Annual Reports in Combinatorial Chemistry and Molecular Diversity

Annual Reports in Combinatorial Chemistry and Molecular Diversity
Author: W.H. Moos
Publisher: Springer Science & Business Media
Total Pages: 376
Release: 1997-04-30
Genre: Medical
ISBN: 9789072199232

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Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. This first volume covers: (i) combinatorial chemistry, (ii) combinatorial biology and evolution, and (iii) informatics and related topics. Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs. parallel individual compound synthesis, solution vs. solid-phase synthesis, analytical tools, and automation. Section II highlights selection strategies and library-based evolution, phage display, peptide and nucleic acid libraries. Section III covers databases and library design, high through-put screening, coding strategies vs. deconvolutions, intellectual property issues, deals and collaborations, and successes to date.

Annual Reports in Combinatorial Chemistry and Molecular Diversity

Annual Reports in Combinatorial Chemistry and Molecular Diversity
Author: M.R. Pavia
Publisher: Springer
Total Pages: 188
Release: 1999-06-30
Genre: Science
ISBN: 9780792357223

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Combinatorial chemistry and molecular diversity approaches to scientific and novel product R & D have exploded in the 1990s. For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. The second volume in this series includes contributions on methods, solid phases, purification, analysis, carbohydrates, patent strategies and tactics, diversity profiling and combinatorial series design, and finishes with a survey of chemical libraries yielding biologically active agents and a compendium of solid phase chemistry publications. Each contribution is prepared by a recognized expert resulting in a high quality account of the recent advances in the field.

Molecular Diversity and Combinatorial Chemistry

Molecular Diversity and Combinatorial Chemistry
Author: Irwin M. Chaiken
Publisher:
Total Pages: 346
Release: 1996
Genre: Medical
ISBN:

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Reports progress on chemical, enzymatic, phage, and cell-derived libra ries. Discusses synergy between structure-based design and combinatori al libraries. Presents applications of combinatorial libraries to drug discovery and new synthetic catalysis. Reports library screening appr oaches, including the use of NMR. Presents recent advances in solid-ph ase organic synthesis, liquid-phase organic synthesis, and high-throug hput combinatorial organic synthesis. Discusses automation of organic synthesis as well as new methodologies for monitoring solid-phase orga nic synthesis.

Molecular Diversity and Combinatorial Chemistry

Molecular Diversity and Combinatorial Chemistry
Author: Michael C. Pirrung
Publisher: Elsevier
Total Pages: 196
Release: 2004-10-17
Genre: Language Arts & Disciplines
ISBN: 9780080445328

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Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.

Combinatorial Chemistry and Technologies

Combinatorial Chemistry and Technologies
Author: Stanislav Miertus
Publisher: CRC Press
Total Pages: 616
Release: 2005-04-12
Genre: Medical
ISBN: 0824758374

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Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.

Analytical Techniques in Combinatorial Chemistry

Analytical Techniques in Combinatorial Chemistry
Author: Michael E. Swartz
Publisher: CRC Press
Total Pages: 314
Release: 2000-02-18
Genre: Science
ISBN: 0824746694

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This volume aims to provide the necessary tools for developing methods and analyzing results in the drug discovery process, and supports documenting and managing the process in a combinatorial setting. It describes the chromatographic and spectroscopic techniques used to generate chemical and molecular diversity in new compounds, focusing on applications of information management systems, instrumentation, and robotics.

Combinatorial Chemistry and Technology

Combinatorial Chemistry and Technology
Author: Stanislav Miertus
Publisher: CRC Press
Total Pages: 456
Release: 1999-07-01
Genre: Science
ISBN: 9781420000566

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"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."

Progress in Medicinal Chemistry

Progress in Medicinal Chemistry
Author:
Publisher: Elsevier
Total Pages: 319
Release: 1999-05-14
Genre: Medical
ISBN: 0080862845

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Progress in Medicinal Chemistry

Combinatorial Chemistry

Combinatorial Chemistry
Author: Willi Bannwarth
Publisher: John Wiley & Sons
Total Pages: 450
Release: 2009-08-14
Genre: Science
ISBN: 352761415X

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As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among research methods, allowing scientists to efficiently test the feasibility of a multitude of new compounds. The pursuit of new drugs is but one challenging field in which these combinatorial methods are particularly advantageous, helping researchers meet the modern-day demands of a highly competitive environment. This book emphasises that modern combinatorial synthesis is possible not only in the solid phase, but also in solutions. Moreover, it discusses computer-assisted methods as well as the apparatus and instrumentation required for the combinatorial method. Successful and experienced researchers in the leading pharmaceutical companies and most renowned research institutes offer a solid insight and perspective into this diverse field. A 'must' for every scientist in the area of pharmaceutical research