Assay Development and Evaluation
| Author | : Jan S. Krouwer |
| Publisher | : Amer. Assoc. for Clinical Chemistry |
| Total Pages | : 124 |
| Release | : 2002 |
| Genre | : Mathematics |
| ISBN | : 9781890883812 |
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Assay Development And Evaluation
Download Assay Development And Evaluation full books in PDF, epub, and Kindle. Read online free Assay Development And Evaluation ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Assay Development
| Author | : Ge Wu |
| Publisher | : John Wiley & Sons |
| Total Pages | : 452 |
| Release | : 2010-06-25 |
| Genre | : Science |
| ISBN | : 0470583118 |
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Essential principles and practice of assay development The first comprehensive, integrated treatment of the subject, Assay Development: Fundamentals and Practices covers the essentials and techniques involved in carrying out an assay project in either a biotechnology/drug discovery setting or a platform setting. Rather than attempting comprehensive coverage of all assay development technologies, the book introduces the most widely used assay development technologies and illustrates the art of assay development through a few commonly encountered biological targets in assay development (e.g., proteases, kinases, ion channels, and G protein-coupled receptors). Just enough biological background for these biological targets is provided so that the reader can follow the logics of assay development. Chapters discuss: The basics of assay development, including foundational concepts and applications Commonly used instrumental methods for both biochemical assays and cell-based assays Assay strategies for protein binding and enzymatic activity Cell-based assays High-throughput screening An in-depth study of the now popular Caliper's off-chip kinase assay provides an instructive, real-world example of the assay development process.
Drug Discovery and Evaluation: Pharmacological Assays
| Author | : Hans Vogel |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 2118 |
| Release | : 2007-10-30 |
| Genre | : Medical |
| ISBN | : 3540714200 |
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The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
Drug Discovery and Evaluation
| Author | : H. Gerhard Vogel |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 896 |
| Release | : 2006 |
| Genre | : Medical |
| ISBN | : 3540256385 |
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This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.
Handbook of Assay Development in Drug Discovery
| Author | : Lisa K. Minor |
| Publisher | : CRC Press |
| Total Pages | : 490 |
| Release | : 2006-01-20 |
| Genre | : Medical |
| ISBN | : 1420015702 |
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The Handbook of Assay Development in Drug Discovery describes all the tools currently available for performing various assay techniques. Featuring troubleshooting advice for common problems from experienced assay developers, the vendor community, and scientists in the pharmaceutical industry, the book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system, and troubleshooting tools. Designed as a guide to running an assay from start to finish, this is an ideal bench top companion for scientists involved in drug discovery screening, lead profiling, therapeutic target evaluation, and assay development and implementation.
Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
| Author | : H. Gerhard Vogel |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2013-02-27 |
| Genre | : Medical |
| ISBN | : 9783642252396 |
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-A landmark in the continuously changing world of drugs -Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process -Of use for government institutions and committees working on official guidelines for drug evaluation worldwide
Development and Evaluation of an Assay for Inhibitors of Complement Activation
| Author | : Xiaoyan Zhu |
| Publisher | : |
| Total Pages | : 206 |
| Release | : 1996 |
| Genre | : |
| ISBN | : |
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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 489: In Vivo Mammalian Alkaline Comet Assay
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 27 |
| Release | : 2016-07-29 |
| Genre | : |
| ISBN | : 9264264884 |
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The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
An Evidence Framework for Genetic Testing
| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 149 |
| Release | : 2017-04-21 |
| Genre | : Medical |
| ISBN | : 0309453291 |
Download An Evidence Framework for Genetic Testing Book in PDF, Epub and Kindle
Advances in genetics and genomics are transforming medical practice, resulting in a dramatic growth of genetic testing in the health care system. The rapid development of new technologies, however, has also brought challenges, including the need for rigorous evaluation of the validity and utility of genetic tests, questions regarding the best ways to incorporate them into medical practice, and how to weigh their cost against potential short- and long-term benefits. As the availability of genetic tests increases so do concerns about the achievement of meaningful improvements in clinical outcomes, costs of testing, and the potential for accentuating medical care inequality. Given the rapid pace in the development of genetic tests and new testing technologies, An Evidence Framework for Genetic Testing seeks to advance the development of an adequate evidence base for genetic tests to improve patient care and treatment. Additionally, this report recommends a framework for decision-making regarding the use of genetic tests in clinical care.
Chemical Genomics
| Author | : Haian Fu |
| Publisher | : Cambridge University Press |
| Total Pages | : 359 |
| Release | : 2012-02-13 |
| Genre | : Science |
| ISBN | : 1107377587 |
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Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry.
