Catalyzing Inquiry at the Interface of Computing and Biology

Catalyzing Inquiry at the Interface of Computing and Biology
Author: National Research Council
Publisher: National Academies Press
Total Pages: 469
Release: 2006-01-01
Genre: Science
ISBN: 030909612X

Download Catalyzing Inquiry at the Interface of Computing and Biology Book in PDF, Epub and Kindle

Advances in computer science and technology and in biology over the last several years have opened up the possibility for computing to help answer fundamental questions in biology and for biology to help with new approaches to computing. Making the most of the research opportunities at the interface of computing and biology requires the active participation of people from both fields. While past attempts have been made in this direction, circumstances today appear to be much more favorable for progress. To help take advantage of these opportunities, this study was requested of the NRC by the National Science Foundation, the Department of Defense, the National Institutes of Health, and the Department of Energy. The report provides the basis for establishing cross-disciplinary collaboration between biology and computing including an analysis of potential impediments and strategies for overcoming them. The report also presents a wealth of examples that should encourage students in the biological sciences to look for ways to enable them to be more effective users of computing in their studies.

Catalyzing Inquiry at the Interface of Computing and Biology

Catalyzing Inquiry at the Interface of Computing and Biology
Author: John C. Wooley and Herbert S. Lin
Publisher:
Total Pages: 443
Release: 2005
Genre: Bioinformatics
ISBN:

Download Catalyzing Inquiry at the Interface of Computing and Biology Book in PDF, Epub and Kindle

Advances in computer science and technology and in biology over the last several years have opened up the possibility for computing to help answer fundamental questions in biology and for biology to help with new approaches to computing. Making the most of the research opportunities at the interface of computing and biology requires the active participation of people from both fields. While past attempts have been made in this direction, circumstances today appear to be much more favorable for progress. To help take advantage of these opportunities, this study was requested of the NRC by the National Science Foundation, the Department of Defense, the National Institutes of Health, and the Department of Energy. The report provides the basis for establishing cross-disciplinary collaboration between biology and computing including an analysis of potential impediments and strategies for overcoming them. The report also presents a wealth of examples that should encourage students in the biological sciences to look for ways to enable them to be more effective users of computing in their studies.

Catalyzing Inquiry at the Interface of Computing and Biology

Catalyzing Inquiry at the Interface of Computing and Biology
Author:
Publisher:
Total Pages:
Release: 2005
Genre:
ISBN:

Download Catalyzing Inquiry at the Interface of Computing and Biology Book in PDF, Epub and Kindle

This study is the first comprehensive NRC study that suggests a high-level intellectual structure for Federal agencies for supporting work at the biology/computing interface. The report seeks to establish the intellectual legitimacy of a fundamentally cross-disciplinary collaboration between biologists and computer scientists. That is, while some universities are increasingly favorable to research at the intersection, life science researchers at other universities are strongly impeded in their efforts to collaborate. This report addresses these impediments and describes proven strategies for overcoming them. An important feature of the report is the use of well-documented examples that describe clearly to individuals not trained in computer science the value and usage of computing across the biological sciences, from genes and proteins to networks and pathways, from organelles to cells, and from individual organisms to populations and ecosystems. It is hoped that these examples will be useful to students in the life sciences to motivate (continued) study in computer science that will enable them to be more facile users of computing in their future biological studies.

Positioning Synthetic Biology to Meet the Challenges of the 21st Century

Positioning Synthetic Biology to Meet the Challenges of the 21st Century
Author: National Research Council
Publisher: National Academies Press
Total Pages: 81
Release: 2013-08-05
Genre: Science
ISBN: 0309225868

Download Positioning Synthetic Biology to Meet the Challenges of the 21st Century Book in PDF, Epub and Kindle

Synthetic biology-unlike any research discipline that precedes it-has the potential to bypass the less predictable process of evolution to usher in a new and dynamic way of working with living systems. Ultimately, synthetic biologists hope to design and build engineered biological systems with capabilities that do not exist in natural systems-capabilities that may ultimately be used for applications in manufacturing, food production, and global health. Importantly, synthetic biology represents an area of science and engineering that raises technical, ethical, regulatory, security, biosafety, intellectual property, and other issues that will be resolved differently in different parts of the world. As a better understanding of the global synthetic biology landscape could lead to tremendous benefits, six academies-the United Kingdom's Royal Society and Royal Academy of Engineering, the United States' National Academy of Sciences and National Academy of Engineering, and the Chinese Academy of Science and Chinese Academy of Engineering-organized a series of international symposia on the scientific, technical, and policy issues associated with synthetic biology. Positioning Synthetic Biology to Meet the Challenges of the 21st Century summarizes the symposia proceedings.

Frontiers of Engineering

Frontiers of Engineering
Author: National Academy of Engineering
Publisher: National Academies Press
Total Pages: 133
Release: 2001-03-07
Genre: Technology & Engineering
ISBN: 0309073197

Download Frontiers of Engineering Book in PDF, Epub and Kindle

In 1995 the National Academy of Engineering (NAE) initiated the Frontiers of Engineering Symposium program, which every year brings together 100 of the nation's future engineering leaders to learn about cutting-edge research and technical work in different engineering fields. On September 14-16, 2000, the National Academy of Engineering held its sixth Frontiers of Engineering Symposium at the Academies' Beckman Center in Irvine, California. Symposium speakers were asked to prepare extended summaries of their presentations, and it is those papers that are contained here. The intent of this book, and of the five that precede it in the series, is to describe the content and underpinning philosophy of this unique meeting and to highlight some of the exciting developments in engineering today.

