Antibiotic Pharmacokinetic Pharmacodynamic Considerations In The Critically Ill
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Author | : Andrew A. Udy |
Publisher | : Springer |
Total Pages | : 275 |
Release | : 2017-09-18 |
Genre | : Medical |
ISBN | : 9811053367 |
Download Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill Book in PDF, Epub and Kindle
This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.
Author | : Alexander A. Vinks |
Publisher | : Springer Science & Business Media |
Total Pages | : 467 |
Release | : 2013-11-23 |
Genre | : Medical |
ISBN | : 0387756132 |
Download Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics Book in PDF, Epub and Kindle
Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
Author | : John C. Rotschafer |
Publisher | : Humana |
Total Pages | : 0 |
Release | : 2016-03-30 |
Genre | : Medical |
ISBN | : 9781493933211 |
Download Antibiotic Pharmacodynamics Book in PDF, Epub and Kindle
This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.
Author | : John A. Kellum |
Publisher | : Oxford University Press |
Total Pages | : 329 |
Release | : 2016 |
Genre | : Medical |
ISBN | : 019022553X |
Download Continuous Renal Replacement Therapy Book in PDF, Epub and Kindle
Continuous Renal Replacement Therapy provides concise, evidence-based, bedside guidance for the management of critically ill patients with acute renal failure, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice.
Author | : Samuel A. Tisherman |
Publisher | : Oxford University Press, USA |
Total Pages | : 350 |
Release | : 2013-07-11 |
Genre | : Medical |
ISBN | : 0199777705 |
Download Trauma Intensive Care Book in PDF, Epub and Kindle
An ideal resource for intensivists caring for trauma victims in the ICU, Trauma Intensive Care provides point-of-care guidelines for establishing the priorities of care, minimizing complications, and returning patients to the best possible functional outcome.
Author | : Bret Berner |
Publisher | : John Wiley & Sons |
Total Pages | : 466 |
Release | : 2021-08-31 |
Genre | : Medical |
ISBN | : 1119772737 |
Download Drug Delivery Approaches Book in PDF, Epub and Kindle
Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Author | : Tamar F. Barlam |
Publisher | : Cambridge University Press |
Total Pages | : 343 |
Release | : 2018-04-26 |
Genre | : Medical |
ISBN | : 1107166179 |
Download Practical Implementation of an Antibiotic Stewardship Program Book in PDF, Epub and Kindle
This practical reference guide from experts in the field details why and how to establish successful antibiotic stewardship programs.
Author | : Hendrick K.F. van Saene |
Publisher | : Springer Science & Business Media |
Total Pages | : 509 |
Release | : 2009-11-02 |
Genre | : Medical |
ISBN | : 8847016010 |
Download Infection Control in the Intensive Care Unit Book in PDF, Epub and Kindle
Intensive care is a rapidly changing area of medicine, and after four years from the 2nd edition the volume editors and authors have deemed necessary to update it. In the recent years, in fact, five new randomised controlled trials and five new meta-analyses demonstrate that selective decontamination of the digestive tract [SDD] is an antimicrobial prophylaxis to prevent severe infections of not only lower airways but also of blood. Additionally, SDD has been shown to reduce inflammation including multiple organ failure and mortality. An intriguing observation is the evidence that SDD using parenteral and enteral antimicrobials reduces rather than increases antimicrobial resistance. Moreover, a new chapter on microcirculation had been added. The volume will be an invaluable tool for all those requiring in depth knowledge in the ever expanding field of infection control.
Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : 1995 |
Genre | : Antibiotics |
ISBN | : |
Download Antimicrobial Therapy I Book in PDF, Epub and Kindle
Author | : Jeffrey Hoag |
Publisher | : BoD – Books on Demand |
Total Pages | : 188 |
Release | : 2016-11-30 |
Genre | : Medical |
ISBN | : 9535127810 |
Download Oncology Critical Care Book in PDF, Epub and Kindle
According to the American Cancer Society, more than 1.6 million people will be diagnosed with cancer during this year. Outcomes have steadily risen over the last several decades with the advent of newer therapies. As outcomes have improved, more and more cancer patients are developing critical illness. In the not-too-distant past, patients with active malignancy were thought not appropriate for critical care services as decreased longevity related to the cancer suggested poor prognosis for intensive care utilization. More recently, evidence supports rapid activation of critical care services leading to improved outcomes in cancer patients. Moreover, just as sub-subspecialty critical care experience in trauma and neurosciences has proved beneficial, the emerging field of oncology critical care warrants specific attention.