In this issue of Interventional Cardiology Clinics, guest editor Dr. Vikas Aggarwal brings his considerable expertise to the topic of Pulmonary Embolism Interventions. Top experts in the field respond to the recent rise in interest to manage and invasively treat patients with acute and chronic pulmonary embolism (PE), covering key topics such as hemodynamic profiling of PE; catheter-directed thrombolysis or catheter-based thrombectomy in acute PE; mechanical circulatory support and critical care management of high-risk acute PE; open surgical treatment for acute and chronic PE; exercise testing, medical management, and rehabilitation in chronic PE; and more. Contains 15 relevant, practice-oriented topics including pulmonary artery denervation in management of pulmonary hypertension; Pulmonary Vascular Disease Center of Excellence: putting it all together; unmet needs and future direction for PE interventions; multimodality imaging for acute and chronic thrombo-embolic pulmonary disease; evolving role and clinical evidence in the global practice of balloon pulmonary angioplasty; outpatient follow up of PE; and more. Provides in-depth clinical reviews on pulmonary embolism interventions, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.