Animal Models of Ophthalmic Diseases

Animal Models of Ophthalmic Diseases
Author: Chi-Chao Chan
Publisher: Springer
Total Pages: 165
Release: 2015-12-01
Genre: Medical
ISBN: 3319194348

Download Animal Models of Ophthalmic Diseases Book in PDF, Epub and Kindle

This book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ disease, and intraocular tumors. In conjunction, these models reflect the diversity and utility of tools used to study human disease. World expert clinicians discuss each model based on their clinical experience and the text is supported by numerous photos and diagrams. In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents and medical students.

Animal Models in Eye Research

Animal Models in Eye Research
Author:
Publisher: Academic Press
Total Pages: 230
Release: 2011-04-28
Genre: Science
ISBN: 0080921035

Download Animal Models in Eye Research Book in PDF, Epub and Kindle

The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms use different ways to achieve these tasks. In this sense, eye function becomes a very important evolutionary aspect as well. This book presents the different animal models that are commonly used for eye research and their uniqueness in evaluating different aspects of eye development, evolution, physiology and disease. Presents information on the major animal models used in eye research including invertebrates and vertebrates Provides researchers with information needed to choose between model organisms Includes an introductory chapter on the different types of eyes, stressing possible common molecular machinery

Animal Models for Retinal Diseases

Animal Models for Retinal Diseases
Author: Iok-Hou Pang
Publisher: Humana
Total Pages: 229
Release: 2016-08-23
Genre: Medical
ISBN: 9781493957507

Download Animal Models for Retinal Diseases Book in PDF, Epub and Kindle

Affecting over a hundred million individuals worldwide, retinal diseases are among the leading causes of irreversible visual impairment and blindness, and appropriate study models, especially animal models, are essential to furthering our understanding of the etiology, pathology, and progression of these endemic diseases. In Animal Models for Retinal Diseases, recognized experts in the field highlight valuable techniques as well as animal models for the prominent retinal diseases in order to aid in the evaluation, development, and improvement of therapeutic strategies. Beginning with an overview of the morphology of the retina, visual behavior, and genetics and genomics approaches for retinal research, the book continues by covering animal models for the research of specific human retinal diseases, e.g., retinal degeneration, age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, glaucoma, retinal ischemia, and retinal inflammation. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used approaches in the field. Vital and easy to use, Animal Models for Retinal Diseases serves to support the important future research of ocular investigators, ophthalmologists, and neuroscientists currently delving into this fascinating field of study.

Animal Models of Ocular Diseases

Animal Models of Ocular Diseases
Author: Khalid F. Tabbara
Publisher: Charles C. Thomas Publisher
Total Pages: 308
Release: 1984
Genre: Medical
ISBN:

Download Animal Models of Ocular Diseases Book in PDF, Epub and Kindle

Myopia: Animal Models To Clinical Trials

Myopia: Animal Models To Clinical Trials
Author: Donald Tiang Hwee Tan
Publisher: World Scientific
Total Pages: 420
Release: 2010-04-23
Genre: Medical
ISBN: 9814470392

Download Myopia: Animal Models To Clinical Trials Book in PDF, Epub and Kindle

Myopia is the most common optical disorder in the world, and is on the rise in many countries, particularly in East Asia. The impact of myopia is evident as the driving force in the development of refractive surgery and of the spectacle and contact lens industries. While myopia is often seen as a childhood disease that involves complex genetic-environmental factors, it is also a major cause of adult blindness. In Singapore (where myopia has reached one of the highest rates in the world) as well as in Taiwan, Japan and Hong Kong, affected patients have greater severity of myopia, leading to additional secondary complications such as glaucoma.This book provides a comprehensive coverage of all aspects of myopia. It is aimed at ophthalmologists, optometrists, opticians, scientists and pharmaceutical companies. The topics are uniquely treated in that they cover research at the laboratory bench as well as clinical applications and population-based approaches in epidemiology.

