Genre: Science
ISBN: 012809964X
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Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease. This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles Chapter authors include the most prominent and well-published names in the field Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis and vitamin D deficiency Presents a clinical focus on disorders, analogs, cancer, immunity, inflammation, disease and therapeutic applications

Phosphate Metabolism

Phosphate Metabolism
Author: Shaul Massry
Publisher: Springer Science & Business Media
Total Pages: 611
Release: 2013-11-21
Genre: Medical
ISBN: 1461342171
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We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.

Vitamin D

Vitamin D
Author: Michael F. Holick
Publisher: Springer Science & Business Media
Total Pages: 456
Release: 2013-03-09
Genre: Medical
ISBN: 1475728611
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The Nutrition and Health series of books has as an overriding mission to provide health professionals with texts that are considered essential because each includes: a synthesis of the state of the science; timely, in-depth reviews by the leading researchers in their respective fields; extensive, up-to-date fully annotated reference lists; a detailed index; relevant tables and figures; identification of paradigm shifts and the consequences; of information between chapters, but targeted, inter-chapter refer virtually no overlap rals, suggestions of areas for future research; and balanced, data-driven answers to patient questions that are based on the totality of evidence rather than the findings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter as well as in the choice of chapter authors. The international perspective, especially with regard to public health initiatives, is emphasized where appropriate. The editors, whose training is both research and practice oriented, have the opportunity to develop a primary objective for their book, define the scope and focus, and then invite the leading authori ties from around the world to be part of their initiative. The authors are encouraged to provide an overview of the field, discuss their own research, and relate the research de findings to potential human health consequences.

Vitamin D

Vitamin D
Author: Martin Hewison
Publisher: Academic Press
Total Pages: 1182
Release: 2017-12-14
Genre: Science
ISBN: 0128099666
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Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications

Vitamin D

Vitamin D
Author: Anthony Norman
Publisher: Elsevier
Total Pages: 509
Release: 2012-12-02
Genre: Medical
ISBN: 0323141439
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Vitamin D: The Calcium Homeostatic Steroid Hormone provides a continuing coordinated group of edited critiques of the dynamic state of the science and art of nutrition. The most recent basic advances will be reviewed within the broad framework of the scientific knowledge of food and nutrition, including its application to man, individually and societally. The volumes, authored singly or by invited contributors, will appeal to serious scholars concerned with pure or applied nutrition. This volume comprises 13 chapters, with the first discussing the progress of vitamin D-cholecalciferol from vitamin to steroid hormone. Succeeding chapters then discuss the biological and chemical assay of vitamin D, its metabolites, and analogs; metabolism of vitamin D; and the tissue and subcellular localization of vitamin D and its metabolites. Other chapters cover binding proteins and receptors for vitamin D and its metabolites; interrelationships between vitamin D and other hormones; intestinal effects of vitamin D; vitamin D actions in the kidney; vitamin D actions on bone; and vitamin D and its clinical relationships. This book will be of interest to practitioners in the fields of chemistry, nutrition, and medicine.

Vitamin D

Vitamin D
Author: David Feldman
Publisher: Elsevier
Total Pages: 1970
Release: 2005-01-25
Genre: Medical
ISBN: 0080543642
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Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research. *Most comprehensive, up-to-date two-volume set on Vitamin D *New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more *Further sections on emerging uses for treatments of auto-immune diseases and diabetes *Over 600 illustrations and figures available on CD

Vitamin D

Vitamin D
Author: H.F. DeLuca
Publisher: Springer
Total Pages: 0
Release: 2011-12-13
Genre: Medical
ISBN: 9783642813085
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Because diseases of the bone are often less acute and less lifethreatening than dis eases of the circulatory system, gastrointestinal tract, kidney, liver, and the nervous system, they have received a disproportionately smaller amount of attention in the medical world. With the average increasing life span of man as a result of improve ments in modern medicine, espe~ially in the pediatric field, the seriousness of many metabolic bone diseases has indeed become more obvious. In addition, other improvements in medicine, such as hemodialysis for the preservation of renal failure patients, have permitted the development of other consequences of diseased kidneys, one of which is the appearance of renal osteodystrophy. Finally, the appearance of several genetic disorders in the area of metabolic bone disease has been underscored by the solution of other pediatric diseas~s of much more serious consequences. These emerging problems all suggest that much remains to be learned concerning the sys temic control of bone, both as a structural organ and as a reservoir for the important elements of calcium and phosphorus so essential for the support of life in complex multicellular organisms of which man is the most important. As will be demonstrated in the historical portion of this manuscript, the existence of the three most important humoral factors regulating bone metabolism and func tion are now known.

The Essential Guide to Vitamin D

The Essential Guide to Vitamin D
Author: Jana Andelov
Publisher:
Total Pages:
Release: 2020-02-26
Genre:
ISBN: 9781536166002
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The guide first discusses vitamin D receptor, a member of the superfamily of nuclear steroid/thyroid hormone receptors that can be found in both the cytoplasm and nucleus. It acts mainly as a ligand-dependent DNA-binding transcriptional factor mediating the actions of the biological active form of vitamin D (VD), the metabolite 1α,25[OH]2D3. Vitamin D has a complex role in the human body. Beside the classical effects in bone mineralization, a significant amount of data regarding the role of this vitamin in cell differentiation, defense mechanism, allergy, inflammation, metabolism and hormonal regulation continue to accumulate. As such, the relevance of these effects for lung disorders is under investigation. Vitamin D is a hormone with pleiotropic effects; it controls calcium homeostasis, immune response, and hemodynamic wall stress. In the last decade, numerous studies have focused on the role of vitamin D levels in cardiovascular disease. In particular, it has been shown that insufficient Vitamin D levels are frequently observed among patients with cardiovascular disease. Additionally, calcitriol, which is also called 1, 25-dihydroxy vitamin D3, is involved in several physiological processes maintaining balanced bone turnover and a healthy bone microenvironment. The beneficial effects of vitamin D on bone biomechanical features are not exclusively attributable to the reduction in non-mineralized bone matrix, but to the osteocyte number and their connectivity, too. Studies have reported that Vitamin D is essential for recovery of hospitalized patients as they are at increased risk of developing/worsening vitamin D deficiency due to lack of availability of sources of the vitamin. Various cognitive disorders have also been associated with hypovitaminosis D. Vitamin D has also been proposed as a risk-modifying factor for many chronic diseases, including multiple sclerosis, schizophrenia, cognitive issues, hypertension, heart disease, diabetes, cancer, psoriasis, and other autoimmune diseases. Vitamin D deficiency is the main cause of osteoporosis and osteomalacia in adults and rickets in children. The low serum of this vitamin is common in patients suffering from cardiovascular, autoimmune, cancer, psoriasis, depression and atherosclerosis disorder. The highly sensitive nature of vitamin D to environmental factors including light, heat, and oxygen, as well as hydrophobicity and acid labile nature, are the major drawbacks that need to be addressed for development of an efficient formulation for vitamin D.

Feldman and Pike’s Vitamin D

Feldman and Pike’s Vitamin D
Author: Martin Hewison
Publisher: Elsevier
Total Pages: 1232
Release: 2023-10-28
Genre: Reference
ISBN: 0323913903
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Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field. • A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D • Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of vitamin D, as opposed to searching through thousands of journal articles • Chapters written by the most prominent and well-published names in the field