Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine

Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine
Author: Justin Brown
Publisher: Academic Press
Total Pages: 254
Release: 2016-11-03
Genre: Technology & Engineering
ISBN: 0128033991
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Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations. The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications. In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics. Presents a self-contained work for the field of musculoskeletal tissue engineering and regenerative medicine Focuses on how materials of structures can be designed to be resistant while promoting viable grafts Contains major tissue types that are covered with a strategy for each material and structure

Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine

Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine
Author: J. Miguel Oliveira
Publisher: Elsevier
Total Pages: 556
Release: 2023-11-28
Genre: Science
ISBN: 0323972624
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Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined. Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health. Presents the fundamentals of the complex interplay of cells with biomaterials in musculoskeletal tissue engineering Includes coverage of stem cells and cell-based therapies, in vitro and in vivo models, nanotechnology, bioprinting, computational modeling, regulatory and clinical translation, and much more Written by global leaders in the field

Musculoskeletal Tissue Engineering

Musculoskeletal Tissue Engineering
Author: Yupeng Chen
Publisher: Elsevier
Total Pages: 385
Release: 2021-11-04
Genre: Technology & Engineering
ISBN: 0128242108
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Musculoskeletal Tissue Engineering introduces the fundamental concepts and translational applications of musculoskeletal tissue engineering, in combination with emerging technologies and materials. Sections discuss Tissues and Technologies, covering a range of musculoskeletal tissues, including bone, cartilage, ligament and more. Each chapter in this section details core tissue engineering principles specific to each tissue type. Next, a Technologies section looks at the range of biomaterials used in musculoskeletal tissue engineering, focusing on biocompatibility of materials and interactions at the material-tissue interface. Other chapters cover nanotechnology, 3D printing, gene therapy, tissue chips, and more. This book offers an advanced reference text for researchers in biomedical engineering, materials science and regenerative medicine. Details various materials and cutting-edge technologies for musculoskeletal tissue engineering Covers a range of musculoskeletal tissues, including bone, cartilage, ligament, tendon, meniscus, and more Provides a balance between basic concepts and translational applications for a broad audience

Developmental Biology and Musculoskeletal Tissue Engineering

Developmental Biology and Musculoskeletal Tissue Engineering
Author: Martin J. Stoddart
Publisher: Academic Press
Total Pages: 272
Release: 2018-04-24
Genre: Medical
ISBN: 0128115386
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Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair

Nanoengineering in Musculoskeletal Regeneration

Nanoengineering in Musculoskeletal Regeneration
Author: Mehdi Razavi
Publisher: Academic Press
Total Pages: 290
Release: 2020-05-09
Genre: Science
ISBN: 0128202637
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Nanoengineering in Musculoskeletal Regeneration provides the reader an updated summary of the therapeutic pipeline—from biomedical discovery to clinical implementation—aimed at improving treatments for patients with conditions of the muscles, tendons, cartilage, meniscus, and bone. Regenerative medicine focuses on using stem cell biology to advance medical therapies for devastating disorders. This text presents novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in musculoskeletal regeneration. Content includes basic, translational, and clinical research addressing musculoskeletal repair and regeneration for the treatment of diseases and injuries of the skeleton and its associated tissues. Musculoskeletal degeneration and complications from injuries have become more prevalent as people live longer and increasingly participate in rigorous athletic and recreational activities. Additionally, defects in skeletal tissues may immobilize people and cause inflammation and pain. Musculoskeletal regeneration research provides solutions to repair, restore, or replace skeletal elements and associated tissues that are affected by acute injury, chronic degeneration, genetic dysfunction, and cancer-related defects. The goal of musculoskeletal regeneration medicine research is to improve quality of life and outcomes for people with musculoskeletal injury or degradation. Provides broad coverage in all research areas focused on the applications of nanotechnology in musculoskeletal regeneration Offers useful guidance for physician-scientists with expertise in orthopedics, regenerative medicine, bioengineering, biomaterials, nanoengineering, stem cell biology, and chemistry Serves as a practical reference for many disciplines, including bioengineering, biomaterials, tissue engineering, regenerative medicine, musculoskeletal regenerative medicine, and nanomedicine

Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine

Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine
Author: Gilson Khang
Publisher: CRC Press
Total Pages: 1480
Release: 2017-06-26
Genre: Medical
ISBN: 9814745138
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Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs—regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine.

