Basic Biology and Clinical Aspects of Inflammation

Basic Biology and Clinical Aspects of Inflammation
Author: Robert F. Diegelmann
Publisher: Bentham Science Publishers
Total Pages: 494
Release: 2016-03-07
Genre: Medical
ISBN: 1681082276

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Basic Biology and Clinical Aspects of Inflammation provides information about the critical cells and biochemical mediators involved in the complex process of inflammation. Readers are introduced to the basic scientific background on the subject, after which the book progresses towards translational research in clinical settings. Topics covered in this volume include, the modulation of inflammation during normal and chronic wound healing, altered metabolism during inflammation processes, the effect of ageing on inflammatory processes, as well as details about the underlying molecular processes behind specific clinical pathologies that are driven by excessive inflammation in the body (allergic reactions, type 2 diabetes, cardiac and vascular disease, arthritis, periodontal disease, inflammatory bowel disease and neuroinflammation). The volume also provides the latest information on pharmacotherapy for inflammation and interesting contributions towards the mathematical modeling and network analysis of inflammation. Basic Biology and Clinical Aspects of Inflammation features contributions from by a distinguished group of international researchers and clinicians highly recognized for their specific expertise in the field of inflammation. The information presented in this reference is useful to academics, medical professionals, health care regulators and pharmaceutical scientists.

Basic Biology and Clinical Aspects of Inflammation

Basic Biology and Clinical Aspects of Inflammation
Author: Bentham Science Publishers
Publisher:
Total Pages: 494
Release: 2016-03-07
Genre: Biology
ISBN: 9781681082288

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"Basic Biology and Clinical Aspects of Inflammation provides information about the critical cells and biochemical mediators involved in the complex process of inflammation. Readers are introduced to the basic scientific background on the subject, after whi"

Fundamentals of Inflammation

Fundamentals of Inflammation
Author: Charles N. Serhan
Publisher: Cambridge University Press
Total Pages: 489
Release: 2010-04-26
Genre: Science
ISBN: 1139936670

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The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Cancer and Inflammation Mechanisms

Cancer and Inflammation Mechanisms
Author: Yusuke Hiraku
Publisher: John Wiley & Sons
Total Pages: 467
Release: 2014-03-19
Genre: Science
ISBN: 1118826558

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A new perspective on the link between inflammation and cancer Inflammation is the human body’s normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory response is triggered repeatedly and sustained for long periods of time? Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects discusses the mechanisms by which chronic inflammation can lead to cancer, the various causative agents, and possible prevention methods. A compilation of the latest information coming out of the various fields of cancer research, this book provides a detailed look at inflammation-related carcinogenesis from the perspective of researchers at the forefront of the field. It takes an interdisciplinary approach to the topic, and provides comprehensive information about the major factors at work in inflammation, cancer, and the intersection of the two conditions. Topics include: A general overview of inflammation-related cancer The biochemistry of inflammation and its effects on DNA Molecular biology and the role of microRNA in carcinogenesis Specific causative agents including oncogenic viruses, asbestos, and nanomaterial Anti-inflammatories, nutraceuticals, and other preventative measures A deeper understanding of the mechanisms behind inflammation-related carcinogenesis can lead to better patient outcomes by improving diagnostics and prevention, as well as altering the approach to treatment. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects provides the knowledge base researchers need to push the field forward.

Inflammation: Basic, Clinical and Applied Aspects

Inflammation: Basic, Clinical and Applied Aspects
Author: Hazel Saunders
Publisher:
Total Pages: 294
Release: 2019-06-17
Genre:
ISBN: 9781632426864

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Inflammation is a complex biological response of the tissues of a body to harmful stimuli such as irritants, damaged cells and pathogens. It is a protective response involving the blood vessels, immune cells and molecular mediators. It acts to eliminate the cause of cell injury, clean out the necrotic cells and tissues harmed and initiate tissue repair. Less inflammation can lead to diseases such as periodontitis, rheumatoid arthritis, hay fever, atherosclerosis, etc. Inflammation can have a number of outcomes such as fibrous scarring, abscess formation and chronic inflammation. When the inflammatory response is no longer desirable, it should be terminated. Any failure of the body to do so results in cellular destruction and chronic inflammation. The objective of this book is to give a general view of the varied clinical aspects of inflammation. Different approaches, evaluations, methodologies and advanced studies on inflammation have been included in this book. Those in search of knowledge in this domain will be greatly assisted by this book.

Complex Systems and Computational Biology Approaches to Acute Inflammation

Complex Systems and Computational Biology Approaches to Acute Inflammation
Author: Yoram Vodovotz
Publisher: Springer Science & Business Media
Total Pages: 288
Release: 2013-08-15
Genre: Science
ISBN: 1461480086

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The difficulty in achieving effective translation of basic mechanistic biomedical knowledge into effective therapeutics, is the greatest challenge in biomedical research. Nowhere is this more apparent than in the reductionist approaches to understanding and manipulating the acute inflammatory response in the settings of sepsis, trauma/hemorrhage, wound healing, and related processes. This book discusses complex systems and computational biology methods and approaches that have advanced sufficiently to allow for knowledge generation, knowledge integration, and clinical translation in the settings of complex diseases related to the inflammatory response. Well-regulated, self-resolving inflammation is necessary for the appropriate communication and resolution of infection and trauma, and for maintenance of proper physiology and homeostasis. In contrast, self-sustaining inflammation drives the pathobiology of the aforementioned diseases. It is now increasingly recognized that controlling and reprogramming inflammation in order to reap the benefits of this evolutionarily-conserved process is preferred to simply abolishing indiscriminately.

Cells, Tissues, and Disease

Cells, Tissues, and Disease
Author: Guido Majno
Publisher: Oxford University Press
Total Pages: 1037
Release: 2004-08-26
Genre: Medical
ISBN: 0199748926

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This book lays out the principles of general pathology for biomedical researchers, grad students, medical students, and physicians, with elegance and deep insight. Disease processes are explained in the light of malfunctions at the cellular level, offering a rich understanding of the clinical correlates of all aspects of fundamental cellular physiology and basic biomedicine. The book has been fully revised and updated to present a current but deep understanding of disease states at the cell and tissue levels - cellular pathology, inflammation, immunopathology vascular disturbance, and tumor biology.

Chemokine Biology - Basic Research and Clinical Application

Chemokine Biology - Basic Research and Clinical Application
Author: Kuldeep Neote
Publisher: Springer Science & Business Media
Total Pages: 171
Release: 2007-08-08
Genre: Medical
ISBN: 3764374373

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Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.

Measuring Immunity

Measuring Immunity
Author: Michael T. Lotze
Publisher: Academic Press
Total Pages: 722
Release: 2005-01
Genre: Medical
ISBN: 9780124559004

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Integrates the current information available on biomarkers and surrogate assays into a single handbook. It highlights the principles behind various applications, gives a brief summary on how they are conducted and provides detailed and critical analyses of murine models of immunity, clinical trials, and tests to predict utility and benefit.

Chronic Inflammation

Chronic Inflammation
Author: Wen-Chang Chang
Publisher: Nova Science Publishers
Total Pages: 0
Release: 2013
Genre: Inflammation
ISBN: 9781628080940

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The primary focus of this book is to provide readers with a comprehensive overview of the recent advances in inflammation, especially in molecular biological and clinical aspects. Chapters contained in this book are written by invited authors from all over the world, who are well-known experts in their respective fields. In the book, chapters discussed include the molecular basis of inflammatory mechanisms, the functional roles of inflammation in diseases and new treatments of anti-inflammation. This book will be useful to all who wish to understand the scientific basis of inflammatory disease.