Bayesian Markov Random Fields Analysis For Protein Function Prediction Based On Protein Protein Interaction Data
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Author | : Nordayana A. Rahim |
Publisher | : |
Total Pages | : |
Release | : 2010 |
Genre | : |
ISBN | : |
Download Bayesian Markov Random Fields Analysis for Protein Function Prediction Based on Protein Protein Interaction Data Book in PDF, Epub and Kindle
Author | : Yiannis A. I. Kourmpetis |
Publisher | : |
Total Pages | : 113 |
Release | : 2011 |
Genre | : |
ISBN | : 9789085859598 |
Download Bayesian Markov Random Field Analysis for Integrated Network-based Protein Function Prediction Book in PDF, Epub and Kindle
Author | : Wyatt Travis Clark |
Publisher | : Springer Science & Business Media |
Total Pages | : 50 |
Release | : 2014-01-09 |
Genre | : Computers |
ISBN | : 331904138X |
Download Information-Theoretic Evaluation for Computational Biomedical Ontologies Book in PDF, Epub and Kindle
The development of effective methods for the prediction of ontological annotations is an important goal in computational biology, yet evaluating their performance is difficult due to problems caused by the structure of biomedical ontologies and incomplete annotations of genes. This work proposes an information-theoretic framework to evaluate the performance of computational protein function prediction. A Bayesian network is used, structured according to the underlying ontology, to model the prior probability of a protein's function. The concepts of misinformation and remaining uncertainty are then defined, that can be seen as analogs of precision and recall. Finally, semantic distance is proposed as a single statistic for ranking classification models. The approach is evaluated by analyzing three protein function predictors of gene ontology terms. The work addresses several weaknesses of current metrics, and provides valuable insights into the performance of protein function prediction tools.
Author | : Weibo Cai |
Publisher | : BoD – Books on Demand |
Total Pages | : 488 |
Release | : 2012-03-30 |
Genre | : Science |
ISBN | : 9535103970 |
Download Protein-Protein Interactions Book in PDF, Epub and Kindle
Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.
Author | : Vineet Bafna |
Publisher | : Springer |
Total Pages | : 595 |
Release | : 2011-03-24 |
Genre | : Computers |
ISBN | : 3642200362 |
Download Research in Computational Molecular Biology Book in PDF, Epub and Kindle
This book constitutes the refereed proceedings of the 15th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2011, held in Vancouver, Canada, in March 2011. The 43 revised full papers were carefully reviewed and selected from 153 submissions. The papers cover a wide range of topics including molecular sequence analysis; recognition of genes and regulatory elements; molecular evolution; gene expression; biological networks; sequencing and genotyping technologies; genomics; population, statistical genetics; systems biology; imaging; computational proteomics; molecular structural biology.
Author | : Yanwen Wu |
Publisher | : Springer |
Total Pages | : 549 |
Release | : 2011-08-30 |
Genre | : Computers |
ISBN | : 3642240917 |
Download Computing and Intelligent Systems Book in PDF, Epub and Kindle
This six-volume-set (CCIS 231, 232, 233, 234, 235, 236) constitutes the refereed proceedings of the International Conference on Computing, Information and Control, ICCIC 2011, held in Wuhan, China, in September 2011. The papers are organized in two volumes on Innovative Computing and Information (CCIS 231 and 232), two volumes on Computing and Intelligent Systems (CCIS 233 and 234), and in two volumes on Information and Management Engineering (CCIS 235 and 236).
Author | : Alioune Ngom |
Publisher | : Springer |
Total Pages | : 307 |
Release | : 2013-07-04 |
Genre | : Computers |
ISBN | : 3642391591 |
Download Pattern Recognition in Bioinformatics Book in PDF, Epub and Kindle
This book constitutes the refereed proceedings of the 8th IAPR International Conference on Pattern Recognition in Bioinformatics, PRIB 2013, held in Nice, France, in June 2013. The 25 revised full papers presented were carefully reviewed and selected from 43 submissions. The papers are organized in topical sections on bio-molecular networks and pathway analysis; learning, classification, and clustering; data mining and knowledge discovery; protein: structure, function, and interaction; motifs, sites, and sequence analysis.
Author | : De-Shuang Huang |
Publisher | : Springer |
Total Pages | : 532 |
Release | : 2014-07-03 |
Genre | : Computers |
ISBN | : 3319093304 |
Download Intelligent Computing in Bioinformatics Book in PDF, Epub and Kindle
This book – in conjunction with the volumes LNCS 8588 and LNAI 8589 – constitutes the refereed proceedings of the 10th International Conference on Intelligent Computing, ICIC 2014, held in Taiyuan, China, in August 2014. The 58 papers of this volume were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections such as machine learning; neural networks; image processing; computational systems biology and medical informatics; biomedical informatics theory and methods; advances on bio-inspired computing; protein and gene bioinformatics: analysis, algorithms, applications.
Author | : Zhiguo Wang |
Publisher | : Springer Nature |
Total Pages | : 870 |
Release | : 2022-08-01 |
Genre | : Medical |
ISBN | : 3031049985 |
Download Polypharmacology Book in PDF, Epub and Kindle
There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.
Author | : Jingyu Hou |
Publisher | : Academic Press |
Total Pages | : 126 |
Release | : 2017-01-13 |
Genre | : Mathematics |
ISBN | : 0128099445 |
Download New Approaches of Protein Function Prediction from Protein Interaction Networks Book in PDF, Epub and Kindle
New Approaches of Protein Function Prediction from Protein Interaction Networks contains the critical aspects of PPI network based protein function prediction, including semantically assessing the reliability of PPI data, measuring the functional similarity between proteins, dynamically selecting prediction domains, predicting functions, and establishing corresponding prediction frameworks. Functional annotation of proteins is vital to biological and clinical research and other applications due to the important roles proteins play in various biological processes. Although the functions of some proteins have been annotated via biological experiments, there are still many proteins whose functions are yet to be annotated due to the limitations of existing methods and the high cost of experiments. To overcome experimental limitations, this book helps users understand the computational approaches that have been rapidly developed for protein function prediction. Provides innovative approaches and new developments targeting key issues in protein function prediction Presents heuristic ideas for further research in this challenging area