Regenerative Engineering of Musculoskeletal Tissues and Interfaces

Regenerative Engineering of Musculoskeletal Tissues and Interfaces
Author: Syam Nukavarapu
Publisher: Woodhead Publishing
Total Pages: 463
Release: 2015-04-24
Genre: Science
ISBN: 1782423141
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Repair and regeneration of musculoskeletal tissues is generating substantial interest within the biomedical community. Consequently, these are the most researched tissues from the regeneration point of view. Regenerative Engineering of Musculoskeletal Tissues and Interfaces presents information on the fundamentals, progress and recent developments related to the repair and regeneration of musculoskeletal tissues and interfaces. This comprehensive review looks at individual tissues as well as tissue interfaces. Early chapters cover various fundamentals of biomaterials and scaffolds, types of cells, growth factors, and mechanical forces, moving on to discuss tissue-engineering strategies for bone, tendon, ligament, cartilage, meniscus, and muscle, as well as progress and advances in tissue vascularization and nerve innervation of the individual tissues. Final chapters present information on musculoskeletal tissue interfaces. Comprehensive review of the repair and regeneration of musculoskeletal individual tissues and tissue interfaces Presents recent developments, fundamentals and progress in the field of engineering tissues Reviews progress and advances in tissue vascularization and innervation

CONTROLLING STEM CELL FATE VIA HIGHLY ORGANIZED 2.5-DIMENSIONAL BIO-INSTRUCTIVE FIBROUS SCAFFOLDS.

CONTROLLING STEM CELL FATE VIA HIGHLY ORGANIZED 2.5-DIMENSIONAL BIO-INSTRUCTIVE FIBROUS SCAFFOLDS.
Author: Merve Buluk
Publisher:
Total Pages:
Release: 2019
Genre:
ISBN:
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Approximately 3 million procedures are performed due to musculoskeletal tissue injuries in the United States each year. This leads to an increased financial pressure in healthcare and a loss in patient work days [1]. Since musculoskeletal tissues are essentially bridging two dissimilar tissues, it is crucial to address the varied tissue types and functions as well as the microenvironment. Current replacement strategies in musculoskeletal tissue regeneration and repair often fail due to unappreciation of this variety. Hence, the lack of vascularization, nutrition and waste transport, and cell types can lead to failure in the scaffolds leading to further financial burden and loss in patient work days, as well as further physical pain to the patient. A combination of physical, biological, and chemical cues is needed to create the unique structural transitions and regenerative mechanisms that native tissue interfaces provide [2].An approach that would benefit the goal of regenerating and repairing the musculoskeletal tissues includes the manufacture of a native-like microenvironment incorporated with bio-instructive biomedical material scaffolds that would control stem cell behaviors. For this purpose, materials and structural cues are great tools to use. In this study, it is hoped that using structurally organized nanofibers of biomedical materials, we can control stem cell behaviors, and this will lead to increased levels of certain miRNAs -that are osteogenesis markers- resulting in changes in stem cell fate. We also seek to demonstrate relative gene expression differences of the cells seeded on scaffolds with different nanofiber orientations.

Bio-Inspired Regenerative Medicine

Bio-Inspired Regenerative Medicine
Author: Anna Tampieri
Publisher: CRC Press
Total Pages: 404
Release: 2016-03-30
Genre: Medical
ISBN: 9814669156
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This book presents a wide and interdisciplinary overview of the current state of the art in the development of biomimetic materials for tissue regeneration on the basis of relevant and high-impact clinical needs. It specifically emphasizes the regeneration of bone, cartilage, and osteochondral tissues as well as soft tissues such as nerves, heart,

Musculoskeletal Tissue Regeneration

Musculoskeletal Tissue Regeneration
Author: William S. Pietrzak
Publisher: Humana Press
Total Pages: 0
Release: 2014-11-25
Genre: Medical
ISBN: 9781627038911
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The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.