Calculating the Secrets of Life

Calculating the Secrets of Life
Author: National Research Council
Publisher: National Academies Press
Total Pages: 300
Release: 1995-04-06
Genre: Science
ISBN: 0309048869

Download Calculating the Secrets of Life Book in PDF, Epub and Kindle

As researchers have pursued biology's secrets to the molecular level, mathematical and computer sciences have played an increasingly important roleâ€"in genome mapping, population genetics, and even the controversial search for "Eve," hypothetical mother of the human race. In this first-ever survey of the partnership between the two fields, leading experts look at how mathematical research and methods have made possible important discoveries in biology. The volume explores how differential geometry, topology, and differential mechanics have allowed researchers to "wind" and "unwind" DNA's double helix to understand the phenomenon of supercoiling. It explains how mathematical tools are revealing the workings of enzymes and proteins. And it describes how mathematicians are detecting echoes from the origin of life by applying stochastic and statistical theory to the study of DNA sequences. This informative and motivational book will be of interest to researchers, research administrators, and educators and students in mathematics, computer sciences, and biology.

Computational Technology for Effective Health Care

Computational Technology for Effective Health Care
Author: National Research Council
Publisher: National Academies Press
Total Pages: 121
Release: 2009-02-24
Genre: Computers
ISBN: 0309155843

Download Computational Technology for Effective Health Care Book in PDF, Epub and Kindle

Despite a strong commitment to delivering quality health care, persistent problems involving medical errors and ineffective treatment continue to plague the industry. Many of these problems are the consequence of poor information and technology (IT) capabilities, and most importantly, the lack cognitive IT support. Clinicians spend a great deal of time sifting through large amounts of raw data, when, ideally, IT systems would place raw data into context with current medical knowledge to provide clinicians with computer models that depict the health status of the patient. Computational Technology for Effective Health Care advocates re-balancing the portfolio of investments in health care IT to place a greater emphasis on providing cognitive support for health care providers, patients, and family caregivers; observing proven principles for success in designing and implementing IT; and accelerating research related to health care in the computer and social sciences and in health/biomedical informatics. Health care professionals, patient safety advocates, as well as IT specialists and engineers, will find this book a useful tool in preparation for crossing the health care IT chasm.

Science at the Frontier

Science at the Frontier
Author: National Academy of Sciences
Publisher: National Academies Press
Total Pages: 286
Release: 1992-02-01
Genre: Science
ISBN: 0309045924

Download Science at the Frontier Book in PDF, Epub and Kindle

Science at the Frontier takes you on a journey through the minds of some of the nation's leading young scientists as they explore the most exciting areas of discovery today. Based on the second Frontiers of Science symposium sponsored by the National Academy of Sciences, this book describes recent accomplishments and new directions in ten basic fields, represented by outstanding scientists convening to discuss their research. It captures the excitement and personal quality of these exchanges, sometimes pointing to surprising connections spanning the boundaries of traditional disciplines, while providing a context for the reader that explains the basic scientific framework for the fields under discussion. The volume explores: New modifications to scientific theory as geologists probe deep inside the earth and astrophysicists reach to the limits of the observable universe for answers to some of nature's most fundamental and vexing questions. The influence of research in smog formation on the public debate about how to effectively control air pollution. The increasing use of computer modeling in science, from describing the evolution of cellular automata to revealing the workings of the human brain via neural networks. The rise of dynamical systems (the study of chaotic behavior in nature) to a full-fledged science. The search to understand the regulation of gene activity and the many biological problems-such as the onset of cancer-to which it applies. Recent progress in the quest to transform what we know about photosynthesis into functional, efficient systems to tap the sun's energy. Current developments in magnetic resonance imaging and its promise for new breakthroughs in medical diagnosis. Throughout this work the reader is witness to scientific discovery and debate centered on such common concerns as the dramatic and transforming effect of computers on scientists' thinking and research; the development of more cross-disciplinary perspectives; and the very nature of the scientific enterprise itself-what it is to be part of it, and its significance for society. Science at the Frontier is must reading for informed lay readers, scientists interested in fields other than their own, and science students considering a future specialization.

Next Steps for Functional Genomics

Next Steps for Functional Genomics
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 201
Release: 2020-12-18
Genre: Science
ISBN: 0309676738

Download Next Steps for Functional Genomics Book in PDF, Epub and Kindle

One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.

Mathematical Challenges from Theoretical/Computational Chemistry

Mathematical Challenges from Theoretical/Computational Chemistry
Author: National Research Council
Publisher: National Academies Press
Total Pages: 143
Release: 1995-03-29
Genre: Mathematics
ISBN: 030917662X

Download Mathematical Challenges from Theoretical/Computational Chemistry Book in PDF, Epub and Kindle

Computational methods are rapidly becoming major tools of theoretical, pharmaceutical, materials, and biological chemists. Accordingly, the mathematical models and numerical analysis that underlie these methods have an increasingly important and direct role to play in the progress of many areas of chemistry. This book explores the research interface between computational chemistry and the mathematical sciences. In language that is aimed at non-specialists, it documents some prominent examples of past successful cross-fertilizations between the fields and explores the mathematical research opportunities in a broad cross-section of chemical research frontiers. It also discusses cultural differences between the two fields and makes recommendations for overcoming those differences and generally promoting this interdisciplinary work.