Animal Models in Vision Research

Animal Models in Vision Research
Author: Bahram Bodaghi
Publisher: S. Karger AG (Switzerland)
Total Pages: 0
Release: 2008
Genre: Anatomy
ISBN: 9783805585842

Download Animal Models in Vision Research Book in PDF, Epub and Kindle

A multidisciplinary and translational approach Doubtless, inflammatory processes are involved in the pathogenesis of various ocular diseases. Autoimmunity, inflammation and infection may initiate a large spectrum of pathologic processes or contribute to their progression. In light of the recent introduction of novel therapeutic interventions in ophthalmic disorders, it is necessary to revisit experimental models of ocular inflammation and discuss the relevance of each of them to human diseases. This publication presents the contributions made during the workshop on animal models of ocular inflammation held by the International Ocular Inflammation Society in Paris in 2007. The presence of expert immunologists, molecular biologists, geneticists and physicians, dealing with specific aspects of diseases, was a major step towards a multidisciplinary and translational approach. This special issue provides validated animal models addressing pathogenesis which are the starting point of developing novel therapies based on immune mechanisms learned from these models. Ophthalmologists, immunologists, pathologists and pharmacologists interested in drug delivery for intraocular disorders will find it valuable reading.

OCT and Imaging in Central Nervous System Diseases

OCT and Imaging in Central Nervous System Diseases
Author:
Publisher:
Total Pages: 560
Release: 2020
Genre: Central nervous system
ISBN: 9783030262709

Download OCT and Imaging in Central Nervous System Diseases Book in PDF, Epub and Kindle

The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson's disease, Alzheimer's disease, intracranial hypertension, Friedreich's ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinal diseases and monitoring of surgical and medical treatment. OCT allows to study vision from of the retina to the optic tracts. Retinal axons in the retinal nerve fiber layer (RNFL) are non-myelinated until they penetrate the lamina cribrosa. Hence, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the "window to the brain".

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author: Caroline J. Zeiss
Publisher: Elsevier Inc. Chapters
Total Pages: 47
Release: 2013-05-29
Genre: Medical
ISBN: 0128071958

Download Animal Models for the Study of Human Disease Book in PDF, Epub and Kindle

Age-related macular degeneration (AMD) is a degenerative condition that begins in Bruch’s membrane and progresses to involve the retinal pigment epithelium and ultimately, overlying photoreceptors. The only required etiologic factor is age, and AMD is regarded as the leading cause of blindness in individuals over 65 years. AMD results from variable contributions of age, environment, and genetic predisposition. Many loci are linked to AMD—in the vast majority of cases, the disease is associated with polymorphisms within these genes, rather than mutations that ablate gene function. The etiologic complexity of AMD is reflected by the paucity of animal models that entirely replicate the human disease. In this review, we compare the salient anatomy of the primate and rodent retina, particularly in the light of AMD pathology. Next, prevailing hypotheses explaining how AMD may develop are discussed. These include the role of complement activation and macrophage chemotaxis in AMD, molecular mechanisms of choroidal neovascularization, and the roles of oxidative damage and lipid metabolism. An overview of spontaneous and induced non-human primate models is given, and relevant mouse models are described in the context of each pathogenetic mechanism.

Retinal Degenerative Diseases

Retinal Degenerative Diseases
Author: Matthew M. LaVail
Publisher: Springer Science & Business Media
Total Pages: 867
Release: 2011-12-21
Genre: Medical
ISBN: 1461406315

Download Retinal Degenerative Diseases Book in PDF, Epub and Kindle

This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

Retinal Degenerations

Retinal Degenerations
Author: Joyce Tombran-Tink
Publisher: Springer Science & Business Media
Total Pages: 465
Release: 2007-11-06
Genre: Medical
ISBN: 159745186X

Download Retinal Degenerations Book in PDF, Epub and Kindle

This book presents new and noteworthy research into retinal diseases. It focuses on what we currently know about the environment, genetics and mechanisms that lead to retinal degenerations, new diagnostics, and innovative therapeutic modalities to preserve vision. Written by renowned scientific investigators, this innovative collection of treatment strategies and technological discoveries allows for the realistic translation of research into practice.